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Leukaemia is cancer that affects the white blood cells (lymphocytes). It affects the blood and bone marrow, where blood cells are made. Leukaemia may be acute, appearing fast and growing quickly, or chronic, appearing gradually and growing slowly. Most childhood leukaemias are acute. Children with leukaemia usually need treatment for 2 to 3 years, as well as ongoing regular check-ups to monitor and treat any late effects. There are several types of leukaemia seen in children, including:
Types of leukaemia differ in the type of cell they originate from, as well as in the way they are treated and their chance of successful treatment. Watch this video from Cancer Australia about what it can be like to have cancer as a child:
What are the symptoms of childhood leukaemia?For acute types of childhood leukaemia — ALL and AML — symptoms include:
The symptoms of leukaemia are similar to that of some other common conditions. If you notice any of these symptoms, it doesn't mean your child has leukaemia, but it's a good idea to see your doctor. What causes leukaemia?The exact causes of leukaemia in children are not known, but it is likely that several factors are involved. Factors that may put some children at higher risk of genetic damage that can lead to leukaemia include:
How is childhood leukaemia diagnosed?Many symptoms of childhood leukaemia are general and can be caused by a range of illnesses. To make a definite diagnosis of leukaemia, a number of tests need to be done. Your doctor will most likely give your child a physical examination and take a sample of their blood so it can be examined under a microscope. If the blood test shows large numbers of abnormal white blood cells, and low numbers of healthy blood cells, more tests will be done to confirm the diagnosis. Tests to find leukaemiaThere are several tests that can be done to confirm a diagnosis of leukaemia, and to work out which type it is:
Staging and further testsThe 'stage' of leukaemia describes how far the cancer has spread. Doctors conduct staging with tests including a chest x-ray, CT scan or lumbar puncture. They may also look for chromosomal changes in your child’s blood. How is childhood leukaemia treated?The main treatment given to children with leukaemia is chemotherapy (a combination of medicines), usually as tablets or injections. Radiotherapy may also be used to kill cancer cells in the brain, and in some cases, a stem cell or bone marrow transplant may also be necessary. Other treatments include:
Treatments for leukaemia in children, as with adults, can cause a range of short-term side effects, such as nausea and loss of hair. Longer-term effects, called 'late effects', can also develop any time after treatment, so ongoing check-ups are needed. Living with childhood leukaemiaChildren with leukaemia can need treatment for up to 3 years. During this time, it's important they have the opportunity to live as normal a life as possible. Whenever feeling well enough, they should be encouraged to do their usual activities, like having playtime, and going to school or day care. Caring for a child with leukaemia can be very challenging and stressful. Many support services exist to help families, including Cancer Councils in each state and territory (call 13 11 20), and the Leukaemia Foundation. Resources and supportFor more information and support, try these resources: Learn more here about the development and quality assurance of healthdirect content. Last reviewed: March 2021 These trusted information partners have more on this topic.
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ABOUT CAUSES DIAGNOSIS TREATMENT NEXT STEPS
Leukemia is cancer of the blood. It’s the most common form of cancer in childhood. The cancer cells grow in bone marrow and go into the blood. The bone marrow is the soft, spongy center of some bones. It makes blood cells. When a child has leukemia, the bone marrow makes abnormal blood cells that don’t mature. The abnormal cells are usually white blood cells (leukocytes). The bone marrow also makes fewer healthy cells. The abnormal cells reproduce very quickly. They don’t work the same as healthy cells. The types of blood cells include:
There are different types of leukemia in children. Most leukemias in children are acute, which means they tend to grow quickly. Some of the types of leukemia that occur in children include:
What causes leukemia in children?The exact cause of leukemia in children is not known. There are certain conditions passed on from parents to children (inherited) that increase the risk for childhood leukemia. But, most childhood leukemia is not inherited. Researchers have found changes (mutations) in genes of the bone marrow cells. These changes may occur early in a child's life or even before birth. But they may occur by chance (sporadic).
The risk factors for childhood leukemia include:
The symptoms depend on many factors. The cancer may be in the bone marrow, blood, and other tissue and organs. These may include the lymph nodes, liver, spleen, thymus, brain, spinal cord, gums, and skin. Symptoms can occur a bit differently in each child. They can include:
The symptoms of leukemia can be like other health conditions. Make sure your child sees a healthcare provider for a diagnosis.
Your child's healthcare provider will ask many questions about your child's symptoms. He or she will examine your child. Your child's healthcare provider may recommend blood tests and other tests. A complete blood count (CBC) provides the number of red blood cells, different types of white blood cells, and platelets. If the results are abnormal, your child's healthcare provider may recommend that your child see a pediatric cancer specialist (pediatric oncologist). The oncologist may want your child to have additional tests including:
When leukemia is diagnosed, the doctor will find out the exact type of leukemia it is. Leukemia is not assigned a stage number like most other cancers. Instead, it's classified into groups, sub-types, or both. ALL (acute lymphocytic leukemia) is the most common leukemia in children. It's separated into 2 groups based on the type of lymphocyte the leukemia started in. That would be B cells or T cells. About 8 out of 10 cases of ALL in children are B-cell ALLs. These can be further classified into sub-types. The other 2 out of 10 cases are T-cell ALLs. AML (acute myelogenous leukemia) is the other kind of leukemia that's common in children. Doctors use 2 different systems to classify AML. The French-American-British (FAB) system divides AML into 8 sub-types based on how the cells look under the microscope. The World Health Organization (WHO) classification system is newer. It groups AML into many groups based on things like the details of the gene changes in the cancer cells as well as the FAB sub-types. Classifying leukemia is very complex. But it's an important part of making treatment plans and predicting treatment outcomes. Be sure to ask your child's healthcare provider to explain the stage of your child's leukemia to you in a way you can understand.
Your child may first need to be treated for low blood counts, bleeding, or infections. Your child may receive:
Treatment will depend on the type of leukemia and other factors. Leukemia can be treated with any of the below:
A child may have complications from the tumor or from treatment. They may also be short-term or long-term. Treatment may have many side effects. Some side effects may be minor. Some may be serious and even life-threatening. Your child may take medicines to help prevent or lessen side effects. You’ll be given instructions about what you can do at home. Possible complications of leukemia can include:
Possible long-term complications from the leukemia or the treatment can include:
What can I do to prevent leukemia in my child?Most childhood cancers, including leukemia, can’t be prevented. The risk from X-rays and CT scans is very small. But healthcare providers advise against them in pregnant women and children unless absolutely needed.
A child with leukemia needs ongoing care. Your child will be seen by oncologists and other healthcare providers to treat any late effects of treatment and to watch for signs or symptoms of the cancer returning. Your child will be checked with imaging tests and other tests. And your child may see other healthcare providers for problems from the cancer or from treatment. You can help your child manage his or her treatment in many ways. For example:
Call the healthcare provider if your child has:
Key points about leukemia in children
Tips to help you get the most from a visit to your child’s healthcare provider:
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