This preview shows page 1 - 3 out of 9 pages. Page 2
HEMAGGLUTININS (ANTIBODY) ** ROIHL-19267-03 Serial comparative study of Von SEE IMMUNOLOGY, ANTIBODIES, HEMAGGLUTININS anticoagulants (rats) Willebrand's disease (human) ** ROIHL-14890-08 Platelet prostaglandins (human, rabbits) ** ROI HL-19270-03 Effects of erythropoiesis on platelets and HEMAGGLUTININS (PLANT) ** ROIHL-14992-08 Mechanism of thrombin action (human) hemostasis (rats) SEE PLANTS PROTEINS, LECTINS ** ROIHL-15226-07 Interaction of blood cells with fibrinogen ** ROIHL-19278-04 Biophysics/biochemistry of 1 degree and fibrin (human, animals) platelet aggregation (human) HEMATOCRIT ** ROIHL-15230-06 Molecular basis of V Willebrand's disease ** ROI HL-19282-04 Regulation of the activation of human SEE BLOOD (HEMATOLOGIC) TESTS, BLOOD CELL COUNT* and hemophilia (human, cattle) factor x and 11 HEMATOLOGIC AGENTS ** ROIHL-15335-07 Blood platelet interactions with ** ROI HL-19323-04 Studies of platelet microtubule protein aggregants (animals) ** ROI HL-19333-04 SEE BLOOD AND RE DRUGS (GENERAL) Hematopoietic chimerism (mice, monkey) ** ROIHL-15474-07 Structure and function of the ROI HL-19646-04 An immunologic study of hemoglobin HEMATOLOGIC TESTS antihemophilic factor (human, cattle) variation in man SEE BLOOD (HEMATOLOGIC) TESTS* ** ROIHL-15491-07 Blood coagulation--Platelet-plasma ** ROI HL-19767-02 Pathochemistry of fibrinogen (humans) protein interaction (human) ** ROI HL-19933-03 Membrane and red cell dysfunction in HEMATOLOGY ** ROIHL-15615-07 Structure-function studies of human hemolytic anemia (human) SEE BLOOD AND RE SYSTEM, HEMATOLOGY factor VIII/VWF ** ROI HL-19996-03 Role of membrane proteins in platelet HEMATOLOGY STUDY SECTION ** ROIHL-15616-05 Platelet membrane proteins in function (human, rabbits) ** ROI HL-20014-03 ** ROIHL-01601-31 aggregation (human) Radioimmunoassay of hyper and Blood coagulation and hemorrhagic ** ROIHL-15619-06 disease (horseshoe crabs) Regulation of prothrombin synthesis in hypocoagulable states (rabbits) ** ROI HL-20074-03 ** ROIHL-01648-32 cultured cells (rats) Structure and function of amidinated Blood coagulation and hemophilia (dogs, ** ROIHL-15647-07 swine) Hematopoietic studies of cyclic human hemoglobin ** ROI HL-20092-03 ** ROIHL-01661-28 hematopoiesis (dogs) Structural and biological properties of Hemostatic mechanisms (human) ** ROIHL-0221224 ** ROIHL-15685-06 Coagulation of blood (human) Hemopoietic regulators produced in cell fibrinogen (human, rabbits) ** ROTHL-02254-24 ** ROI HL-20114-03 Collagen-platelet interaction and human disease (human, animals) ** ROIHL-15690-08 Hydrolytic enzymes of blood in health aorta collagen (human) ** ROIHL-02262-23 ** ROI HL-20140-03 Mechanisms regulating plasma proteins and disease (human, animals) Glycoproteins of platelet membrane and and solutes (human, dogs) ** ROIHL-15728-07 The carbohydrate of the blood-clotting platelet function (human) ** ROIHL-02799-22 ** ROI HL-20141-03 Abnormal hemoglobins (human) glycoproteins (mammals) Biochemical approaches to management ** ROIHL-03357-22 Extrarenal erythropoietin and its ** ROIHL-15793-06 Molecular aspects of erythrocyte of iron overload (human, sheep, dogs) membrane resealing (human) ** ROI HL-20142-03 production (rats, rabbits, mice) Functional studies of abnormal human ** ROIHL-03424-22 Formation and properties of prothrombin ** ROIHL-15817-07 Plasminogen activators from tissues hemoglobins derivatives (human, animals) (human, pig, cattle) ** ROIHL-20218-03 Fibrinogen catabolism and intravascular ** ROIHL-04366-21 Plasminogen-Activation and structure** ROIHL-15887-06 Enzymes of blood coagulation and coagulation (human) function relations (mammals, birds) fibrinolysis (human) ** ROI HL-20303-04 Cholesterol distribution in erythrocyte * ROIHL-04612-21 Feedback between red cell production ** ROIHL-16150-06 Primary structure of prothrombin (cattle, membrane (human) and oxygen transport (rabbits, rats) human) ** ROI HL-20317-03 Procoagulant lipoproteins-- Biochemistry ** ROIHL-05168-20 Inhomogencity of hemoglobin types ** ROIHL-16238-06 Protein structure in coagulation and and bioactivity (goats, rabbits) (human) fibrinolysis (human) ** RO1 HL-20577-04 The mechanism of action of vitamin K ** ROIHL-05351-19 Blood group antigens and antibodies ** ROIHL-16346-10 Enzyme assay for blood clotting (human) ** ROI HL-20750-02 Studies in sickle cell disea se (human) (human, rabbits, sheep) ** ROIHL-16355-06 Reactions of thrombin and collagen with ** ROI HL-20826-03 Meg akaryocyte proliferation and its ** ROIHL-05791-19 Structure and function in hemoglobins platelets (human) control (mice) (human) ** ROIHL-16361-04 Fibrin complexes in intermediary ** ROI HL-20846-03 Purification of bovine plasminogen ** ROIHL-06242-19 Kinetic studies of blood (human) coagulation (human) proactivator ** ROIHL-06950-18 Red cell metabolism (human, ROTHL16375-05 Investigation of hemoglobin S properties ** ROI HL-20920-02 Control of hemoglobin synthesis (baboon) vertebrates) (human) ** ROI HL-20925-02 The acetylation of fetal hemoglobin ** ROIHL-07379-14 Structure and function of fibrinogen ** ROIHL-16633-05 Chemistry and biology of factor IX (human) (human) activator (human, mice, rats) ** ROI HL-20971-11 Membrane glycoproteins of platelets and ** ROZHL-07652-14 Destruction of red blood cells in ** ROIHL-16634-14 Function of platelets and coagulation leukocytes (human) hemolytic anemias (human, guinea pigs) tactors (human) ** ROI HL-21113-02 Control mechanisms in coagulation ** ROIHL-09163-14 Control mechanisms in hemostasis ** ROIHL-16654-07 Regulation in developing erythroid cells (cattle) (human) (human) ** R23 HL-21128-03 ATP utilization in platelet contractile ** ROTHL-09902-14 Comparative study of coagulation and ** ROIHL-16675-06 Human urinary erythropoietin collection mechanisms (human, rabbits) vascular disease (animals) ** ROIHL-16720-03 Platelet aggregation (human) ** R23 HL-21129-03 The antisickling effects of imidoesters ** ROTHL-10036-14 Biology of red cell antigen-antibody ** ROIHL-16757-05 'Autoimmune' thrombocytopenia (monkey) ** RO1 HL-21139-03 Molecular biology of factor XIII (human) reaction (human) ** ROIHL-16872-05 Antihemophilic factor (human) ** R23 HL-21208-03 Structure-function relationships of human ** ROIHL-10567-13 Erythropoietin--Immunoassay and ** ROIHL-16931-05 Red cell storage and transtusion factor VIII characterization (human, dogs) (human, animals) ** ROI HL-21379-02 Structure of factor VIII-Von Willebrand ** ROIHL-10880-14 Purification of human erythropoietin for ** ROIHL-16955-06 Heparin, blood coagulation and lipid protein (human) research use metabolism (human) ROI HL-21431-03 Factor II antigen and coagulant activity ** ROIHL-11154-13 Blood group antigens and antibodies ** ROIHL-17513-05 Role of PF-4 in detecting and promoting (human, animals) (human) thrombosis (human, primates) ** ROI HL-21469-02 Active transport and effect of CA00 in ** ROIHL-11172-13 Physiology and biochemistry of ** ROIHL-17729-05 Stimulus-response coupling in platelets sickle cell (human) fibrinolytic enzymes (human, animals) (human) ** ROI HL-21487-02 Molecular characterization of ** ROIHL-11775-12 Platelet mechanisms in disease (human, ** ROIHL-17881-16 Biosynthesis and degradation of blood Glanzmann's thrombasthenia (human) primates) group substances (human) ** R23 HL-21490-03 Studies of enzymes in human platelet ** ROIHL-11880-11 Physiology and pathology of blood ** ROIHL-17964-05 The alternate pathway for fibrinolysis membranes platelets (human, dogs) (human) ** ROI HL-21543-03 Structure-function relation of blood ** ROIHL-12820-10 In vitro regulation of prothrombin ** ROIHL-18012-05 Cellular defects in nocturnal clotting proteins (rabbits) activation hemoglobinuria (human) ** ROI HL-21544-03 ** ROIHL-12944-10 Proteins of coagulation and Hageman Enzymatic and biochemical studies on ROTHL-18030-05 The role of contractile proteins in factor pathways (human, goats) blood cells (human) ** ROI HL-21560-01 ** RO1HL-12972-10 platelets (human, rabbits) Siderosis--Chelation therapy and Glutathione deficiency in red cells ** ROIHL-18068-03 Chemistry and activity of homologous mechanisms (rats) (sheep, dogs) ** R23 HL-21730-02 •* ROIHL-12994.10 heparin fractions (rodents) Wagll--A new vWD deficient antigen The Rh complex of red cells (human) ** ROIHL-18082-03 ** ROIHL-13155-09 Erythrocyte phosphates and vertebrate (human) ** ROI HL-21988-02 defibrination Biochemistry of human pla telet ** ROIHL-18284-05 ** ROIHL-13160-09 chemotaxis Human thrombin (also cattle) Aging erythrocytes--Bio-recognition and elimination (monkeys) ** ROI HL-22035-02 Molecular modification of heparin by ROTHL-13198-22 Blood coagulation--Physico-chemical ** ROIHL-18333-06 Throm bogenesis and hemostatic balance chemical means (sheep) properties (human, cattle) ** ROIHL-13336-10 (rabbits, human) ** ROI HL-22119-02 Biochemistry of platelet function in Biochemistry and physiology of human ** ROIHL-18435-03 platelets Properties of thrombin and Ac-globulin thrombosis and cell growth (rabbits) ** ROIHL-13423-09 ** RO1 HL-22227-02 A new source of hyaluronid ase and ** ROIHL-18551-03 and plasmin (human) Spectrin, actin, lipid and red cell anticoagulants (leeches) ** ROI HL-22289-02 •* ROIHL-13591-07 membrane structure Endothelial cell mediated fibrinolysis Structure of fibers of sickle cell ** ROIHL-18586-03 hemoglobin (human) Role of platelet lipids in hemostasis and (rabbits) ** ROIHL-13629-10 ** ROI HL-22355-02 thrombosis (human) Hemorrhagic diseases (human) Purification, structure and function of ** ROIHL-13881-08 The American Red Cross National ** ROIHL.186 18-05 Purification and function of human HMW factor VIII (human) kininogen ** ROI HL-22410-01 Fractionation Center ADP-induced NAO influx linked to platelet ** ROIHL-14020-07 Characterization of contractile proteins in ** ROIHL-18650-03 Platelet collagen interaction (human) aggregation (human) platelets (human) ROIHL-18672-03 Dynamics of clot structure formation ** ROI HL-22451-01 Regulation of megakaryopo iesis (human, ** ROIHL-14131-19 Abnormal hemoglobin syndromes (human) mice) (human) ** ROIHL-18834-05 Metal-dependent complex formation in ** ROI HL-22471-02 Biochemistry of prothrombin quick ** ROTHL-14344-08 Platelet function and adenine nucleotide blood coagulation (human, cattle) (human) metabolism (human) ** ROIHL-18852-04 Biochemical studies on the blood ** ROI HL-22479-01 Iron chelators delivery in red cell ghosts ** ROIHL-14595-08 Primary disorders of platelet function coagulation process (human, cattle) (rats) (human, rats) ** ROIHL-18859-03 Biochemistry of human factor XI (human) ** ROI HL-22502-02 Role of phosphoinositides in human ** ROIHL-14637-06 Thrombopoietin--immunoassay and ROIHL-18935-03 Platelets, fibrinogen, soluble fibrin platelet secretion characterization (mice) interaction (human) ** ROI HL-22505-02 Molecular pathology of fibrinogen and ** ROTHL-14697-08 Role of platelet membranes in ** ROIHL-18937-04 Cyclic nucleotides and calcium in factor XIII (human, animals) hemostasis (human) platelets (human) •* R23 HL-22621-02 Blood cell mediated pulmonary (human) ** ROIHL-14739-07 The role of leukocytes in thrombotic ** ROIHL-19131-05 Hypercoagulability and the heparin • ROI HL-22642-01 Fibrinogen proteolysis in hemostasis and disease (human, dogs) antithrombin mechanism (human) thrombosis (human) (contd) *Excludes routine methodology OR covers only general projects which preclude indexing at the specific level. M Grant has subprojects describing specific research aspects. Page 3Page 4
HEMAGGLUTININS (ANTIBODY) ** ROIHL-19267-03 Serial comparative study of Von SEE IMMUNOLOGY, ANTIBODIES, HEMAGGLUTININS anticoagulants (rats) Willebrand's disease (human) ** ROIHL-14890-08 Platelet prostaglandins (human, rabbits) ** ROI HL-19270-03 Effects of erythropoiesis on platelets and HEMAGGLUTININS (PLANT) ** ROIHL-14992-08 Mechanism of thrombin action (human) hemostasis (rats) SEE PLANTS PROTEINS, LECTINS ** ROIHL-15226-07 Interaction of blood cells with fibrinogen ** ROIHL-19278-04 Biophysics/biochemistry of 1 degree and fibrin (human, animals) platelet aggregation (human) HEMATOCRIT ** ROIHL-15230-06 Molecular basis of V Willebrand's disease ** ROI HL-19282-04 Regulation of the activation of human SEE BLOOD (HEMATOLOGIC) TESTS, BLOOD CELL COUNT* and hemophilia (human, cattle) factor x and 11 HEMATOLOGIC AGENTS ** ROIHL-15335-07 Blood platelet interactions with ** ROI HL-19323-04 Studies of platelet microtubule protein aggregants (animals) ** ROI HL-19333-04 SEE BLOOD AND RE DRUGS (GENERAL) Hematopoietic chimerism (mice, monkey) ** ROIHL-15474-07 Structure and function of the ROI HL-19646-04 An immunologic study of hemoglobin HEMATOLOGIC TESTS antihemophilic factor (human, cattle) variation in man SEE BLOOD (HEMATOLOGIC) TESTS* ** ROIHL-15491-07 Blood coagulation--Platelet-plasma ** ROI HL-19767-02 Pathochemistry of fibrinogen (humans) protein interaction (human) ** ROI HL-19933-03 Membrane and red cell dysfunction in HEMATOLOGY ** ROIHL-15615-07 Structure-function studies of human hemolytic anemia (human) SEE BLOOD AND RE SYSTEM, HEMATOLOGY factor VIII/VWF ** ROI HL-19996-03 Role of membrane proteins in platelet HEMATOLOGY STUDY SECTION ** ROIHL-15616-05 Platelet membrane proteins in function (human, rabbits) ** ROI HL-20014-03 ** ROIHL-01601-31 aggregation (human) Radioimmunoassay of hyper and Blood coagulation and hemorrhagic ** ROIHL-15619-06 disease (horseshoe crabs) Regulation of prothrombin synthesis in hypocoagulable states (rabbits) ** ROI HL-20074-03 ** ROIHL-01648-32 cultured cells (rats) Structure and function of amidinated Blood coagulation and hemophilia (dogs, ** ROIHL-15647-07 swine) Hematopoietic studies of cyclic human hemoglobin ** ROI HL-20092-03 ** ROIHL-01661-28 hematopoiesis (dogs) Structural and biological properties of Hemostatic mechanisms (human) ** ROIHL-0221224 ** ROIHL-15685-06 Coagulation of blood (human) Hemopoietic regulators produced in cell fibrinogen (human, rabbits) ** ROTHL-02254-24 ** ROI HL-20114-03 Collagen-platelet interaction and human disease (human, animals) ** ROIHL-15690-08 Hydrolytic enzymes of blood in health aorta collagen (human) ** ROIHL-02262-23 ** ROI HL-20140-03 Mechanisms regulating plasma proteins and disease (human, animals) Glycoproteins of platelet membrane and and solutes (human, dogs) ** ROIHL-15728-07 The carbohydrate of the blood-clotting platelet function (human) ** ROIHL-02799-22 ** ROI HL-20141-03 Abnormal hemoglobins (human) glycoproteins (mammals) Biochemical approaches to management ** ROIHL-03357-22 Extrarenal erythropoietin and its ** ROIHL-15793-06 Molecular aspects of erythrocyte of iron overload (human, sheep, dogs) membrane resealing (human) ** ROI HL-20142-03 production (rats, rabbits, mice) Functional studies of abnormal human ** ROIHL-03424-22 Formation and properties of prothrombin ** ROIHL-15817-07 Plasminogen activators from tissues hemoglobins derivatives (human, animals) (human, pig, cattle) ** ROIHL-20218-03 Fibrinogen catabolism and intravascular ** ROIHL-04366-21 Plasminogen-Activation and structure** ROIHL-15887-06 Enzymes of blood coagulation and coagulation (human) function relations (mammals, birds) fibrinolysis (human) ** ROI HL-20303-04 Cholesterol distribution in erythrocyte * ROIHL-04612-21 Feedback between red cell production ** ROIHL-16150-06 Primary structure of prothrombin (cattle, membrane (human) and oxygen transport (rabbits, rats) human) ** ROI HL-20317-03 Procoagulant lipoproteins-- Biochemistry ** ROIHL-05168-20 Inhomogencity of hemoglobin types ** ROIHL-16238-06 Protein structure in coagulation and and bioactivity (goats, rabbits) (human) fibrinolysis (human) ** RO1 HL-20577-04 The mechanism of action of vitamin K ** ROIHL-05351-19 Blood group antigens and antibodies ** ROIHL-16346-10 Enzyme assay for blood clotting (human) ** ROI HL-20750-02 Studies in sickle cell disea se (human) (human, rabbits, sheep) ** ROIHL-16355-06 Reactions of thrombin and collagen with ** ROI HL-20826-03 Meg akaryocyte proliferation and its ** ROIHL-05791-19 Structure and function in hemoglobins platelets (human) control (mice) (human) ** ROIHL-16361-04 Fibrin complexes in intermediary ** ROI HL-20846-03 Purification of bovine plasminogen ** ROIHL-06242-19 Kinetic studies of blood (human) coagulation (human) proactivator ** ROIHL-06950-18 Red cell metabolism (human, ROTHL16375-05 Investigation of hemoglobin S properties ** ROI HL-20920-02 Control of hemoglobin synthesis (baboon) vertebrates) (human) ** ROI HL-20925-02 The acetylation of fetal hemoglobin ** ROIHL-07379-14 Structure and function of fibrinogen ** ROIHL-16633-05 Chemistry and biology of factor IX (human) (human) activator (human, mice, rats) ** ROI HL-20971-11 Membrane glycoproteins of platelets and ** ROZHL-07652-14 Destruction of red blood cells in ** ROIHL-16634-14 Function of platelets and coagulation leukocytes (human) hemolytic anemias (human, guinea pigs) tactors (human) ** ROI HL-21113-02 Control mechanisms in coagulation ** ROIHL-09163-14 Control mechanisms in hemostasis ** ROIHL-16654-07 Regulation in developing erythroid cells (cattle) (human) (human) ** R23 HL-21128-03 ATP utilization in platelet contractile ** ROTHL-09902-14 Comparative study of coagulation and ** ROIHL-16675-06 Human urinary erythropoietin collection mechanisms (human, rabbits) vascular disease (animals) ** ROIHL-16720-03 Platelet aggregation (human) ** R23 HL-21129-03 The antisickling effects of imidoesters ** ROTHL-10036-14 Biology of red cell antigen-antibody ** ROIHL-16757-05 'Autoimmune' thrombocytopenia (monkey) ** RO1 HL-21139-03 Molecular biology of factor XIII (human) reaction (human) ** ROIHL-16872-05 Antihemophilic factor (human) ** R23 HL-21208-03 Structure-function relationships of human ** ROIHL-10567-13 Erythropoietin--Immunoassay and ** ROIHL-16931-05 Red cell storage and transtusion factor VIII characterization (human, dogs) (human, animals) ** ROI HL-21379-02 Structure of factor VIII-Von Willebrand ** ROIHL-10880-14 Purification of human erythropoietin for ** ROIHL-16955-06 Heparin, blood coagulation and lipid protein (human) research use metabolism (human) ROI HL-21431-03 Factor II antigen and coagulant activity ** ROIHL-11154-13 Blood group antigens and antibodies ** ROIHL-17513-05 Role of PF-4 in detecting and promoting (human, animals) (human) thrombosis (human, primates) ** ROI HL-21469-02 Active transport and effect of CA00 in ** ROIHL-11172-13 Physiology and biochemistry of ** ROIHL-17729-05 Stimulus-response coupling in platelets sickle cell (human) fibrinolytic enzymes (human, animals) (human) ** ROI HL-21487-02 Molecular characterization of ** ROIHL-11775-12 Platelet mechanisms in disease (human, ** ROIHL-17881-16 Biosynthesis and degradation of blood Glanzmann's thrombasthenia (human) primates) group substances (human) ** R23 HL-21490-03 Studies of enzymes in human platelet ** ROIHL-11880-11 Physiology and pathology of blood ** ROIHL-17964-05 The alternate pathway for fibrinolysis membranes platelets (human, dogs) (human) ** ROI HL-21543-03 Structure-function relation of blood ** ROIHL-12820-10 In vitro regulation of prothrombin ** ROIHL-18012-05 Cellular defects in nocturnal clotting proteins (rabbits) activation hemoglobinuria (human) ** ROI HL-21544-03 ** ROIHL-12944-10 Proteins of coagulation and Hageman Enzymatic and biochemical studies on ROTHL-18030-05 The role of contractile proteins in factor pathways (human, goats) blood cells (human) ** ROI HL-21560-01 ** RO1HL-12972-10 platelets (human, rabbits) Siderosis--Chelation therapy and Glutathione deficiency in red cells ** ROIHL-18068-03 Chemistry and activity of homologous mechanisms (rats) (sheep, dogs) ** R23 HL-21730-02 •* ROIHL-12994.10 heparin fractions (rodents) Wagll--A new vWD deficient antigen The Rh complex of red cells (human) ** ROIHL-18082-03 ** ROIHL-13155-09 Erythrocyte phosphates and vertebrate (human) ** ROI HL-21988-02 defibrination Biochemistry of human pla telet ** ROIHL-18284-05 ** ROIHL-13160-09 chemotaxis Human thrombin (also cattle) Aging erythrocytes--Bio-recognition and elimination (monkeys) ** ROI HL-22035-02 Molecular modification of heparin by ROTHL-13198-22 Blood coagulation--Physico-chemical ** ROIHL-18333-06 Throm bogenesis and hemostatic balance chemical means (sheep) properties (human, cattle) ** ROIHL-13336-10 (rabbits, human) ** ROI HL-22119-02 Biochemistry of platelet function in Biochemistry and physiology of human ** ROIHL-18435-03 platelets Properties of thrombin and Ac-globulin thrombosis and cell growth (rabbits) ** ROIHL-13423-09 ** RO1 HL-22227-02 A new source of hyaluronid ase and ** ROIHL-18551-03 and plasmin (human) Spectrin, actin, lipid and red cell anticoagulants (leeches) ** ROI HL-22289-02 •* ROIHL-13591-07 membrane structure Endothelial cell mediated fibrinolysis Structure of fibers of sickle cell ** ROIHL-18586-03 hemoglobin (human) Role of platelet lipids in hemostasis and (rabbits) ** ROIHL-13629-10 ** ROI HL-22355-02 thrombosis (human) Hemorrhagic diseases (human) Purification, structure and function of ** ROIHL-13881-08 The American Red Cross National ** ROIHL.186 18-05 Purification and function of human HMW factor VIII (human) kininogen ** ROI HL-22410-01 Fractionation Center ADP-induced NAO influx linked to platelet ** ROIHL-14020-07 Characterization of contractile proteins in ** ROIHL-18650-03 Platelet collagen interaction (human) aggregation (human) platelets (human) ROIHL-18672-03 Dynamics of clot structure formation ** ROI HL-22451-01 Regulation of megakaryopo iesis (human, ** ROIHL-14131-19 Abnormal hemoglobin syndromes (human) mice) (human) ** ROIHL-18834-05 Metal-dependent complex formation in ** ROI HL-22471-02 Biochemistry of prothrombin quick ** ROTHL-14344-08 Platelet function and adenine nucleotide blood coagulation (human, cattle) (human) metabolism (human) ** ROIHL-18852-04 Biochemical studies on the blood ** ROI HL-22479-01 Iron chelators delivery in red cell ghosts ** ROIHL-14595-08 Primary disorders of platelet function coagulation process (human, cattle) (rats) (human, rats) ** ROIHL-18859-03 Biochemistry of human factor XI (human) ** ROI HL-22502-02 Role of phosphoinositides in human ** ROIHL-14637-06 Thrombopoietin--immunoassay and ROIHL-18935-03 Platelets, fibrinogen, soluble fibrin platelet secretion characterization (mice) interaction (human) ** ROI HL-22505-02 Molecular pathology of fibrinogen and ** ROTHL-14697-08 Role of platelet membranes in ** ROIHL-18937-04 Cyclic nucleotides and calcium in factor XIII (human, animals) hemostasis (human) platelets (human) •* R23 HL-22621-02 Blood cell mediated pulmonary (human) ** ROIHL-14739-07 The role of leukocytes in thrombotic ** ROIHL-19131-05 Hypercoagulability and the heparin • ROI HL-22642-01 Fibrinogen proteolysis in hemostasis and disease (human, dogs) antithrombin mechanism (human) thrombosis (human) (contd) *Excludes routine methodology OR covers only general projects which preclude indexing at the specific level. M Grant has subprojects describing specific research aspects. Page 5Page 6
HEMAGGLUTININS (ANTIBODY) ** ROIHL-19267-03 Serial comparative study of Von SEE IMMUNOLOGY, ANTIBODIES, HEMAGGLUTININS anticoagulants (rats) Willebrand's disease (human) ** ROIHL-14890-08 Platelet prostaglandins (human, rabbits) ** ROI HL-19270-03 Effects of erythropoiesis on platelets and HEMAGGLUTININS (PLANT) ** ROIHL-14992-08 Mechanism of thrombin action (human) hemostasis (rats) SEE PLANTS PROTEINS, LECTINS ** ROIHL-15226-07 Interaction of blood cells with fibrinogen ** ROIHL-19278-04 Biophysics/biochemistry of 1 degree and fibrin (human, animals) platelet aggregation (human) HEMATOCRIT ** ROIHL-15230-06 Molecular basis of V Willebrand's disease ** ROI HL-19282-04 Regulation of the activation of human SEE BLOOD (HEMATOLOGIC) TESTS, BLOOD CELL COUNT* and hemophilia (human, cattle) factor x and 11 HEMATOLOGIC AGENTS ** ROIHL-15335-07 Blood platelet interactions with ** ROI HL-19323-04 Studies of platelet microtubule protein aggregants (animals) ** ROI HL-19333-04 SEE BLOOD AND RE DRUGS (GENERAL) Hematopoietic chimerism (mice, monkey) ** ROIHL-15474-07 Structure and function of the ROI HL-19646-04 An immunologic study of hemoglobin HEMATOLOGIC TESTS antihemophilic factor (human, cattle) variation in man SEE BLOOD (HEMATOLOGIC) TESTS* ** ROIHL-15491-07 Blood coagulation--Platelet-plasma ** ROI HL-19767-02 Pathochemistry of fibrinogen (humans) protein interaction (human) ** ROI HL-19933-03 Membrane and red cell dysfunction in HEMATOLOGY ** ROIHL-15615-07 Structure-function studies of human hemolytic anemia (human) SEE BLOOD AND RE SYSTEM, HEMATOLOGY factor VIII/VWF ** ROI HL-19996-03 Role of membrane proteins in platelet HEMATOLOGY STUDY SECTION ** ROIHL-15616-05 Platelet membrane proteins in function (human, rabbits) ** ROI HL-20014-03 ** ROIHL-01601-31 aggregation (human) Radioimmunoassay of hyper and Blood coagulation and hemorrhagic ** ROIHL-15619-06 disease (horseshoe crabs) Regulation of prothrombin synthesis in hypocoagulable states (rabbits) ** ROI HL-20074-03 ** ROIHL-01648-32 cultured cells (rats) Structure and function of amidinated Blood coagulation and hemophilia (dogs, ** ROIHL-15647-07 swine) Hematopoietic studies of cyclic human hemoglobin ** ROI HL-20092-03 ** ROIHL-01661-28 hematopoiesis (dogs) Structural and biological properties of Hemostatic mechanisms (human) ** ROIHL-0221224 ** ROIHL-15685-06 Coagulation of blood (human) Hemopoietic regulators produced in cell fibrinogen (human, rabbits) ** ROTHL-02254-24 ** ROI HL-20114-03 Collagen-platelet interaction and human disease (human, animals) ** ROIHL-15690-08 Hydrolytic enzymes of blood in health aorta collagen (human) ** ROIHL-02262-23 ** ROI HL-20140-03 Mechanisms regulating plasma proteins and disease (human, animals) Glycoproteins of platelet membrane and and solutes (human, dogs) ** ROIHL-15728-07 The carbohydrate of the blood-clotting platelet function (human) ** ROIHL-02799-22 ** ROI HL-20141-03 Abnormal hemoglobins (human) glycoproteins (mammals) Biochemical approaches to management ** ROIHL-03357-22 Extrarenal erythropoietin and its ** ROIHL-15793-06 Molecular aspects of erythrocyte of iron overload (human, sheep, dogs) membrane resealing (human) ** ROI HL-20142-03 production (rats, rabbits, mice) Functional studies of abnormal human ** ROIHL-03424-22 Formation and properties of prothrombin ** ROIHL-15817-07 Plasminogen activators from tissues hemoglobins derivatives (human, animals) (human, pig, cattle) ** ROIHL-20218-03 Fibrinogen catabolism and intravascular ** ROIHL-04366-21 Plasminogen-Activation and structure** ROIHL-15887-06 Enzymes of blood coagulation and coagulation (human) function relations (mammals, birds) fibrinolysis (human) ** ROI HL-20303-04 Cholesterol distribution in erythrocyte * ROIHL-04612-21 Feedback between red cell production ** ROIHL-16150-06 Primary structure of prothrombin (cattle, membrane (human) and oxygen transport (rabbits, rats) human) ** ROI HL-20317-03 Procoagulant lipoproteins-- Biochemistry ** ROIHL-05168-20 Inhomogencity of hemoglobin types ** ROIHL-16238-06 Protein structure in coagulation and and bioactivity (goats, rabbits) (human) fibrinolysis (human) ** RO1 HL-20577-04 The mechanism of action of vitamin K ** ROIHL-05351-19 Blood group antigens and antibodies ** ROIHL-16346-10 Enzyme assay for blood clotting (human) ** ROI HL-20750-02 Studies in sickle cell disea se (human) (human, rabbits, sheep) ** ROIHL-16355-06 Reactions of thrombin and collagen with ** ROI HL-20826-03 Meg akaryocyte proliferation and its ** ROIHL-05791-19 Structure and function in hemoglobins platelets (human) control (mice) (human) ** ROIHL-16361-04 Fibrin complexes in intermediary ** ROI HL-20846-03 Purification of bovine plasminogen ** ROIHL-06242-19 Kinetic studies of blood (human) coagulation (human) proactivator ** ROIHL-06950-18 Red cell metabolism (human, ROTHL16375-05 Investigation of hemoglobin S properties ** ROI HL-20920-02 Control of hemoglobin synthesis (baboon) vertebrates) (human) ** ROI HL-20925-02 The acetylation of fetal hemoglobin ** ROIHL-07379-14 Structure and function of fibrinogen ** ROIHL-16633-05 Chemistry and biology of factor IX (human) (human) activator (human, mice, rats) ** ROI HL-20971-11 Membrane glycoproteins of platelets and ** ROZHL-07652-14 Destruction of red blood cells in ** ROIHL-16634-14 Function of platelets and coagulation leukocytes (human) hemolytic anemias (human, guinea pigs) tactors (human) ** ROI HL-21113-02 Control mechanisms in coagulation ** ROIHL-09163-14 Control mechanisms in hemostasis ** ROIHL-16654-07 Regulation in developing erythroid cells (cattle) (human) (human) ** R23 HL-21128-03 ATP utilization in platelet contractile ** ROTHL-09902-14 Comparative study of coagulation and ** ROIHL-16675-06 Human urinary erythropoietin collection mechanisms (human, rabbits) vascular disease (animals) ** ROIHL-16720-03 Platelet aggregation (human) ** R23 HL-21129-03 The antisickling effects of imidoesters ** ROTHL-10036-14 Biology of red cell antigen-antibody ** ROIHL-16757-05 'Autoimmune' thrombocytopenia (monkey) ** RO1 HL-21139-03 Molecular biology of factor XIII (human) reaction (human) ** ROIHL-16872-05 Antihemophilic factor (human) ** R23 HL-21208-03 Structure-function relationships of human ** ROIHL-10567-13 Erythropoietin--Immunoassay and ** ROIHL-16931-05 Red cell storage and transtusion factor VIII characterization (human, dogs) (human, animals) ** ROI HL-21379-02 Structure of factor VIII-Von Willebrand ** ROIHL-10880-14 Purification of human erythropoietin for ** ROIHL-16955-06 Heparin, blood coagulation and lipid protein (human) research use metabolism (human) ROI HL-21431-03 Factor II antigen and coagulant activity ** ROIHL-11154-13 Blood group antigens and antibodies ** ROIHL-17513-05 Role of PF-4 in detecting and promoting (human, animals) (human) thrombosis (human, primates) ** ROI HL-21469-02 Active transport and effect of CA00 in ** ROIHL-11172-13 Physiology and biochemistry of ** ROIHL-17729-05 Stimulus-response coupling in platelets sickle cell (human) fibrinolytic enzymes (human, animals) (human) ** ROI HL-21487-02 Molecular characterization of ** ROIHL-11775-12 Platelet mechanisms in disease (human, ** ROIHL-17881-16 Biosynthesis and degradation of blood Glanzmann's thrombasthenia (human) primates) group substances (human) ** R23 HL-21490-03 Studies of enzymes in human platelet ** ROIHL-11880-11 Physiology and pathology of blood ** ROIHL-17964-05 The alternate pathway for fibrinolysis membranes platelets (human, dogs) (human) ** ROI HL-21543-03 Structure-function relation of blood ** ROIHL-12820-10 In vitro regulation of prothrombin ** ROIHL-18012-05 Cellular defects in nocturnal clotting proteins (rabbits) activation hemoglobinuria (human) ** ROI HL-21544-03 ** ROIHL-12944-10 Proteins of coagulation and Hageman Enzymatic and biochemical studies on ROTHL-18030-05 The role of contractile proteins in factor pathways (human, goats) blood cells (human) ** ROI HL-21560-01 ** RO1HL-12972-10 platelets (human, rabbits) Siderosis--Chelation therapy and Glutathione deficiency in red cells ** ROIHL-18068-03 Chemistry and activity of homologous mechanisms (rats) (sheep, dogs) ** R23 HL-21730-02 •* ROIHL-12994.10 heparin fractions (rodents) Wagll--A new vWD deficient antigen The Rh complex of red cells (human) ** ROIHL-18082-03 ** ROIHL-13155-09 Erythrocyte phosphates and vertebrate (human) ** ROI HL-21988-02 defibrination Biochemistry of human pla telet ** ROIHL-18284-05 ** ROIHL-13160-09 chemotaxis Human thrombin (also cattle) Aging erythrocytes--Bio-recognition and elimination (monkeys) ** ROI HL-22035-02 Molecular modification of heparin by ROTHL-13198-22 Blood coagulation--Physico-chemical ** ROIHL-18333-06 Throm bogenesis and hemostatic balance chemical means (sheep) properties (human, cattle) ** ROIHL-13336-10 (rabbits, human) ** ROI HL-22119-02 Biochemistry of platelet function in Biochemistry and physiology of human ** ROIHL-18435-03 platelets Properties of thrombin and Ac-globulin thrombosis and cell growth (rabbits) ** ROIHL-13423-09 ** RO1 HL-22227-02 A new source of hyaluronid ase and ** ROIHL-18551-03 and plasmin (human) Spectrin, actin, lipid and red cell anticoagulants (leeches) ** ROI HL-22289-02 •* ROIHL-13591-07 membrane structure Endothelial cell mediated fibrinolysis Structure of fibers of sickle cell ** ROIHL-18586-03 hemoglobin (human) Role of platelet lipids in hemostasis and (rabbits) ** ROIHL-13629-10 ** ROI HL-22355-02 thrombosis (human) Hemorrhagic diseases (human) Purification, structure and function of ** ROIHL-13881-08 The American Red Cross National ** ROIHL.186 18-05 Purification and function of human HMW factor VIII (human) kininogen ** ROI HL-22410-01 Fractionation Center ADP-induced NAO influx linked to platelet ** ROIHL-14020-07 Characterization of contractile proteins in ** ROIHL-18650-03 Platelet collagen interaction (human) aggregation (human) platelets (human) ROIHL-18672-03 Dynamics of clot structure formation ** ROI HL-22451-01 Regulation of megakaryopo iesis (human, ** ROIHL-14131-19 Abnormal hemoglobin syndromes (human) mice) (human) ** ROIHL-18834-05 Metal-dependent complex formation in ** ROI HL-22471-02 Biochemistry of prothrombin quick ** ROTHL-14344-08 Platelet function and adenine nucleotide blood coagulation (human, cattle) (human) metabolism (human) ** ROIHL-18852-04 Biochemical studies on the blood ** ROI HL-22479-01 Iron chelators delivery in red cell ghosts ** ROIHL-14595-08 Primary disorders of platelet function coagulation process (human, cattle) (rats) (human, rats) ** ROIHL-18859-03 Biochemistry of human factor XI (human) ** ROI HL-22502-02 Role of phosphoinositides in human ** ROIHL-14637-06 Thrombopoietin--immunoassay and ROIHL-18935-03 Platelets, fibrinogen, soluble fibrin platelet secretion characterization (mice) interaction (human) ** ROI HL-22505-02 Molecular pathology of fibrinogen and ** ROTHL-14697-08 Role of platelet membranes in ** ROIHL-18937-04 Cyclic nucleotides and calcium in factor XIII (human, animals) hemostasis (human) platelets (human) •* R23 HL-22621-02 Blood cell mediated pulmonary (human) ** ROIHL-14739-07 The role of leukocytes in thrombotic ** ROIHL-19131-05 Hypercoagulability and the heparin • ROI HL-22642-01 Fibrinogen proteolysis in hemostasis and disease (human, dogs) antithrombin mechanism (human) thrombosis (human) (contd) *Excludes routine methodology OR covers only general projects which preclude indexing at the specific level. M Grant has subprojects describing specific research aspects. Page 7Page 8
HEMAGGLUTININS (ANTIBODY) ** ROIHL-19267-03 Serial comparative study of Von SEE IMMUNOLOGY, ANTIBODIES, HEMAGGLUTININS anticoagulants (rats) Willebrand's disease (human) ** ROIHL-14890-08 Platelet prostaglandins (human, rabbits) ** ROI HL-19270-03 Effects of erythropoiesis on platelets and HEMAGGLUTININS (PLANT) ** ROIHL-14992-08 Mechanism of thrombin action (human) hemostasis (rats) SEE PLANTS PROTEINS, LECTINS ** ROIHL-15226-07 Interaction of blood cells with fibrinogen ** ROIHL-19278-04 Biophysics/biochemistry of 1 degree and fibrin (human, animals) platelet aggregation (human) HEMATOCRIT ** ROIHL-15230-06 Molecular basis of V Willebrand's disease ** ROI HL-19282-04 Regulation of the activation of human SEE BLOOD (HEMATOLOGIC) TESTS, BLOOD CELL COUNT* and hemophilia (human, cattle) factor x and 11 HEMATOLOGIC AGENTS ** ROIHL-15335-07 Blood platelet interactions with ** ROI HL-19323-04 Studies of platelet microtubule protein aggregants (animals) ** ROI HL-19333-04 SEE BLOOD AND RE DRUGS (GENERAL) Hematopoietic chimerism (mice, monkey) ** ROIHL-15474-07 Structure and function of the ROI HL-19646-04 An immunologic study of hemoglobin HEMATOLOGIC TESTS antihemophilic factor (human, cattle) variation in man SEE BLOOD (HEMATOLOGIC) TESTS* ** ROIHL-15491-07 Blood coagulation--Platelet-plasma ** ROI HL-19767-02 Pathochemistry of fibrinogen (humans) protein interaction (human) ** ROI HL-19933-03 Membrane and red cell dysfunction in HEMATOLOGY ** ROIHL-15615-07 Structure-function studies of human hemolytic anemia (human) SEE BLOOD AND RE SYSTEM, HEMATOLOGY factor VIII/VWF ** ROI HL-19996-03 Role of membrane proteins in platelet HEMATOLOGY STUDY SECTION ** ROIHL-15616-05 Platelet membrane proteins in function (human, rabbits) ** ROI HL-20014-03 ** ROIHL-01601-31 aggregation (human) Radioimmunoassay of hyper and Blood coagulation and hemorrhagic ** ROIHL-15619-06 disease (horseshoe crabs) Regulation of prothrombin synthesis in hypocoagulable states (rabbits) ** ROI HL-20074-03 ** ROIHL-01648-32 cultured cells (rats) Structure and function of amidinated Blood coagulation and hemophilia (dogs, ** ROIHL-15647-07 swine) Hematopoietic studies of cyclic human hemoglobin ** ROI HL-20092-03 ** ROIHL-01661-28 hematopoiesis (dogs) Structural and biological properties of Hemostatic mechanisms (human) ** ROIHL-0221224 ** ROIHL-15685-06 Coagulation of blood (human) Hemopoietic regulators produced in cell fibrinogen (human, rabbits) ** ROTHL-02254-24 ** ROI HL-20114-03 Collagen-platelet interaction and human disease (human, animals) ** ROIHL-15690-08 Hydrolytic enzymes of blood in health aorta collagen (human) ** ROIHL-02262-23 ** ROI HL-20140-03 Mechanisms regulating plasma proteins and disease (human, animals) Glycoproteins of platelet membrane and and solutes (human, dogs) ** ROIHL-15728-07 The carbohydrate of the blood-clotting platelet function (human) ** ROIHL-02799-22 ** ROI HL-20141-03 Abnormal hemoglobins (human) glycoproteins (mammals) Biochemical approaches to management ** ROIHL-03357-22 Extrarenal erythropoietin and its ** ROIHL-15793-06 Molecular aspects of erythrocyte of iron overload (human, sheep, dogs) membrane resealing (human) ** ROI HL-20142-03 production (rats, rabbits, mice) Functional studies of abnormal human ** ROIHL-03424-22 Formation and properties of prothrombin ** ROIHL-15817-07 Plasminogen activators from tissues hemoglobins derivatives (human, animals) (human, pig, cattle) ** ROIHL-20218-03 Fibrinogen catabolism and intravascular ** ROIHL-04366-21 Plasminogen-Activation and structure** ROIHL-15887-06 Enzymes of blood coagulation and coagulation (human) function relations (mammals, birds) fibrinolysis (human) ** ROI HL-20303-04 Cholesterol distribution in erythrocyte * ROIHL-04612-21 Feedback between red cell production ** ROIHL-16150-06 Primary structure of prothrombin (cattle, membrane (human) and oxygen transport (rabbits, rats) human) ** ROI HL-20317-03 Procoagulant lipoproteins-- Biochemistry ** ROIHL-05168-20 Inhomogencity of hemoglobin types ** ROIHL-16238-06 Protein structure in coagulation and and bioactivity (goats, rabbits) (human) fibrinolysis (human) ** RO1 HL-20577-04 The mechanism of action of vitamin K ** ROIHL-05351-19 Blood group antigens and antibodies ** ROIHL-16346-10 Enzyme assay for blood clotting (human) ** ROI HL-20750-02 Studies in sickle cell disea se (human) (human, rabbits, sheep) ** ROIHL-16355-06 Reactions of thrombin and collagen with ** ROI HL-20826-03 Meg akaryocyte proliferation and its ** ROIHL-05791-19 Structure and function in hemoglobins platelets (human) control (mice) (human) ** ROIHL-16361-04 Fibrin complexes in intermediary ** ROI HL-20846-03 Purification of bovine plasminogen ** ROIHL-06242-19 Kinetic studies of blood (human) coagulation (human) proactivator ** ROIHL-06950-18 Red cell metabolism (human, ROTHL16375-05 Investigation of hemoglobin S properties ** ROI HL-20920-02 Control of hemoglobin synthesis (baboon) vertebrates) (human) ** ROI HL-20925-02 The acetylation of fetal hemoglobin ** ROIHL-07379-14 Structure and function of fibrinogen ** ROIHL-16633-05 Chemistry and biology of factor IX (human) (human) activator (human, mice, rats) ** ROI HL-20971-11 Membrane glycoproteins of platelets and ** ROZHL-07652-14 Destruction of red blood cells in ** ROIHL-16634-14 Function of platelets and coagulation leukocytes (human) hemolytic anemias (human, guinea pigs) tactors (human) ** ROI HL-21113-02 Control mechanisms in coagulation ** ROIHL-09163-14 Control mechanisms in hemostasis ** ROIHL-16654-07 Regulation in developing erythroid cells (cattle) (human) (human) ** R23 HL-21128-03 ATP utilization in platelet contractile ** ROTHL-09902-14 Comparative study of coagulation and ** ROIHL-16675-06 Human urinary erythropoietin collection mechanisms (human, rabbits) vascular disease (animals) ** ROIHL-16720-03 Platelet aggregation (human) ** R23 HL-21129-03 The antisickling effects of imidoesters ** ROTHL-10036-14 Biology of red cell antigen-antibody ** ROIHL-16757-05 'Autoimmune' thrombocytopenia (monkey) ** RO1 HL-21139-03 Molecular biology of factor XIII (human) reaction (human) ** ROIHL-16872-05 Antihemophilic factor (human) ** R23 HL-21208-03 Structure-function relationships of human ** ROIHL-10567-13 Erythropoietin--Immunoassay and ** ROIHL-16931-05 Red cell storage and transtusion factor VIII characterization (human, dogs) (human, animals) ** ROI HL-21379-02 Structure of factor VIII-Von Willebrand ** ROIHL-10880-14 Purification of human erythropoietin for ** ROIHL-16955-06 Heparin, blood coagulation and lipid protein (human) research use metabolism (human) ROI HL-21431-03 Factor II antigen and coagulant activity ** ROIHL-11154-13 Blood group antigens and antibodies ** ROIHL-17513-05 Role of PF-4 in detecting and promoting (human, animals) (human) thrombosis (human, primates) ** ROI HL-21469-02 Active transport and effect of CA00 in ** ROIHL-11172-13 Physiology and biochemistry of ** ROIHL-17729-05 Stimulus-response coupling in platelets sickle cell (human) fibrinolytic enzymes (human, animals) (human) ** ROI HL-21487-02 Molecular characterization of ** ROIHL-11775-12 Platelet mechanisms in disease (human, ** ROIHL-17881-16 Biosynthesis and degradation of blood Glanzmann's thrombasthenia (human) primates) group substances (human) ** R23 HL-21490-03 Studies of enzymes in human platelet ** ROIHL-11880-11 Physiology and pathology of blood ** ROIHL-17964-05 The alternate pathway for fibrinolysis membranes platelets (human, dogs) (human) ** ROI HL-21543-03 Structure-function relation of blood ** ROIHL-12820-10 In vitro regulation of prothrombin ** ROIHL-18012-05 Cellular defects in nocturnal clotting proteins (rabbits) activation hemoglobinuria (human) ** ROI HL-21544-03 ** ROIHL-12944-10 Proteins of coagulation and Hageman Enzymatic and biochemical studies on ROTHL-18030-05 The role of contractile proteins in factor pathways (human, goats) blood cells (human) ** ROI HL-21560-01 ** RO1HL-12972-10 platelets (human, rabbits) Siderosis--Chelation therapy and Glutathione deficiency in red cells ** ROIHL-18068-03 Chemistry and activity of homologous mechanisms (rats) (sheep, dogs) ** R23 HL-21730-02 •* ROIHL-12994.10 heparin fractions (rodents) Wagll--A new vWD deficient antigen The Rh complex of red cells (human) ** ROIHL-18082-03 ** ROIHL-13155-09 Erythrocyte phosphates and vertebrate (human) ** ROI HL-21988-02 defibrination Biochemistry of human pla telet ** ROIHL-18284-05 ** ROIHL-13160-09 chemotaxis Human thrombin (also cattle) Aging erythrocytes--Bio-recognition and elimination (monkeys) ** ROI HL-22035-02 Molecular modification of heparin by ROTHL-13198-22 Blood coagulation--Physico-chemical ** ROIHL-18333-06 Throm bogenesis and hemostatic balance chemical means (sheep) properties (human, cattle) ** ROIHL-13336-10 (rabbits, human) ** ROI HL-22119-02 Biochemistry of platelet function in Biochemistry and physiology of human ** ROIHL-18435-03 platelets Properties of thrombin and Ac-globulin thrombosis and cell growth (rabbits) ** ROIHL-13423-09 ** RO1 HL-22227-02 A new source of hyaluronid ase and ** ROIHL-18551-03 and plasmin (human) Spectrin, actin, lipid and red cell anticoagulants (leeches) ** ROI HL-22289-02 •* ROIHL-13591-07 membrane structure Endothelial cell mediated fibrinolysis Structure of fibers of sickle cell ** ROIHL-18586-03 hemoglobin (human) Role of platelet lipids in hemostasis and (rabbits) ** ROIHL-13629-10 ** ROI HL-22355-02 thrombosis (human) Hemorrhagic diseases (human) Purification, structure and function of ** ROIHL-13881-08 The American Red Cross National ** ROIHL.186 18-05 Purification and function of human HMW factor VIII (human) kininogen ** ROI HL-22410-01 Fractionation Center ADP-induced NAO influx linked to platelet ** ROIHL-14020-07 Characterization of contractile proteins in ** ROIHL-18650-03 Platelet collagen interaction (human) aggregation (human) platelets (human) ROIHL-18672-03 Dynamics of clot structure formation ** ROI HL-22451-01 Regulation of megakaryopo iesis (human, ** ROIHL-14131-19 Abnormal hemoglobin syndromes (human) mice) (human) ** ROIHL-18834-05 Metal-dependent complex formation in ** ROI HL-22471-02 Biochemistry of prothrombin quick ** ROTHL-14344-08 Platelet function and adenine nucleotide blood coagulation (human, cattle) (human) metabolism (human) ** ROIHL-18852-04 Biochemical studies on the blood ** ROI HL-22479-01 Iron chelators delivery in red cell ghosts ** ROIHL-14595-08 Primary disorders of platelet function coagulation process (human, cattle) (rats) (human, rats) ** ROIHL-18859-03 Biochemistry of human factor XI (human) ** ROI HL-22502-02 Role of phosphoinositides in human ** ROIHL-14637-06 Thrombopoietin--immunoassay and ROIHL-18935-03 Platelets, fibrinogen, soluble fibrin platelet secretion characterization (mice) interaction (human) ** ROI HL-22505-02 Molecular pathology of fibrinogen and ** ROTHL-14697-08 Role of platelet membranes in ** ROIHL-18937-04 Cyclic nucleotides and calcium in factor XIII (human, animals) hemostasis (human) platelets (human) •* R23 HL-22621-02 Blood cell mediated pulmonary (human) ** ROIHL-14739-07 The role of leukocytes in thrombotic ** ROIHL-19131-05 Hypercoagulability and the heparin • ROI HL-22642-01 Fibrinogen proteolysis in hemostasis and disease (human, dogs) antithrombin mechanism (human) thrombosis (human) (contd) *Excludes routine methodology OR covers only general projects which preclude indexing at the specific level. M Grant has subprojects describing specific research aspects. Page 9Page 10
HEMAGGLUTININS (ANTIBODY) ** ROIHL-19267-03 Serial comparative study of Von SEE IMMUNOLOGY, ANTIBODIES, HEMAGGLUTININS anticoagulants (rats) Willebrand's disease (human) ** ROIHL-14890-08 Platelet prostaglandins (human, rabbits) ** ROI HL-19270-03 Effects of erythropoiesis on platelets and HEMAGGLUTININS (PLANT) ** ROIHL-14992-08 Mechanism of thrombin action (human) hemostasis (rats) SEE PLANTS PROTEINS, LECTINS ** ROIHL-15226-07 Interaction of blood cells with fibrinogen ** ROIHL-19278-04 Biophysics/biochemistry of 1 degree and fibrin (human, animals) platelet aggregation (human) HEMATOCRIT ** ROIHL-15230-06 Molecular basis of V Willebrand's disease ** ROI HL-19282-04 Regulation of the activation of human SEE BLOOD (HEMATOLOGIC) TESTS, BLOOD CELL COUNT* and hemophilia (human, cattle) factor x and 11 HEMATOLOGIC AGENTS ** ROIHL-15335-07 Blood platelet interactions with ** ROI HL-19323-04 Studies of platelet microtubule protein aggregants (animals) ** ROI HL-19333-04 SEE BLOOD AND RE DRUGS (GENERAL) Hematopoietic chimerism (mice, monkey) ** ROIHL-15474-07 Structure and function of the ROI HL-19646-04 An immunologic study of hemoglobin HEMATOLOGIC TESTS antihemophilic factor (human, cattle) variation in man SEE BLOOD (HEMATOLOGIC) TESTS* ** ROIHL-15491-07 Blood coagulation--Platelet-plasma ** ROI HL-19767-02 Pathochemistry of fibrinogen (humans) protein interaction (human) ** ROI HL-19933-03 Membrane and red cell dysfunction in HEMATOLOGY ** ROIHL-15615-07 Structure-function studies of human hemolytic anemia (human) SEE BLOOD AND RE SYSTEM, HEMATOLOGY factor VIII/VWF ** ROI HL-19996-03 Role of membrane proteins in platelet HEMATOLOGY STUDY SECTION ** ROIHL-15616-05 Platelet membrane proteins in function (human, rabbits) ** ROI HL-20014-03 ** ROIHL-01601-31 aggregation (human) Radioimmunoassay of hyper and Blood coagulation and hemorrhagic ** ROIHL-15619-06 disease (horseshoe crabs) Regulation of prothrombin synthesis in hypocoagulable states (rabbits) ** ROI HL-20074-03 ** ROIHL-01648-32 cultured cells (rats) Structure and function of amidinated Blood coagulation and hemophilia (dogs, ** ROIHL-15647-07 swine) Hematopoietic studies of cyclic human hemoglobin ** ROI HL-20092-03 ** ROIHL-01661-28 hematopoiesis (dogs) Structural and biological properties of Hemostatic mechanisms (human) ** ROIHL-0221224 ** ROIHL-15685-06 Coagulation of blood (human) Hemopoietic regulators produced in cell fibrinogen (human, rabbits) ** ROTHL-02254-24 ** ROI HL-20114-03 Collagen-platelet interaction and human disease (human, animals) ** ROIHL-15690-08 Hydrolytic enzymes of blood in health aorta collagen (human) ** ROIHL-02262-23 ** ROI HL-20140-03 Mechanisms regulating plasma proteins and disease (human, animals) Glycoproteins of platelet membrane and and solutes (human, dogs) ** ROIHL-15728-07 The carbohydrate of the blood-clotting platelet function (human) ** ROIHL-02799-22 ** ROI HL-20141-03 Abnormal hemoglobins (human) glycoproteins (mammals) Biochemical approaches to management ** ROIHL-03357-22 Extrarenal erythropoietin and its ** ROIHL-15793-06 Molecular aspects of erythrocyte of iron overload (human, sheep, dogs) membrane resealing (human) ** ROI HL-20142-03 production (rats, rabbits, mice) Functional studies of abnormal human ** ROIHL-03424-22 Formation and properties of prothrombin ** ROIHL-15817-07 Plasminogen activators from tissues hemoglobins derivatives (human, animals) (human, pig, cattle) ** ROIHL-20218-03 Fibrinogen catabolism and intravascular ** ROIHL-04366-21 Plasminogen-Activation and structure** ROIHL-15887-06 Enzymes of blood coagulation and coagulation (human) function relations (mammals, birds) fibrinolysis (human) ** ROI HL-20303-04 Cholesterol distribution in erythrocyte * ROIHL-04612-21 Feedback between red cell production ** ROIHL-16150-06 Primary structure of prothrombin (cattle, membrane (human) and oxygen transport (rabbits, rats) human) ** ROI HL-20317-03 Procoagulant lipoproteins-- Biochemistry ** ROIHL-05168-20 Inhomogencity of hemoglobin types ** ROIHL-16238-06 Protein structure in coagulation and and bioactivity (goats, rabbits) (human) fibrinolysis (human) ** RO1 HL-20577-04 The mechanism of action of vitamin K ** ROIHL-05351-19 Blood group antigens and antibodies ** ROIHL-16346-10 Enzyme assay for blood clotting (human) ** ROI HL-20750-02 Studies in sickle cell disea se (human) (human, rabbits, sheep) ** ROIHL-16355-06 Reactions of thrombin and collagen with ** ROI HL-20826-03 Meg akaryocyte proliferation and its ** ROIHL-05791-19 Structure and function in hemoglobins platelets (human) control (mice) (human) ** ROIHL-16361-04 Fibrin complexes in intermediary ** ROI HL-20846-03 Purification of bovine plasminogen ** ROIHL-06242-19 Kinetic studies of blood (human) coagulation (human) proactivator ** ROIHL-06950-18 Red cell metabolism (human, ROTHL16375-05 Investigation of hemoglobin S properties ** ROI HL-20920-02 Control of hemoglobin synthesis (baboon) vertebrates) (human) ** ROI HL-20925-02 The acetylation of fetal hemoglobin ** ROIHL-07379-14 Structure and function of fibrinogen ** ROIHL-16633-05 Chemistry and biology of factor IX (human) (human) activator (human, mice, rats) ** ROI HL-20971-11 Membrane glycoproteins of platelets and ** ROZHL-07652-14 Destruction of red blood cells in ** ROIHL-16634-14 Function of platelets and coagulation leukocytes (human) hemolytic anemias (human, guinea pigs) tactors (human) ** ROI HL-21113-02 Control mechanisms in coagulation ** ROIHL-09163-14 Control mechanisms in hemostasis ** ROIHL-16654-07 Regulation in developing erythroid cells (cattle) (human) (human) ** R23 HL-21128-03 ATP utilization in platelet contractile ** ROTHL-09902-14 Comparative study of coagulation and ** ROIHL-16675-06 Human urinary erythropoietin collection mechanisms (human, rabbits) vascular disease (animals) ** ROIHL-16720-03 Platelet aggregation (human) ** R23 HL-21129-03 The antisickling effects of imidoesters ** ROTHL-10036-14 Biology of red cell antigen-antibody ** ROIHL-16757-05 'Autoimmune' thrombocytopenia (monkey) ** RO1 HL-21139-03 Molecular biology of factor XIII (human) reaction (human) ** ROIHL-16872-05 Antihemophilic factor (human) ** R23 HL-21208-03 Structure-function relationships of human ** ROIHL-10567-13 Erythropoietin--Immunoassay and ** ROIHL-16931-05 Red cell storage and transtusion factor VIII characterization (human, dogs) (human, animals) ** ROI HL-21379-02 Structure of factor VIII-Von Willebrand ** ROIHL-10880-14 Purification of human erythropoietin for ** ROIHL-16955-06 Heparin, blood coagulation and lipid protein (human) research use metabolism (human) ROI HL-21431-03 Factor II antigen and coagulant activity ** ROIHL-11154-13 Blood group antigens and antibodies ** ROIHL-17513-05 Role of PF-4 in detecting and promoting (human, animals) (human) thrombosis (human, primates) ** ROI HL-21469-02 Active transport and effect of CA00 in ** ROIHL-11172-13 Physiology and biochemistry of ** ROIHL-17729-05 Stimulus-response coupling in platelets sickle cell (human) fibrinolytic enzymes (human, animals) (human) ** ROI HL-21487-02 Molecular characterization of ** ROIHL-11775-12 Platelet mechanisms in disease (human, ** ROIHL-17881-16 Biosynthesis and degradation of blood Glanzmann's thrombasthenia (human) primates) group substances (human) ** R23 HL-21490-03 Studies of enzymes in human platelet ** ROIHL-11880-11 Physiology and pathology of blood ** ROIHL-17964-05 The alternate pathway for fibrinolysis membranes platelets (human, dogs) (human) ** ROI HL-21543-03 Structure-function relation of blood ** ROIHL-12820-10 In vitro regulation of prothrombin ** ROIHL-18012-05 Cellular defects in nocturnal clotting proteins (rabbits) activation hemoglobinuria (human) ** ROI HL-21544-03 ** ROIHL-12944-10 Proteins of coagulation and Hageman Enzymatic and biochemical studies on ROTHL-18030-05 The role of contractile proteins in factor pathways (human, goats) blood cells (human) ** ROI HL-21560-01 ** RO1HL-12972-10 platelets (human, rabbits) Siderosis--Chelation therapy and Glutathione deficiency in red cells ** ROIHL-18068-03 Chemistry and activity of homologous mechanisms (rats) (sheep, dogs) ** R23 HL-21730-02 •* ROIHL-12994.10 heparin fractions (rodents) Wagll--A new vWD deficient antigen The Rh complex of red cells (human) ** ROIHL-18082-03 ** ROIHL-13155-09 Erythrocyte phosphates and vertebrate (human) ** ROI HL-21988-02 defibrination Biochemistry of human pla telet ** ROIHL-18284-05 ** ROIHL-13160-09 chemotaxis Human thrombin (also cattle) Aging erythrocytes--Bio-recognition and elimination (monkeys) ** ROI HL-22035-02 Molecular modification of heparin by ROTHL-13198-22 Blood coagulation--Physico-chemical ** ROIHL-18333-06 Throm bogenesis and hemostatic balance chemical means (sheep) properties (human, cattle) ** ROIHL-13336-10 (rabbits, human) ** ROI HL-22119-02 Biochemistry of platelet function in Biochemistry and physiology of human ** ROIHL-18435-03 platelets Properties of thrombin and Ac-globulin thrombosis and cell growth (rabbits) ** ROIHL-13423-09 ** RO1 HL-22227-02 A new source of hyaluronid ase and ** ROIHL-18551-03 and plasmin (human) Spectrin, actin, lipid and red cell anticoagulants (leeches) ** ROI HL-22289-02 •* ROIHL-13591-07 membrane structure Endothelial cell mediated fibrinolysis Structure of fibers of sickle cell ** ROIHL-18586-03 hemoglobin (human) Role of platelet lipids in hemostasis and (rabbits) ** ROIHL-13629-10 ** ROI HL-22355-02 thrombosis (human) Hemorrhagic diseases (human) Purification, structure and function of ** ROIHL-13881-08 The American Red Cross National ** ROIHL.186 18-05 Purification and function of human HMW factor VIII (human) kininogen ** ROI HL-22410-01 Fractionation Center ADP-induced NAO influx linked to platelet ** ROIHL-14020-07 Characterization of contractile proteins in ** ROIHL-18650-03 Platelet collagen interaction (human) aggregation (human) platelets (human) ROIHL-18672-03 Dynamics of clot structure formation ** ROI HL-22451-01 Regulation of megakaryopo iesis (human, ** ROIHL-14131-19 Abnormal hemoglobin syndromes (human) mice) (human) ** ROIHL-18834-05 Metal-dependent complex formation in ** ROI HL-22471-02 Biochemistry of prothrombin quick ** ROTHL-14344-08 Platelet function and adenine nucleotide blood coagulation (human, cattle) (human) metabolism (human) ** ROIHL-18852-04 Biochemical studies on the blood ** ROI HL-22479-01 Iron chelators delivery in red cell ghosts ** ROIHL-14595-08 Primary disorders of platelet function coagulation process (human, cattle) (rats) (human, rats) ** ROIHL-18859-03 Biochemistry of human factor XI (human) ** ROI HL-22502-02 Role of phosphoinositides in human ** ROIHL-14637-06 Thrombopoietin--immunoassay and ROIHL-18935-03 Platelets, fibrinogen, soluble fibrin platelet secretion characterization (mice) interaction (human) ** ROI HL-22505-02 Molecular pathology of fibrinogen and ** ROTHL-14697-08 Role of platelet membranes in ** ROIHL-18937-04 Cyclic nucleotides and calcium in factor XIII (human, animals) hemostasis (human) platelets (human) •* R23 HL-22621-02 Blood cell mediated pulmonary (human) ** ROIHL-14739-07 The role of leukocytes in thrombotic ** ROIHL-19131-05 Hypercoagulability and the heparin • ROI HL-22642-01 Fibrinogen proteolysis in hemostasis and disease (human, dogs) antithrombin mechanism (human) thrombosis (human) (contd) *Excludes routine methodology OR covers only general projects which preclude indexing at the specific level. M Grant has subprojects describing specific research aspects. Page 11Page 12
HEMAGGLUTININS (ANTIBODY) ** ROIHL-19267-03 Serial comparative study of Von SEE IMMUNOLOGY, ANTIBODIES, HEMAGGLUTININS anticoagulants (rats) Willebrand's disease (human) ** ROIHL-14890-08 Platelet prostaglandins (human, rabbits) ** ROI HL-19270-03 Effects of erythropoiesis on platelets and HEMAGGLUTININS (PLANT) ** ROIHL-14992-08 Mechanism of thrombin action (human) hemostasis (rats) SEE PLANTS PROTEINS, LECTINS ** ROIHL-15226-07 Interaction of blood cells with fibrinogen ** ROIHL-19278-04 Biophysics/biochemistry of 1 degree and fibrin (human, animals) platelet aggregation (human) HEMATOCRIT ** ROIHL-15230-06 Molecular basis of V Willebrand's disease ** ROI HL-19282-04 Regulation of the activation of human SEE BLOOD (HEMATOLOGIC) TESTS, BLOOD CELL COUNT* and hemophilia (human, cattle) factor x and 11 HEMATOLOGIC AGENTS ** ROIHL-15335-07 Blood platelet interactions with ** ROI HL-19323-04 Studies of platelet microtubule protein aggregants (animals) ** ROI HL-19333-04 SEE BLOOD AND RE DRUGS (GENERAL) Hematopoietic chimerism (mice, monkey) ** ROIHL-15474-07 Structure and function of the ROI HL-19646-04 An immunologic study of hemoglobin HEMATOLOGIC TESTS antihemophilic factor (human, cattle) variation in man SEE BLOOD (HEMATOLOGIC) TESTS* ** ROIHL-15491-07 Blood coagulation--Platelet-plasma ** ROI HL-19767-02 Pathochemistry of fibrinogen (humans) protein interaction (human) ** ROI HL-19933-03 Membrane and red cell dysfunction in HEMATOLOGY ** ROIHL-15615-07 Structure-function studies of human hemolytic anemia (human) SEE BLOOD AND RE SYSTEM, HEMATOLOGY factor VIII/VWF ** ROI HL-19996-03 Role of membrane proteins in platelet HEMATOLOGY STUDY SECTION ** ROIHL-15616-05 Platelet membrane proteins in function (human, rabbits) ** ROI HL-20014-03 ** ROIHL-01601-31 aggregation (human) Radioimmunoassay of hyper and Blood coagulation and hemorrhagic ** ROIHL-15619-06 disease (horseshoe crabs) Regulation of prothrombin synthesis in hypocoagulable states (rabbits) ** ROI HL-20074-03 ** ROIHL-01648-32 cultured cells (rats) Structure and function of amidinated Blood coagulation and hemophilia (dogs, ** ROIHL-15647-07 swine) Hematopoietic studies of cyclic human hemoglobin ** ROI HL-20092-03 ** ROIHL-01661-28 hematopoiesis (dogs) Structural and biological properties of Hemostatic mechanisms (human) ** ROIHL-0221224 ** ROIHL-15685-06 Coagulation of blood (human) Hemopoietic regulators produced in cell fibrinogen (human, rabbits) ** ROTHL-02254-24 ** ROI HL-20114-03 Collagen-platelet interaction and human disease (human, animals) ** ROIHL-15690-08 Hydrolytic enzymes of blood in health aorta collagen (human) ** ROIHL-02262-23 ** ROI HL-20140-03 Mechanisms regulating plasma proteins and disease (human, animals) Glycoproteins of platelet membrane and and solutes (human, dogs) ** ROIHL-15728-07 The carbohydrate of the blood-clotting platelet function (human) ** ROIHL-02799-22 ** ROI HL-20141-03 Abnormal hemoglobins (human) glycoproteins (mammals) Biochemical approaches to management ** ROIHL-03357-22 Extrarenal erythropoietin and its ** ROIHL-15793-06 Molecular aspects of erythrocyte of iron overload (human, sheep, dogs) membrane resealing (human) ** ROI HL-20142-03 production (rats, rabbits, mice) Functional studies of abnormal human ** ROIHL-03424-22 Formation and properties of prothrombin ** ROIHL-15817-07 Plasminogen activators from tissues hemoglobins derivatives (human, animals) (human, pig, cattle) ** ROIHL-20218-03 Fibrinogen catabolism and intravascular ** ROIHL-04366-21 Plasminogen-Activation and structure** ROIHL-15887-06 Enzymes of blood coagulation and coagulation (human) function relations (mammals, birds) fibrinolysis (human) ** ROI HL-20303-04 Cholesterol distribution in erythrocyte * ROIHL-04612-21 Feedback between red cell production ** ROIHL-16150-06 Primary structure of prothrombin (cattle, membrane (human) and oxygen transport (rabbits, rats) human) ** ROI HL-20317-03 Procoagulant lipoproteins-- Biochemistry ** ROIHL-05168-20 Inhomogencity of hemoglobin types ** ROIHL-16238-06 Protein structure in coagulation and and bioactivity (goats, rabbits) (human) fibrinolysis (human) ** RO1 HL-20577-04 The mechanism of action of vitamin K ** ROIHL-05351-19 Blood group antigens and antibodies ** ROIHL-16346-10 Enzyme assay for blood clotting (human) ** ROI HL-20750-02 Studies in sickle cell disea se (human) (human, rabbits, sheep) ** ROIHL-16355-06 Reactions of thrombin and collagen with ** ROI HL-20826-03 Meg akaryocyte proliferation and its ** ROIHL-05791-19 Structure and function in hemoglobins platelets (human) control (mice) (human) ** ROIHL-16361-04 Fibrin complexes in intermediary ** ROI HL-20846-03 Purification of bovine plasminogen ** ROIHL-06242-19 Kinetic studies of blood (human) coagulation (human) proactivator ** ROIHL-06950-18 Red cell metabolism (human, ROTHL16375-05 Investigation of hemoglobin S properties ** ROI HL-20920-02 Control of hemoglobin synthesis (baboon) vertebrates) (human) ** ROI HL-20925-02 The acetylation of fetal hemoglobin ** ROIHL-07379-14 Structure and function of fibrinogen ** ROIHL-16633-05 Chemistry and biology of factor IX (human) (human) activator (human, mice, rats) ** ROI HL-20971-11 Membrane glycoproteins of platelets and ** ROZHL-07652-14 Destruction of red blood cells in ** ROIHL-16634-14 Function of platelets and coagulation leukocytes (human) hemolytic anemias (human, guinea pigs) tactors (human) ** ROI HL-21113-02 Control mechanisms in coagulation ** ROIHL-09163-14 Control mechanisms in hemostasis ** ROIHL-16654-07 Regulation in developing erythroid cells (cattle) (human) (human) ** R23 HL-21128-03 ATP utilization in platelet contractile ** ROTHL-09902-14 Comparative study of coagulation and ** ROIHL-16675-06 Human urinary erythropoietin collection mechanisms (human, rabbits) vascular disease (animals) ** ROIHL-16720-03 Platelet aggregation (human) ** R23 HL-21129-03 The antisickling effects of imidoesters ** ROTHL-10036-14 Biology of red cell antigen-antibody ** ROIHL-16757-05 'Autoimmune' thrombocytopenia (monkey) ** RO1 HL-21139-03 Molecular biology of factor XIII (human) reaction (human) ** ROIHL-16872-05 Antihemophilic factor (human) ** R23 HL-21208-03 Structure-function relationships of human ** ROIHL-10567-13 Erythropoietin--Immunoassay and ** ROIHL-16931-05 Red cell storage and transtusion factor VIII characterization (human, dogs) (human, animals) ** ROI HL-21379-02 Structure of factor VIII-Von Willebrand ** ROIHL-10880-14 Purification of human erythropoietin for ** ROIHL-16955-06 Heparin, blood coagulation and lipid protein (human) research use metabolism (human) ROI HL-21431-03 Factor II antigen and coagulant activity ** ROIHL-11154-13 Blood group antigens and antibodies ** ROIHL-17513-05 Role of PF-4 in detecting and promoting (human, animals) (human) thrombosis (human, primates) ** ROI HL-21469-02 Active transport and effect of CA00 in ** ROIHL-11172-13 Physiology and biochemistry of ** ROIHL-17729-05 Stimulus-response coupling in platelets sickle cell (human) fibrinolytic enzymes (human, animals) (human) ** ROI HL-21487-02 Molecular characterization of ** ROIHL-11775-12 Platelet mechanisms in disease (human, ** ROIHL-17881-16 Biosynthesis and degradation of blood Glanzmann's thrombasthenia (human) primates) group substances (human) ** R23 HL-21490-03 Studies of enzymes in human platelet ** ROIHL-11880-11 Physiology and pathology of blood ** ROIHL-17964-05 The alternate pathway for fibrinolysis membranes platelets (human, dogs) (human) ** ROI HL-21543-03 Structure-function relation of blood ** ROIHL-12820-10 In vitro regulation of prothrombin ** ROIHL-18012-05 Cellular defects in nocturnal clotting proteins (rabbits) activation hemoglobinuria (human) ** ROI HL-21544-03 ** ROIHL-12944-10 Proteins of coagulation and Hageman Enzymatic and biochemical studies on ROTHL-18030-05 The role of contractile proteins in factor pathways (human, goats) blood cells (human) ** ROI HL-21560-01 ** RO1HL-12972-10 platelets (human, rabbits) Siderosis--Chelation therapy and Glutathione deficiency in red cells ** ROIHL-18068-03 Chemistry and activity of homologous mechanisms (rats) (sheep, dogs) ** R23 HL-21730-02 •* ROIHL-12994.10 heparin fractions (rodents) Wagll--A new vWD deficient antigen The Rh complex of red cells (human) ** ROIHL-18082-03 ** ROIHL-13155-09 Erythrocyte phosphates and vertebrate (human) ** ROI HL-21988-02 defibrination Biochemistry of human pla telet ** ROIHL-18284-05 ** ROIHL-13160-09 chemotaxis Human thrombin (also cattle) Aging erythrocytes--Bio-recognition and elimination (monkeys) ** ROI HL-22035-02 Molecular modification of heparin by ROTHL-13198-22 Blood coagulation--Physico-chemical ** ROIHL-18333-06 Throm bogenesis and hemostatic balance chemical means (sheep) properties (human, cattle) ** ROIHL-13336-10 (rabbits, human) ** ROI HL-22119-02 Biochemistry of platelet function in Biochemistry and physiology of human ** ROIHL-18435-03 platelets Properties of thrombin and Ac-globulin thrombosis and cell growth (rabbits) ** ROIHL-13423-09 ** RO1 HL-22227-02 A new source of hyaluronid ase and ** ROIHL-18551-03 and plasmin (human) Spectrin, actin, lipid and red cell anticoagulants (leeches) ** ROI HL-22289-02 •* ROIHL-13591-07 membrane structure Endothelial cell mediated fibrinolysis Structure of fibers of sickle cell ** ROIHL-18586-03 hemoglobin (human) Role of platelet lipids in hemostasis and (rabbits) ** ROIHL-13629-10 ** ROI HL-22355-02 thrombosis (human) Hemorrhagic diseases (human) Purification, structure and function of ** ROIHL-13881-08 The American Red Cross National ** ROIHL.186 18-05 Purification and function of human HMW factor VIII (human) kininogen ** ROI HL-22410-01 Fractionation Center ADP-induced NAO influx linked to platelet ** ROIHL-14020-07 Characterization of contractile proteins in ** ROIHL-18650-03 Platelet collagen interaction (human) aggregation (human) platelets (human) ROIHL-18672-03 Dynamics of clot structure formation ** ROI HL-22451-01 Regulation of megakaryopo iesis (human, ** ROIHL-14131-19 Abnormal hemoglobin syndromes (human) mice) (human) ** ROIHL-18834-05 Metal-dependent complex formation in ** ROI HL-22471-02 Biochemistry of prothrombin quick ** ROTHL-14344-08 Platelet function and adenine nucleotide blood coagulation (human, cattle) (human) metabolism (human) ** ROIHL-18852-04 Biochemical studies on the blood ** ROI HL-22479-01 Iron chelators delivery in red cell ghosts ** ROIHL-14595-08 Primary disorders of platelet function coagulation process (human, cattle) (rats) (human, rats) ** ROIHL-18859-03 Biochemistry of human factor XI (human) ** ROI HL-22502-02 Role of phosphoinositides in human ** ROIHL-14637-06 Thrombopoietin--immunoassay and ROIHL-18935-03 Platelets, fibrinogen, soluble fibrin platelet secretion characterization (mice) interaction (human) ** ROI HL-22505-02 Molecular pathology of fibrinogen and ** ROTHL-14697-08 Role of platelet membranes in ** ROIHL-18937-04 Cyclic nucleotides and calcium in factor XIII (human, animals) hemostasis (human) platelets (human) •* R23 HL-22621-02 Blood cell mediated pulmonary (human) ** ROIHL-14739-07 The role of leukocytes in thrombotic ** ROIHL-19131-05 Hypercoagulability and the heparin • ROI HL-22642-01 Fibrinogen proteolysis in hemostasis and disease (human, dogs) antithrombin mechanism (human) thrombosis (human) (contd) *Excludes routine methodology OR covers only general projects which preclude indexing at the specific level. M Grant has subprojects describing specific research aspects. Page 13Page 14
HEMAGGLUTININS (ANTIBODY) ** ROIHL-19267-03 Serial comparative study of Von SEE IMMUNOLOGY, ANTIBODIES, HEMAGGLUTININS anticoagulants (rats) Willebrand's disease (human) ** ROIHL-14890-08 Platelet prostaglandins (human, rabbits) ** ROI HL-19270-03 Effects of erythropoiesis on platelets and HEMAGGLUTININS (PLANT) ** ROIHL-14992-08 Mechanism of thrombin action (human) hemostasis (rats) SEE PLANTS PROTEINS, LECTINS ** ROIHL-15226-07 Interaction of blood cells with fibrinogen ** ROIHL-19278-04 Biophysics/biochemistry of 1 degree and fibrin (human, animals) platelet aggregation (human) HEMATOCRIT ** ROIHL-15230-06 Molecular basis of V Willebrand's disease ** ROI HL-19282-04 Regulation of the activation of human SEE BLOOD (HEMATOLOGIC) TESTS, BLOOD CELL COUNT* and hemophilia (human, cattle) factor x and 11 HEMATOLOGIC AGENTS ** ROIHL-15335-07 Blood platelet interactions with ** ROI HL-19323-04 Studies of platelet microtubule protein aggregants (animals) ** ROI HL-19333-04 SEE BLOOD AND RE DRUGS (GENERAL) Hematopoietic chimerism (mice, monkey) ** ROIHL-15474-07 Structure and function of the ROI HL-19646-04 An immunologic study of hemoglobin HEMATOLOGIC TESTS antihemophilic factor (human, cattle) variation in man SEE BLOOD (HEMATOLOGIC) TESTS* ** ROIHL-15491-07 Blood coagulation--Platelet-plasma ** ROI HL-19767-02 Pathochemistry of fibrinogen (humans) protein interaction (human) ** ROI HL-19933-03 Membrane and red cell dysfunction in HEMATOLOGY ** ROIHL-15615-07 Structure-function studies of human hemolytic anemia (human) SEE BLOOD AND RE SYSTEM, HEMATOLOGY factor VIII/VWF ** ROI HL-19996-03 Role of membrane proteins in platelet HEMATOLOGY STUDY SECTION ** ROIHL-15616-05 Platelet membrane proteins in function (human, rabbits) ** ROI HL-20014-03 ** ROIHL-01601-31 aggregation (human) Radioimmunoassay of hyper and Blood coagulation and hemorrhagic ** ROIHL-15619-06 disease (horseshoe crabs) Regulation of prothrombin synthesis in hypocoagulable states (rabbits) ** ROI HL-20074-03 ** ROIHL-01648-32 cultured cells (rats) Structure and function of amidinated Blood coagulation and hemophilia (dogs, ** ROIHL-15647-07 swine) Hematopoietic studies of cyclic human hemoglobin ** ROI HL-20092-03 ** ROIHL-01661-28 hematopoiesis (dogs) Structural and biological properties of Hemostatic mechanisms (human) ** ROIHL-0221224 ** ROIHL-15685-06 Coagulation of blood (human) Hemopoietic regulators produced in cell fibrinogen (human, rabbits) ** ROTHL-02254-24 ** ROI HL-20114-03 Collagen-platelet interaction and human disease (human, animals) ** ROIHL-15690-08 Hydrolytic enzymes of blood in health aorta collagen (human) ** ROIHL-02262-23 ** ROI HL-20140-03 Mechanisms regulating plasma proteins and disease (human, animals) Glycoproteins of platelet membrane and and solutes (human, dogs) ** ROIHL-15728-07 The carbohydrate of the blood-clotting platelet function (human) ** ROIHL-02799-22 ** ROI HL-20141-03 Abnormal hemoglobins (human) glycoproteins (mammals) Biochemical approaches to management ** ROIHL-03357-22 Extrarenal erythropoietin and its ** ROIHL-15793-06 Molecular aspects of erythrocyte of iron overload (human, sheep, dogs) membrane resealing (human) ** ROI HL-20142-03 production (rats, rabbits, mice) Functional studies of abnormal human ** ROIHL-03424-22 Formation and properties of prothrombin ** ROIHL-15817-07 Plasminogen activators from tissues hemoglobins derivatives (human, animals) (human, pig, cattle) ** ROIHL-20218-03 Fibrinogen catabolism and intravascular ** ROIHL-04366-21 Plasminogen-Activation and structure** ROIHL-15887-06 Enzymes of blood coagulation and coagulation (human) function relations (mammals, birds) fibrinolysis (human) ** ROI HL-20303-04 Cholesterol distribution in erythrocyte * ROIHL-04612-21 Feedback between red cell production ** ROIHL-16150-06 Primary structure of prothrombin (cattle, membrane (human) and oxygen transport (rabbits, rats) human) ** ROI HL-20317-03 Procoagulant lipoproteins-- Biochemistry ** ROIHL-05168-20 Inhomogencity of hemoglobin types ** ROIHL-16238-06 Protein structure in coagulation and and bioactivity (goats, rabbits) (human) fibrinolysis (human) ** RO1 HL-20577-04 The mechanism of action of vitamin K ** ROIHL-05351-19 Blood group antigens and antibodies ** ROIHL-16346-10 Enzyme assay for blood clotting (human) ** ROI HL-20750-02 Studies in sickle cell disea se (human) (human, rabbits, sheep) ** ROIHL-16355-06 Reactions of thrombin and collagen with ** ROI HL-20826-03 Meg akaryocyte proliferation and its ** ROIHL-05791-19 Structure and function in hemoglobins platelets (human) control (mice) (human) ** ROIHL-16361-04 Fibrin complexes in intermediary ** ROI HL-20846-03 Purification of bovine plasminogen ** ROIHL-06242-19 Kinetic studies of blood (human) coagulation (human) proactivator ** ROIHL-06950-18 Red cell metabolism (human, ROTHL16375-05 Investigation of hemoglobin S properties ** ROI HL-20920-02 Control of hemoglobin synthesis (baboon) vertebrates) (human) ** ROI HL-20925-02 The acetylation of fetal hemoglobin ** ROIHL-07379-14 Structure and function of fibrinogen ** ROIHL-16633-05 Chemistry and biology of factor IX (human) (human) activator (human, mice, rats) ** ROI HL-20971-11 Membrane glycoproteins of platelets and ** ROZHL-07652-14 Destruction of red blood cells in ** ROIHL-16634-14 Function of platelets and coagulation leukocytes (human) hemolytic anemias (human, guinea pigs) tactors (human) ** ROI HL-21113-02 Control mechanisms in coagulation ** ROIHL-09163-14 Control mechanisms in hemostasis ** ROIHL-16654-07 Regulation in developing erythroid cells (cattle) (human) (human) ** R23 HL-21128-03 ATP utilization in platelet contractile ** ROTHL-09902-14 Comparative study of coagulation and ** ROIHL-16675-06 Human urinary erythropoietin collection mechanisms (human, rabbits) vascular disease (animals) ** ROIHL-16720-03 Platelet aggregation (human) ** R23 HL-21129-03 The antisickling effects of imidoesters ** ROTHL-10036-14 Biology of red cell antigen-antibody ** ROIHL-16757-05 'Autoimmune' thrombocytopenia (monkey) ** RO1 HL-21139-03 Molecular biology of factor XIII (human) reaction (human) ** ROIHL-16872-05 Antihemophilic factor (human) ** R23 HL-21208-03 Structure-function relationships of human ** ROIHL-10567-13 Erythropoietin--Immunoassay and ** ROIHL-16931-05 Red cell storage and transtusion factor VIII characterization (human, dogs) (human, animals) ** ROI HL-21379-02 Structure of factor VIII-Von Willebrand ** ROIHL-10880-14 Purification of human erythropoietin for ** ROIHL-16955-06 Heparin, blood coagulation and lipid protein (human) research use metabolism (human) ROI HL-21431-03 Factor II antigen and coagulant activity ** ROIHL-11154-13 Blood group antigens and antibodies ** ROIHL-17513-05 Role of PF-4 in detecting and promoting (human, animals) (human) thrombosis (human, primates) ** ROI HL-21469-02 Active transport and effect of CA00 in ** ROIHL-11172-13 Physiology and biochemistry of ** ROIHL-17729-05 Stimulus-response coupling in platelets sickle cell (human) fibrinolytic enzymes (human, animals) (human) ** ROI HL-21487-02 Molecular characterization of ** ROIHL-11775-12 Platelet mechanisms in disease (human, ** ROIHL-17881-16 Biosynthesis and degradation of blood Glanzmann's thrombasthenia (human) primates) group substances (human) ** R23 HL-21490-03 Studies of enzymes in human platelet ** ROIHL-11880-11 Physiology and pathology of blood ** ROIHL-17964-05 The alternate pathway for fibrinolysis membranes platelets (human, dogs) (human) ** ROI HL-21543-03 Structure-function relation of blood ** ROIHL-12820-10 In vitro regulation of prothrombin ** ROIHL-18012-05 Cellular defects in nocturnal clotting proteins (rabbits) activation hemoglobinuria (human) ** ROI HL-21544-03 ** ROIHL-12944-10 Proteins of coagulation and Hageman Enzymatic and biochemical studies on ROTHL-18030-05 The role of contractile proteins in factor pathways (human, goats) blood cells (human) ** ROI HL-21560-01 ** RO1HL-12972-10 platelets (human, rabbits) Siderosis--Chelation therapy and Glutathione deficiency in red cells ** ROIHL-18068-03 Chemistry and activity of homologous mechanisms (rats) (sheep, dogs) ** R23 HL-21730-02 •* ROIHL-12994.10 heparin fractions (rodents) Wagll--A new vWD deficient antigen The Rh complex of red cells (human) ** ROIHL-18082-03 ** ROIHL-13155-09 Erythrocyte phosphates and vertebrate (human) ** ROI HL-21988-02 defibrination Biochemistry of human pla telet ** ROIHL-18284-05 ** ROIHL-13160-09 chemotaxis Human thrombin (also cattle) Aging erythrocytes--Bio-recognition and elimination (monkeys) ** ROI HL-22035-02 Molecular modification of heparin by ROTHL-13198-22 Blood coagulation--Physico-chemical ** ROIHL-18333-06 Throm bogenesis and hemostatic balance chemical means (sheep) properties (human, cattle) ** ROIHL-13336-10 (rabbits, human) ** ROI HL-22119-02 Biochemistry of platelet function in Biochemistry and physiology of human ** ROIHL-18435-03 platelets Properties of thrombin and Ac-globulin thrombosis and cell growth (rabbits) ** ROIHL-13423-09 ** RO1 HL-22227-02 A new source of hyaluronid ase and ** ROIHL-18551-03 and plasmin (human) Spectrin, actin, lipid and red cell anticoagulants (leeches) ** ROI HL-22289-02 •* ROIHL-13591-07 membrane structure Endothelial cell mediated fibrinolysis Structure of fibers of sickle cell ** ROIHL-18586-03 hemoglobin (human) Role of platelet lipids in hemostasis and (rabbits) ** ROIHL-13629-10 ** ROI HL-22355-02 thrombosis (human) Hemorrhagic diseases (human) Purification, structure and function of ** ROIHL-13881-08 The American Red Cross National ** ROIHL.186 18-05 Purification and function of human HMW factor VIII (human) kininogen ** ROI HL-22410-01 Fractionation Center ADP-induced NAO influx linked to platelet ** ROIHL-14020-07 Characterization of contractile proteins in ** ROIHL-18650-03 Platelet collagen interaction (human) aggregation (human) platelets (human) ROIHL-18672-03 Dynamics of clot structure formation ** ROI HL-22451-01 Regulation of megakaryopo iesis (human, ** ROIHL-14131-19 Abnormal hemoglobin syndromes (human) mice) (human) ** ROIHL-18834-05 Metal-dependent complex formation in ** ROI HL-22471-02 Biochemistry of prothrombin quick ** ROTHL-14344-08 Platelet function and adenine nucleotide blood coagulation (human, cattle) (human) metabolism (human) ** ROIHL-18852-04 Biochemical studies on the blood ** ROI HL-22479-01 Iron chelators delivery in red cell ghosts ** ROIHL-14595-08 Primary disorders of platelet function coagulation process (human, cattle) (rats) (human, rats) ** ROIHL-18859-03 Biochemistry of human factor XI (human) ** ROI HL-22502-02 Role of phosphoinositides in human ** ROIHL-14637-06 Thrombopoietin--immunoassay and ROIHL-18935-03 Platelets, fibrinogen, soluble fibrin platelet secretion characterization (mice) interaction (human) ** ROI HL-22505-02 Molecular pathology of fibrinogen and ** ROTHL-14697-08 Role of platelet membranes in ** ROIHL-18937-04 Cyclic nucleotides and calcium in factor XIII (human, animals) hemostasis (human) platelets (human) •* R23 HL-22621-02 Blood cell mediated pulmonary (human) ** ROIHL-14739-07 The role of leukocytes in thrombotic ** ROIHL-19131-05 Hypercoagulability and the heparin • ROI HL-22642-01 Fibrinogen proteolysis in hemostasis and disease (human, dogs) antithrombin mechanism (human) thrombosis (human) (contd) *Excludes routine methodology OR covers only general projects which preclude indexing at the specific level. M Grant has subprojects describing specific research aspects. Page 15Page 16
HEMAGGLUTININS (ANTIBODY) ** ROIHL-19267-03 Serial comparative study of Von SEE IMMUNOLOGY, ANTIBODIES, HEMAGGLUTININS anticoagulants (rats) Willebrand's disease (human) ** ROIHL-14890-08 Platelet prostaglandins (human, rabbits) ** ROI HL-19270-03 Effects of erythropoiesis on platelets and HEMAGGLUTININS (PLANT) ** ROIHL-14992-08 Mechanism of thrombin action (human) hemostasis (rats) SEE PLANTS PROTEINS, LECTINS ** ROIHL-15226-07 Interaction of blood cells with fibrinogen ** ROIHL-19278-04 Biophysics/biochemistry of 1 degree and fibrin (human, animals) platelet aggregation (human) HEMATOCRIT ** ROIHL-15230-06 Molecular basis of V Willebrand's disease ** ROI HL-19282-04 Regulation of the activation of human SEE BLOOD (HEMATOLOGIC) TESTS, BLOOD CELL COUNT* and hemophilia (human, cattle) factor x and 11 HEMATOLOGIC AGENTS ** ROIHL-15335-07 Blood platelet interactions with ** ROI HL-19323-04 Studies of platelet microtubule protein aggregants (animals) ** ROI HL-19333-04 SEE BLOOD AND RE DRUGS (GENERAL) Hematopoietic chimerism (mice, monkey) ** ROIHL-15474-07 Structure and function of the ROI HL-19646-04 An immunologic study of hemoglobin HEMATOLOGIC TESTS antihemophilic factor (human, cattle) variation in man SEE BLOOD (HEMATOLOGIC) TESTS* ** ROIHL-15491-07 Blood coagulation--Platelet-plasma ** ROI HL-19767-02 Pathochemistry of fibrinogen (humans) protein interaction (human) ** ROI HL-19933-03 Membrane and red cell dysfunction in HEMATOLOGY ** ROIHL-15615-07 Structure-function studies of human hemolytic anemia (human) SEE BLOOD AND RE SYSTEM, HEMATOLOGY factor VIII/VWF ** ROI HL-19996-03 Role of membrane proteins in platelet HEMATOLOGY STUDY SECTION ** ROIHL-15616-05 Platelet membrane proteins in function (human, rabbits) ** ROI HL-20014-03 ** ROIHL-01601-31 aggregation (human) Radioimmunoassay of hyper and Blood coagulation and hemorrhagic ** ROIHL-15619-06 disease (horseshoe crabs) Regulation of prothrombin synthesis in hypocoagulable states (rabbits) ** ROI HL-20074-03 ** ROIHL-01648-32 cultured cells (rats) Structure and function of amidinated Blood coagulation and hemophilia (dogs, ** ROIHL-15647-07 swine) Hematopoietic studies of cyclic human hemoglobin ** ROI HL-20092-03 ** ROIHL-01661-28 hematopoiesis (dogs) Structural and biological properties of Hemostatic mechanisms (human) ** ROIHL-0221224 ** ROIHL-15685-06 Coagulation of blood (human) Hemopoietic regulators produced in cell fibrinogen (human, rabbits) ** ROTHL-02254-24 ** ROI HL-20114-03 Collagen-platelet interaction and human disease (human, animals) ** ROIHL-15690-08 Hydrolytic enzymes of blood in health aorta collagen (human) ** ROIHL-02262-23 ** ROI HL-20140-03 Mechanisms regulating plasma proteins and disease (human, animals) Glycoproteins of platelet membrane and and solutes (human, dogs) ** ROIHL-15728-07 The carbohydrate of the blood-clotting platelet function (human) ** ROIHL-02799-22 ** ROI HL-20141-03 Abnormal hemoglobins (human) glycoproteins (mammals) Biochemical approaches to management ** ROIHL-03357-22 Extrarenal erythropoietin and its ** ROIHL-15793-06 Molecular aspects of erythrocyte of iron overload (human, sheep, dogs) membrane resealing (human) ** ROI HL-20142-03 production (rats, rabbits, mice) Functional studies of abnormal human ** ROIHL-03424-22 Formation and properties of prothrombin ** ROIHL-15817-07 Plasminogen activators from tissues hemoglobins derivatives (human, animals) (human, pig, cattle) ** ROIHL-20218-03 Fibrinogen catabolism and intravascular ** ROIHL-04366-21 Plasminogen-Activation and structure** ROIHL-15887-06 Enzymes of blood coagulation and coagulation (human) function relations (mammals, birds) fibrinolysis (human) ** ROI HL-20303-04 Cholesterol distribution in erythrocyte * ROIHL-04612-21 Feedback between red cell production ** ROIHL-16150-06 Primary structure of prothrombin (cattle, membrane (human) and oxygen transport (rabbits, rats) human) ** ROI HL-20317-03 Procoagulant lipoproteins-- Biochemistry ** ROIHL-05168-20 Inhomogencity of hemoglobin types ** ROIHL-16238-06 Protein structure in coagulation and and bioactivity (goats, rabbits) (human) fibrinolysis (human) ** RO1 HL-20577-04 The mechanism of action of vitamin K ** ROIHL-05351-19 Blood group antigens and antibodies ** ROIHL-16346-10 Enzyme assay for blood clotting (human) ** ROI HL-20750-02 Studies in sickle cell disea se (human) (human, rabbits, sheep) ** ROIHL-16355-06 Reactions of thrombin and collagen with ** ROI HL-20826-03 Meg akaryocyte proliferation and its ** ROIHL-05791-19 Structure and function in hemoglobins platelets (human) control (mice) (human) ** ROIHL-16361-04 Fibrin complexes in intermediary ** ROI HL-20846-03 Purification of bovine plasminogen ** ROIHL-06242-19 Kinetic studies of blood (human) coagulation (human) proactivator ** ROIHL-06950-18 Red cell metabolism (human, ROTHL16375-05 Investigation of hemoglobin S properties ** ROI HL-20920-02 Control of hemoglobin synthesis (baboon) vertebrates) (human) ** ROI HL-20925-02 The acetylation of fetal hemoglobin ** ROIHL-07379-14 Structure and function of fibrinogen ** ROIHL-16633-05 Chemistry and biology of factor IX (human) (human) activator (human, mice, rats) ** ROI HL-20971-11 Membrane glycoproteins of platelets and ** ROZHL-07652-14 Destruction of red blood cells in ** ROIHL-16634-14 Function of platelets and coagulation leukocytes (human) hemolytic anemias (human, guinea pigs) tactors (human) ** ROI HL-21113-02 Control mechanisms in coagulation ** ROIHL-09163-14 Control mechanisms in hemostasis ** ROIHL-16654-07 Regulation in developing erythroid cells (cattle) (human) (human) ** R23 HL-21128-03 ATP utilization in platelet contractile ** ROTHL-09902-14 Comparative study of coagulation and ** ROIHL-16675-06 Human urinary erythropoietin collection mechanisms (human, rabbits) vascular disease (animals) ** ROIHL-16720-03 Platelet aggregation (human) ** R23 HL-21129-03 The antisickling effects of imidoesters ** ROTHL-10036-14 Biology of red cell antigen-antibody ** ROIHL-16757-05 'Autoimmune' thrombocytopenia (monkey) ** RO1 HL-21139-03 Molecular biology of factor XIII (human) reaction (human) ** ROIHL-16872-05 Antihemophilic factor (human) ** R23 HL-21208-03 Structure-function relationships of human ** ROIHL-10567-13 Erythropoietin--Immunoassay and ** ROIHL-16931-05 Red cell storage and transtusion factor VIII characterization (human, dogs) (human, animals) ** ROI HL-21379-02 Structure of factor VIII-Von Willebrand ** ROIHL-10880-14 Purification of human erythropoietin for ** ROIHL-16955-06 Heparin, blood coagulation and lipid protein (human) research use metabolism (human) ROI HL-21431-03 Factor II antigen and coagulant activity ** ROIHL-11154-13 Blood group antigens and antibodies ** ROIHL-17513-05 Role of PF-4 in detecting and promoting (human, animals) (human) thrombosis (human, primates) ** ROI HL-21469-02 Active transport and effect of CA00 in ** ROIHL-11172-13 Physiology and biochemistry of ** ROIHL-17729-05 Stimulus-response coupling in platelets sickle cell (human) fibrinolytic enzymes (human, animals) (human) ** ROI HL-21487-02 Molecular characterization of ** ROIHL-11775-12 Platelet mechanisms in disease (human, ** ROIHL-17881-16 Biosynthesis and degradation of blood Glanzmann's thrombasthenia (human) primates) group substances (human) ** R23 HL-21490-03 Studies of enzymes in human platelet ** ROIHL-11880-11 Physiology and pathology of blood ** ROIHL-17964-05 The alternate pathway for fibrinolysis membranes platelets (human, dogs) (human) ** ROI HL-21543-03 Structure-function relation of blood ** ROIHL-12820-10 In vitro regulation of prothrombin ** ROIHL-18012-05 Cellular defects in nocturnal clotting proteins (rabbits) activation hemoglobinuria (human) ** ROI HL-21544-03 ** ROIHL-12944-10 Proteins of coagulation and Hageman Enzymatic and biochemical studies on ROTHL-18030-05 The role of contractile proteins in factor pathways (human, goats) blood cells (human) ** ROI HL-21560-01 ** RO1HL-12972-10 platelets (human, rabbits) Siderosis--Chelation therapy and Glutathione deficiency in red cells ** ROIHL-18068-03 Chemistry and activity of homologous mechanisms (rats) (sheep, dogs) ** R23 HL-21730-02 •* ROIHL-12994.10 heparin fractions (rodents) Wagll--A new vWD deficient antigen The Rh complex of red cells (human) ** ROIHL-18082-03 ** ROIHL-13155-09 Erythrocyte phosphates and vertebrate (human) ** ROI HL-21988-02 defibrination Biochemistry of human pla telet ** ROIHL-18284-05 ** ROIHL-13160-09 chemotaxis Human thrombin (also cattle) Aging erythrocytes--Bio-recognition and elimination (monkeys) ** ROI HL-22035-02 Molecular modification of heparin by ROTHL-13198-22 Blood coagulation--Physico-chemical ** ROIHL-18333-06 Throm bogenesis and hemostatic balance chemical means (sheep) properties (human, cattle) ** ROIHL-13336-10 (rabbits, human) ** ROI HL-22119-02 Biochemistry of platelet function in Biochemistry and physiology of human ** ROIHL-18435-03 platelets Properties of thrombin and Ac-globulin thrombosis and cell growth (rabbits) ** ROIHL-13423-09 ** RO1 HL-22227-02 A new source of hyaluronid ase and ** ROIHL-18551-03 and plasmin (human) Spectrin, actin, lipid and red cell anticoagulants (leeches) ** ROI HL-22289-02 •* ROIHL-13591-07 membrane structure Endothelial cell mediated fibrinolysis Structure of fibers of sickle cell ** ROIHL-18586-03 hemoglobin (human) Role of platelet lipids in hemostasis and (rabbits) ** ROIHL-13629-10 ** ROI HL-22355-02 thrombosis (human) Hemorrhagic diseases (human) Purification, structure and function of ** ROIHL-13881-08 The American Red Cross National ** ROIHL.186 18-05 Purification and function of human HMW factor VIII (human) kininogen ** ROI HL-22410-01 Fractionation Center ADP-induced NAO influx linked to platelet ** ROIHL-14020-07 Characterization of contractile proteins in ** ROIHL-18650-03 Platelet collagen interaction (human) aggregation (human) platelets (human) ROIHL-18672-03 Dynamics of clot structure formation ** ROI HL-22451-01 Regulation of megakaryopo iesis (human, ** ROIHL-14131-19 Abnormal hemoglobin syndromes (human) mice) (human) ** ROIHL-18834-05 Metal-dependent complex formation in ** ROI HL-22471-02 Biochemistry of prothrombin quick ** ROTHL-14344-08 Platelet function and adenine nucleotide blood coagulation (human, cattle) (human) metabolism (human) ** ROIHL-18852-04 Biochemical studies on the blood ** ROI HL-22479-01 Iron chelators delivery in red cell ghosts ** ROIHL-14595-08 Primary disorders of platelet function coagulation process (human, cattle) (rats) (human, rats) ** ROIHL-18859-03 Biochemistry of human factor XI (human) ** ROI HL-22502-02 Role of phosphoinositides in human ** ROIHL-14637-06 Thrombopoietin--immunoassay and ROIHL-18935-03 Platelets, fibrinogen, soluble fibrin platelet secretion characterization (mice) interaction (human) ** ROI HL-22505-02 Molecular pathology of fibrinogen and ** ROTHL-14697-08 Role of platelet membranes in ** ROIHL-18937-04 Cyclic nucleotides and calcium in factor XIII (human, animals) hemostasis (human) platelets (human) •* R23 HL-22621-02 Blood cell mediated pulmonary (human) ** ROIHL-14739-07 The role of leukocytes in thrombotic ** ROIHL-19131-05 Hypercoagulability and the heparin • ROI HL-22642-01 Fibrinogen proteolysis in hemostasis and disease (human, dogs) antithrombin mechanism (human) thrombosis (human) (contd) *Excludes routine methodology OR covers only general projects which preclude indexing at the specific level. M Grant has subprojects describing specific research aspects. Page 17Page 18
HEMAGGLUTININS (ANTIBODY) ** ROIHL-19267-03 Serial comparative study of Von SEE IMMUNOLOGY, ANTIBODIES, HEMAGGLUTININS anticoagulants (rats) Willebrand's disease (human) ** ROIHL-14890-08 Platelet prostaglandins (human, rabbits) ** ROI HL-19270-03 Effects of erythropoiesis on platelets and HEMAGGLUTININS (PLANT) ** ROIHL-14992-08 Mechanism of thrombin action (human) hemostasis (rats) SEE PLANTS PROTEINS, LECTINS ** ROIHL-15226-07 Interaction of blood cells with fibrinogen ** ROIHL-19278-04 Biophysics/biochemistry of 1 degree and fibrin (human, animals) platelet aggregation (human) HEMATOCRIT ** ROIHL-15230-06 Molecular basis of V Willebrand's disease ** ROI HL-19282-04 Regulation of the activation of human SEE BLOOD (HEMATOLOGIC) TESTS, BLOOD CELL COUNT* and hemophilia (human, cattle) factor x and 11 HEMATOLOGIC AGENTS ** ROIHL-15335-07 Blood platelet interactions with ** ROI HL-19323-04 Studies of platelet microtubule protein aggregants (animals) ** ROI HL-19333-04 SEE BLOOD AND RE DRUGS (GENERAL) Hematopoietic chimerism (mice, monkey) ** ROIHL-15474-07 Structure and function of the ROI HL-19646-04 An immunologic study of hemoglobin HEMATOLOGIC TESTS antihemophilic factor (human, cattle) variation in man SEE BLOOD (HEMATOLOGIC) TESTS* ** ROIHL-15491-07 Blood coagulation--Platelet-plasma ** ROI HL-19767-02 Pathochemistry of fibrinogen (humans) protein interaction (human) ** ROI HL-19933-03 Membrane and red cell dysfunction in HEMATOLOGY ** ROIHL-15615-07 Structure-function studies of human hemolytic anemia (human) SEE BLOOD AND RE SYSTEM, HEMATOLOGY factor VIII/VWF ** ROI HL-19996-03 Role of membrane proteins in platelet HEMATOLOGY STUDY SECTION ** ROIHL-15616-05 Platelet membrane proteins in function (human, rabbits) ** ROI HL-20014-03 ** ROIHL-01601-31 aggregation (human) Radioimmunoassay of hyper and Blood coagulation and hemorrhagic ** ROIHL-15619-06 disease (horseshoe crabs) Regulation of prothrombin synthesis in hypocoagulable states (rabbits) ** ROI HL-20074-03 ** ROIHL-01648-32 cultured cells (rats) Structure and function of amidinated Blood coagulation and hemophilia (dogs, ** ROIHL-15647-07 swine) Hematopoietic studies of cyclic human hemoglobin ** ROI HL-20092-03 ** ROIHL-01661-28 hematopoiesis (dogs) Structural and biological properties of Hemostatic mechanisms (human) ** ROIHL-0221224 ** ROIHL-15685-06 Coagulation of blood (human) Hemopoietic regulators produced in cell fibrinogen (human, rabbits) ** ROTHL-02254-24 ** ROI HL-20114-03 Collagen-platelet interaction and human disease (human, animals) ** ROIHL-15690-08 Hydrolytic enzymes of blood in health aorta collagen (human) ** ROIHL-02262-23 ** ROI HL-20140-03 Mechanisms regulating plasma proteins and disease (human, animals) Glycoproteins of platelet membrane and and solutes (human, dogs) ** ROIHL-15728-07 The carbohydrate of the blood-clotting platelet function (human) ** ROIHL-02799-22 ** ROI HL-20141-03 Abnormal hemoglobins (human) glycoproteins (mammals) Biochemical approaches to management ** ROIHL-03357-22 Extrarenal erythropoietin and its ** ROIHL-15793-06 Molecular aspects of erythrocyte of iron overload (human, sheep, dogs) membrane resealing (human) ** ROI HL-20142-03 production (rats, rabbits, mice) Functional studies of abnormal human ** ROIHL-03424-22 Formation and properties of prothrombin ** ROIHL-15817-07 Plasminogen activators from tissues hemoglobins derivatives (human, animals) (human, pig, cattle) ** ROIHL-20218-03 Fibrinogen catabolism and intravascular ** ROIHL-04366-21 Plasminogen-Activation and structure** ROIHL-15887-06 Enzymes of blood coagulation and coagulation (human) function relations (mammals, birds) fibrinolysis (human) ** ROI HL-20303-04 Cholesterol distribution in erythrocyte * ROIHL-04612-21 Feedback between red cell production ** ROIHL-16150-06 Primary structure of prothrombin (cattle, membrane (human) and oxygen transport (rabbits, rats) human) ** ROI HL-20317-03 Procoagulant lipoproteins-- Biochemistry ** ROIHL-05168-20 Inhomogencity of hemoglobin types ** ROIHL-16238-06 Protein structure in coagulation and and bioactivity (goats, rabbits) (human) fibrinolysis (human) ** RO1 HL-20577-04 The mechanism of action of vitamin K ** ROIHL-05351-19 Blood group antigens and antibodies ** ROIHL-16346-10 Enzyme assay for blood clotting (human) ** ROI HL-20750-02 Studies in sickle cell disea se (human) (human, rabbits, sheep) ** ROIHL-16355-06 Reactions of thrombin and collagen with ** ROI HL-20826-03 Meg akaryocyte proliferation and its ** ROIHL-05791-19 Structure and function in hemoglobins platelets (human) control (mice) (human) ** ROIHL-16361-04 Fibrin complexes in intermediary ** ROI HL-20846-03 Purification of bovine plasminogen ** ROIHL-06242-19 Kinetic studies of blood (human) coagulation (human) proactivator ** ROIHL-06950-18 Red cell metabolism (human, ROTHL16375-05 Investigation of hemoglobin S properties ** ROI HL-20920-02 Control of hemoglobin synthesis (baboon) vertebrates) (human) ** ROI HL-20925-02 The acetylation of fetal hemoglobin ** ROIHL-07379-14 Structure and function of fibrinogen ** ROIHL-16633-05 Chemistry and biology of factor IX (human) (human) activator (human, mice, rats) ** ROI HL-20971-11 Membrane glycoproteins of platelets and ** ROZHL-07652-14 Destruction of red blood cells in ** ROIHL-16634-14 Function of platelets and coagulation leukocytes (human) hemolytic anemias (human, guinea pigs) tactors (human) ** ROI HL-21113-02 Control mechanisms in coagulation ** ROIHL-09163-14 Control mechanisms in hemostasis ** ROIHL-16654-07 Regulation in developing erythroid cells (cattle) (human) (human) ** R23 HL-21128-03 ATP utilization in platelet contractile ** ROTHL-09902-14 Comparative study of coagulation and ** ROIHL-16675-06 Human urinary erythropoietin collection mechanisms (human, rabbits) vascular disease (animals) ** ROIHL-16720-03 Platelet aggregation (human) ** R23 HL-21129-03 The antisickling effects of imidoesters ** ROTHL-10036-14 Biology of red cell antigen-antibody ** ROIHL-16757-05 'Autoimmune' thrombocytopenia (monkey) ** RO1 HL-21139-03 Molecular biology of factor XIII (human) reaction (human) ** ROIHL-16872-05 Antihemophilic factor (human) ** R23 HL-21208-03 Structure-function relationships of human ** ROIHL-10567-13 Erythropoietin--Immunoassay and ** ROIHL-16931-05 Red cell storage and transtusion factor VIII characterization (human, dogs) (human, animals) ** ROI HL-21379-02 Structure of factor VIII-Von Willebrand ** ROIHL-10880-14 Purification of human erythropoietin for ** ROIHL-16955-06 Heparin, blood coagulation and lipid protein (human) research use metabolism (human) ROI HL-21431-03 Factor II antigen and coagulant activity ** ROIHL-11154-13 Blood group antigens and antibodies ** ROIHL-17513-05 Role of PF-4 in detecting and promoting (human, animals) (human) thrombosis (human, primates) ** ROI HL-21469-02 Active transport and effect of CA00 in ** ROIHL-11172-13 Physiology and biochemistry of ** ROIHL-17729-05 Stimulus-response coupling in platelets sickle cell (human) fibrinolytic enzymes (human, animals) (human) ** ROI HL-21487-02 Molecular characterization of ** ROIHL-11775-12 Platelet mechanisms in disease (human, ** ROIHL-17881-16 Biosynthesis and degradation of blood Glanzmann's thrombasthenia (human) primates) group substances (human) ** R23 HL-21490-03 Studies of enzymes in human platelet ** ROIHL-11880-11 Physiology and pathology of blood ** ROIHL-17964-05 The alternate pathway for fibrinolysis membranes platelets (human, dogs) (human) ** ROI HL-21543-03 Structure-function relation of blood ** ROIHL-12820-10 In vitro regulation of prothrombin ** ROIHL-18012-05 Cellular defects in nocturnal clotting proteins (rabbits) activation hemoglobinuria (human) ** ROI HL-21544-03 ** ROIHL-12944-10 Proteins of coagulation and Hageman Enzymatic and biochemical studies on ROTHL-18030-05 The role of contractile proteins in factor pathways (human, goats) blood cells (human) ** ROI HL-21560-01 ** RO1HL-12972-10 platelets (human, rabbits) Siderosis--Chelation therapy and Glutathione deficiency in red cells ** ROIHL-18068-03 Chemistry and activity of homologous mechanisms (rats) (sheep, dogs) ** R23 HL-21730-02 •* ROIHL-12994.10 heparin fractions (rodents) Wagll--A new vWD deficient antigen The Rh complex of red cells (human) ** ROIHL-18082-03 ** ROIHL-13155-09 Erythrocyte phosphates and vertebrate (human) ** ROI HL-21988-02 defibrination Biochemistry of human pla telet ** ROIHL-18284-05 ** ROIHL-13160-09 chemotaxis Human thrombin (also cattle) Aging erythrocytes--Bio-recognition and elimination (monkeys) ** ROI HL-22035-02 Molecular modification of heparin by ROTHL-13198-22 Blood coagulation--Physico-chemical ** ROIHL-18333-06 Throm bogenesis and hemostatic balance chemical means (sheep) properties (human, cattle) ** ROIHL-13336-10 (rabbits, human) ** ROI HL-22119-02 Biochemistry of platelet function in Biochemistry and physiology of human ** ROIHL-18435-03 platelets Properties of thrombin and Ac-globulin thrombosis and cell growth (rabbits) ** ROIHL-13423-09 ** RO1 HL-22227-02 A new source of hyaluronid ase and ** ROIHL-18551-03 and plasmin (human) Spectrin, actin, lipid and red cell anticoagulants (leeches) ** ROI HL-22289-02 •* ROIHL-13591-07 membrane structure Endothelial cell mediated fibrinolysis Structure of fibers of sickle cell ** ROIHL-18586-03 hemoglobin (human) Role of platelet lipids in hemostasis and (rabbits) ** ROIHL-13629-10 ** ROI HL-22355-02 thrombosis (human) Hemorrhagic diseases (human) Purification, structure and function of ** ROIHL-13881-08 The American Red Cross National ** ROIHL.186 18-05 Purification and function of human HMW factor VIII (human) kininogen ** ROI HL-22410-01 Fractionation Center ADP-induced NAO influx linked to platelet ** ROIHL-14020-07 Characterization of contractile proteins in ** ROIHL-18650-03 Platelet collagen interaction (human) aggregation (human) platelets (human) ROIHL-18672-03 Dynamics of clot structure formation ** ROI HL-22451-01 Regulation of megakaryopo iesis (human, ** ROIHL-14131-19 Abnormal hemoglobin syndromes (human) mice) (human) ** ROIHL-18834-05 Metal-dependent complex formation in ** ROI HL-22471-02 Biochemistry of prothrombin quick ** ROTHL-14344-08 Platelet function and adenine nucleotide blood coagulation (human, cattle) (human) metabolism (human) ** ROIHL-18852-04 Biochemical studies on the blood ** ROI HL-22479-01 Iron chelators delivery in red cell ghosts ** ROIHL-14595-08 Primary disorders of platelet function coagulation process (human, cattle) (rats) (human, rats) ** ROIHL-18859-03 Biochemistry of human factor XI (human) ** ROI HL-22502-02 Role of phosphoinositides in human ** ROIHL-14637-06 Thrombopoietin--immunoassay and ROIHL-18935-03 Platelets, fibrinogen, soluble fibrin platelet secretion characterization (mice) interaction (human) ** ROI HL-22505-02 Molecular pathology of fibrinogen and ** ROTHL-14697-08 Role of platelet membranes in ** ROIHL-18937-04 Cyclic nucleotides and calcium in factor XIII (human, animals) hemostasis (human) platelets (human) •* R23 HL-22621-02 Blood cell mediated pulmonary (human) ** ROIHL-14739-07 The role of leukocytes in thrombotic ** ROIHL-19131-05 Hypercoagulability and the heparin • ROI HL-22642-01 Fibrinogen proteolysis in hemostasis and disease (human, dogs) antithrombin mechanism (human) thrombosis (human) (contd) *Excludes routine methodology OR covers only general projects which preclude indexing at the specific level. M Grant has subprojects describing specific research aspects. Page 19Page 20
HEMAGGLUTININS (ANTIBODY) ** ROIHL-19267-03 Serial comparative study of Von SEE IMMUNOLOGY, ANTIBODIES, HEMAGGLUTININS anticoagulants (rats) Willebrand's disease (human) ** ROIHL-14890-08 Platelet prostaglandins (human, rabbits) ** ROI HL-19270-03 Effects of erythropoiesis on platelets and HEMAGGLUTININS (PLANT) ** ROIHL-14992-08 Mechanism of thrombin action (human) hemostasis (rats) SEE PLANTS PROTEINS, LECTINS ** ROIHL-15226-07 Interaction of blood cells with fibrinogen ** ROIHL-19278-04 Biophysics/biochemistry of 1 degree and fibrin (human, animals) platelet aggregation (human) HEMATOCRIT ** ROIHL-15230-06 Molecular basis of V Willebrand's disease ** ROI HL-19282-04 Regulation of the activation of human SEE BLOOD (HEMATOLOGIC) TESTS, BLOOD CELL COUNT* and hemophilia (human, cattle) factor x and 11 HEMATOLOGIC AGENTS ** ROIHL-15335-07 Blood platelet interactions with ** ROI HL-19323-04 Studies of platelet microtubule protein aggregants (animals) ** ROI HL-19333-04 SEE BLOOD AND RE DRUGS (GENERAL) Hematopoietic chimerism (mice, monkey) ** ROIHL-15474-07 Structure and function of the ROI HL-19646-04 An immunologic study of hemoglobin HEMATOLOGIC TESTS antihemophilic factor (human, cattle) variation in man SEE BLOOD (HEMATOLOGIC) TESTS* ** ROIHL-15491-07 Blood coagulation--Platelet-plasma ** ROI HL-19767-02 Pathochemistry of fibrinogen (humans) protein interaction (human) ** ROI HL-19933-03 Membrane and red cell dysfunction in HEMATOLOGY ** ROIHL-15615-07 Structure-function studies of human hemolytic anemia (human) SEE BLOOD AND RE SYSTEM, HEMATOLOGY factor VIII/VWF ** ROI HL-19996-03 Role of membrane proteins in platelet HEMATOLOGY STUDY SECTION ** ROIHL-15616-05 Platelet membrane proteins in function (human, rabbits) ** ROI HL-20014-03 ** ROIHL-01601-31 aggregation (human) Radioimmunoassay of hyper and Blood coagulation and hemorrhagic ** ROIHL-15619-06 disease (horseshoe crabs) Regulation of prothrombin synthesis in hypocoagulable states (rabbits) ** ROI HL-20074-03 ** ROIHL-01648-32 cultured cells (rats) Structure and function of amidinated Blood coagulation and hemophilia (dogs, ** ROIHL-15647-07 swine) Hematopoietic studies of cyclic human hemoglobin ** ROI HL-20092-03 ** ROIHL-01661-28 hematopoiesis (dogs) Structural and biological properties of Hemostatic mechanisms (human) ** ROIHL-0221224 ** ROIHL-15685-06 Coagulation of blood (human) Hemopoietic regulators produced in cell fibrinogen (human, rabbits) ** ROTHL-02254-24 ** ROI HL-20114-03 Collagen-platelet interaction and human disease (human, animals) ** ROIHL-15690-08 Hydrolytic enzymes of blood in health aorta collagen (human) ** ROIHL-02262-23 ** ROI HL-20140-03 Mechanisms regulating plasma proteins and disease (human, animals) Glycoproteins of platelet membrane and and solutes (human, dogs) ** ROIHL-15728-07 The carbohydrate of the blood-clotting platelet function (human) ** ROIHL-02799-22 ** ROI HL-20141-03 Abnormal hemoglobins (human) glycoproteins (mammals) Biochemical approaches to management ** ROIHL-03357-22 Extrarenal erythropoietin and its ** ROIHL-15793-06 Molecular aspects of erythrocyte of iron overload (human, sheep, dogs) membrane resealing (human) ** ROI HL-20142-03 production (rats, rabbits, mice) Functional studies of abnormal human ** ROIHL-03424-22 Formation and properties of prothrombin ** ROIHL-15817-07 Plasminogen activators from tissues hemoglobins derivatives (human, animals) (human, pig, cattle) ** ROIHL-20218-03 Fibrinogen catabolism and intravascular ** ROIHL-04366-21 Plasminogen-Activation and structure** ROIHL-15887-06 Enzymes of blood coagulation and coagulation (human) function relations (mammals, birds) fibrinolysis (human) ** ROI HL-20303-04 Cholesterol distribution in erythrocyte * ROIHL-04612-21 Feedback between red cell production ** ROIHL-16150-06 Primary structure of prothrombin (cattle, membrane (human) and oxygen transport (rabbits, rats) human) ** ROI HL-20317-03 Procoagulant lipoproteins-- Biochemistry ** ROIHL-05168-20 Inhomogencity of hemoglobin types ** ROIHL-16238-06 Protein structure in coagulation and and bioactivity (goats, rabbits) (human) fibrinolysis (human) ** RO1 HL-20577-04 The mechanism of action of vitamin K ** ROIHL-05351-19 Blood group antigens and antibodies ** ROIHL-16346-10 Enzyme assay for blood clotting (human) ** ROI HL-20750-02 Studies in sickle cell disea se (human) (human, rabbits, sheep) ** ROIHL-16355-06 Reactions of thrombin and collagen with ** ROI HL-20826-03 Meg akaryocyte proliferation and its ** ROIHL-05791-19 Structure and function in hemoglobins platelets (human) control (mice) (human) ** ROIHL-16361-04 Fibrin complexes in intermediary ** ROI HL-20846-03 Purification of bovine plasminogen ** ROIHL-06242-19 Kinetic studies of blood (human) coagulation (human) proactivator ** ROIHL-06950-18 Red cell metabolism (human, ROTHL16375-05 Investigation of hemoglobin S properties ** ROI HL-20920-02 Control of hemoglobin synthesis (baboon) vertebrates) (human) ** ROI HL-20925-02 The acetylation of fetal hemoglobin ** ROIHL-07379-14 Structure and function of fibrinogen ** ROIHL-16633-05 Chemistry and biology of factor IX (human) (human) activator (human, mice, rats) ** ROI HL-20971-11 Membrane glycoproteins of platelets and ** ROZHL-07652-14 Destruction of red blood cells in ** ROIHL-16634-14 Function of platelets and coagulation leukocytes (human) hemolytic anemias (human, guinea pigs) tactors (human) ** ROI HL-21113-02 Control mechanisms in coagulation ** ROIHL-09163-14 Control mechanisms in hemostasis ** ROIHL-16654-07 Regulation in developing erythroid cells (cattle) (human) (human) ** R23 HL-21128-03 ATP utilization in platelet contractile ** ROTHL-09902-14 Comparative study of coagulation and ** ROIHL-16675-06 Human urinary erythropoietin collection mechanisms (human, rabbits) vascular disease (animals) ** ROIHL-16720-03 Platelet aggregation (human) ** R23 HL-21129-03 The antisickling effects of imidoesters ** ROTHL-10036-14 Biology of red cell antigen-antibody ** ROIHL-16757-05 'Autoimmune' thrombocytopenia (monkey) ** RO1 HL-21139-03 Molecular biology of factor XIII (human) reaction (human) ** ROIHL-16872-05 Antihemophilic factor (human) ** R23 HL-21208-03 Structure-function relationships of human ** ROIHL-10567-13 Erythropoietin--Immunoassay and ** ROIHL-16931-05 Red cell storage and transtusion factor VIII characterization (human, dogs) (human, animals) ** ROI HL-21379-02 Structure of factor VIII-Von Willebrand ** ROIHL-10880-14 Purification of human erythropoietin for ** ROIHL-16955-06 Heparin, blood coagulation and lipid protein (human) research use metabolism (human) ROI HL-21431-03 Factor II antigen and coagulant activity ** ROIHL-11154-13 Blood group antigens and antibodies ** ROIHL-17513-05 Role of PF-4 in detecting and promoting (human, animals) (human) thrombosis (human, primates) ** ROI HL-21469-02 Active transport and effect of CA00 in ** ROIHL-11172-13 Physiology and biochemistry of ** ROIHL-17729-05 Stimulus-response coupling in platelets sickle cell (human) fibrinolytic enzymes (human, animals) (human) ** ROI HL-21487-02 Molecular characterization of ** ROIHL-11775-12 Platelet mechanisms in disease (human, ** ROIHL-17881-16 Biosynthesis and degradation of blood Glanzmann's thrombasthenia (human) primates) group substances (human) ** R23 HL-21490-03 Studies of enzymes in human platelet ** ROIHL-11880-11 Physiology and pathology of blood ** ROIHL-17964-05 The alternate pathway for fibrinolysis membranes platelets (human, dogs) (human) ** ROI HL-21543-03 Structure-function relation of blood ** ROIHL-12820-10 In vitro regulation of prothrombin ** ROIHL-18012-05 Cellular defects in nocturnal clotting proteins (rabbits) activation hemoglobinuria (human) ** ROI HL-21544-03 ** ROIHL-12944-10 Proteins of coagulation and Hageman Enzymatic and biochemical studies on ROTHL-18030-05 The role of contractile proteins in factor pathways (human, goats) blood cells (human) ** ROI HL-21560-01 ** RO1HL-12972-10 platelets (human, rabbits) Siderosis--Chelation therapy and Glutathione deficiency in red cells ** ROIHL-18068-03 Chemistry and activity of homologous mechanisms (rats) (sheep, dogs) ** R23 HL-21730-02 •* ROIHL-12994.10 heparin fractions (rodents) Wagll--A new vWD deficient antigen The Rh complex of red cells (human) ** ROIHL-18082-03 ** ROIHL-13155-09 Erythrocyte phosphates and vertebrate (human) ** ROI HL-21988-02 defibrination Biochemistry of human pla telet ** ROIHL-18284-05 ** ROIHL-13160-09 chemotaxis Human thrombin (also cattle) Aging erythrocytes--Bio-recognition and elimination (monkeys) ** ROI HL-22035-02 Molecular modification of heparin by ROTHL-13198-22 Blood coagulation--Physico-chemical ** ROIHL-18333-06 Throm bogenesis and hemostatic balance chemical means (sheep) properties (human, cattle) ** ROIHL-13336-10 (rabbits, human) ** ROI HL-22119-02 Biochemistry of platelet function in Biochemistry and physiology of human ** ROIHL-18435-03 platelets Properties of thrombin and Ac-globulin thrombosis and cell growth (rabbits) ** ROIHL-13423-09 ** RO1 HL-22227-02 A new source of hyaluronid ase and ** ROIHL-18551-03 and plasmin (human) Spectrin, actin, lipid and red cell anticoagulants (leeches) ** ROI HL-22289-02 •* ROIHL-13591-07 membrane structure Endothelial cell mediated fibrinolysis Structure of fibers of sickle cell ** ROIHL-18586-03 hemoglobin (human) Role of platelet lipids in hemostasis and (rabbits) ** ROIHL-13629-10 ** ROI HL-22355-02 thrombosis (human) Hemorrhagic diseases (human) Purification, structure and function of ** ROIHL-13881-08 The American Red Cross National ** ROIHL.186 18-05 Purification and function of human HMW factor VIII (human) kininogen ** ROI HL-22410-01 Fractionation Center ADP-induced NAO influx linked to platelet ** ROIHL-14020-07 Characterization of contractile proteins in ** ROIHL-18650-03 Platelet collagen interaction (human) aggregation (human) platelets (human) ROIHL-18672-03 Dynamics of clot structure formation ** ROI HL-22451-01 Regulation of megakaryopo iesis (human, ** ROIHL-14131-19 Abnormal hemoglobin syndromes (human) mice) (human) ** ROIHL-18834-05 Metal-dependent complex formation in ** ROI HL-22471-02 Biochemistry of prothrombin quick ** ROTHL-14344-08 Platelet function and adenine nucleotide blood coagulation (human, cattle) (human) metabolism (human) ** ROIHL-18852-04 Biochemical studies on the blood ** ROI HL-22479-01 Iron chelators delivery in red cell ghosts ** ROIHL-14595-08 Primary disorders of platelet function coagulation process (human, cattle) (rats) (human, rats) ** ROIHL-18859-03 Biochemistry of human factor XI (human) ** ROI HL-22502-02 Role of phosphoinositides in human ** ROIHL-14637-06 Thrombopoietin--immunoassay and ROIHL-18935-03 Platelets, fibrinogen, soluble fibrin platelet secretion characterization (mice) interaction (human) ** ROI HL-22505-02 Molecular pathology of fibrinogen and ** ROTHL-14697-08 Role of platelet membranes in ** ROIHL-18937-04 Cyclic nucleotides and calcium in factor XIII (human, animals) hemostasis (human) platelets (human) •* R23 HL-22621-02 Blood cell mediated pulmonary (human) ** ROIHL-14739-07 The role of leukocytes in thrombotic ** ROIHL-19131-05 Hypercoagulability and the heparin • ROI HL-22642-01 Fibrinogen proteolysis in hemostasis and disease (human, dogs) antithrombin mechanism (human) thrombosis (human) (contd) *Excludes routine methodology OR covers only general projects which preclude indexing at the specific level. M Grant has subprojects describing specific research aspects. Page 21Page 22
HEMAGGLUTININS (ANTIBODY) ** ROIHL-19267-03 Serial comparative study of Von SEE IMMUNOLOGY, ANTIBODIES, HEMAGGLUTININS anticoagulants (rats) Willebrand's disease (human) ** ROIHL-14890-08 Platelet prostaglandins (human, rabbits) ** ROI HL-19270-03 Effects of erythropoiesis on platelets and HEMAGGLUTININS (PLANT) ** ROIHL-14992-08 Mechanism of thrombin action (human) hemostasis (rats) SEE PLANTS PROTEINS, LECTINS ** ROIHL-15226-07 Interaction of blood cells with fibrinogen ** ROIHL-19278-04 Biophysics/biochemistry of 1 degree and fibrin (human, animals) platelet aggregation (human) HEMATOCRIT ** ROIHL-15230-06 Molecular basis of V Willebrand's disease ** ROI HL-19282-04 Regulation of the activation of human SEE BLOOD (HEMATOLOGIC) TESTS, BLOOD CELL COUNT* and hemophilia (human, cattle) factor x and 11 HEMATOLOGIC AGENTS ** ROIHL-15335-07 Blood platelet interactions with ** ROI HL-19323-04 Studies of platelet microtubule protein aggregants (animals) ** ROI HL-19333-04 SEE BLOOD AND RE DRUGS (GENERAL) Hematopoietic chimerism (mice, monkey) ** ROIHL-15474-07 Structure and function of the ROI HL-19646-04 An immunologic study of hemoglobin HEMATOLOGIC TESTS antihemophilic factor (human, cattle) variation in man SEE BLOOD (HEMATOLOGIC) TESTS* ** ROIHL-15491-07 Blood coagulation--Platelet-plasma ** ROI HL-19767-02 Pathochemistry of fibrinogen (humans) protein interaction (human) ** ROI HL-19933-03 Membrane and red cell dysfunction in HEMATOLOGY ** ROIHL-15615-07 Structure-function studies of human hemolytic anemia (human) SEE BLOOD AND RE SYSTEM, HEMATOLOGY factor VIII/VWF ** ROI HL-19996-03 Role of membrane proteins in platelet HEMATOLOGY STUDY SECTION ** ROIHL-15616-05 Platelet membrane proteins in function (human, rabbits) ** ROI HL-20014-03 ** ROIHL-01601-31 aggregation (human) Radioimmunoassay of hyper and Blood coagulation and hemorrhagic ** ROIHL-15619-06 disease (horseshoe crabs) Regulation of prothrombin synthesis in hypocoagulable states (rabbits) ** ROI HL-20074-03 ** ROIHL-01648-32 cultured cells (rats) Structure and function of amidinated Blood coagulation and hemophilia (dogs, ** ROIHL-15647-07 swine) Hematopoietic studies of cyclic human hemoglobin ** ROI HL-20092-03 ** ROIHL-01661-28 hematopoiesis (dogs) Structural and biological properties of Hemostatic mechanisms (human) ** ROIHL-0221224 ** ROIHL-15685-06 Coagulation of blood (human) Hemopoietic regulators produced in cell fibrinogen (human, rabbits) ** ROTHL-02254-24 ** ROI HL-20114-03 Collagen-platelet interaction and human disease (human, animals) ** ROIHL-15690-08 Hydrolytic enzymes of blood in health aorta collagen (human) ** ROIHL-02262-23 ** ROI HL-20140-03 Mechanisms regulating plasma proteins and disease (human, animals) Glycoproteins of platelet membrane and and solutes (human, dogs) ** ROIHL-15728-07 The carbohydrate of the blood-clotting platelet function (human) ** ROIHL-02799-22 ** ROI HL-20141-03 Abnormal hemoglobins (human) glycoproteins (mammals) Biochemical approaches to management ** ROIHL-03357-22 Extrarenal erythropoietin and its ** ROIHL-15793-06 Molecular aspects of erythrocyte of iron overload (human, sheep, dogs) membrane resealing (human) ** ROI HL-20142-03 production (rats, rabbits, mice) Functional studies of abnormal human ** ROIHL-03424-22 Formation and properties of prothrombin ** ROIHL-15817-07 Plasminogen activators from tissues hemoglobins derivatives (human, animals) (human, pig, cattle) ** ROIHL-20218-03 Fibrinogen catabolism and intravascular ** ROIHL-04366-21 Plasminogen-Activation and structure** ROIHL-15887-06 Enzymes of blood coagulation and coagulation (human) function relations (mammals, birds) fibrinolysis (human) ** ROI HL-20303-04 Cholesterol distribution in erythrocyte * ROIHL-04612-21 Feedback between red cell production ** ROIHL-16150-06 Primary structure of prothrombin (cattle, membrane (human) and oxygen transport (rabbits, rats) human) ** ROI HL-20317-03 Procoagulant lipoproteins-- Biochemistry ** ROIHL-05168-20 Inhomogencity of hemoglobin types ** ROIHL-16238-06 Protein structure in coagulation and and bioactivity (goats, rabbits) (human) fibrinolysis (human) ** RO1 HL-20577-04 The mechanism of action of vitamin K ** ROIHL-05351-19 Blood group antigens and antibodies ** ROIHL-16346-10 Enzyme assay for blood clotting (human) ** ROI HL-20750-02 Studies in sickle cell disea se (human) (human, rabbits, sheep) ** ROIHL-16355-06 Reactions of thrombin and collagen with ** ROI HL-20826-03 Meg akaryocyte proliferation and its ** ROIHL-05791-19 Structure and function in hemoglobins platelets (human) control (mice) (human) ** ROIHL-16361-04 Fibrin complexes in intermediary ** ROI HL-20846-03 Purification of bovine plasminogen ** ROIHL-06242-19 Kinetic studies of blood (human) coagulation (human) proactivator ** ROIHL-06950-18 Red cell metabolism (human, ROTHL16375-05 Investigation of hemoglobin S properties ** ROI HL-20920-02 Control of hemoglobin synthesis (baboon) vertebrates) (human) ** ROI HL-20925-02 The acetylation of fetal hemoglobin ** ROIHL-07379-14 Structure and function of fibrinogen ** ROIHL-16633-05 Chemistry and biology of factor IX (human) (human) activator (human, mice, rats) ** ROI HL-20971-11 Membrane glycoproteins of platelets and ** ROZHL-07652-14 Destruction of red blood cells in ** ROIHL-16634-14 Function of platelets and coagulation leukocytes (human) hemolytic anemias (human, guinea pigs) tactors (human) ** ROI HL-21113-02 Control mechanisms in coagulation ** ROIHL-09163-14 Control mechanisms in hemostasis ** ROIHL-16654-07 Regulation in developing erythroid cells (cattle) (human) (human) ** R23 HL-21128-03 ATP utilization in platelet contractile ** ROTHL-09902-14 Comparative study of coagulation and ** ROIHL-16675-06 Human urinary erythropoietin collection mechanisms (human, rabbits) vascular disease (animals) ** ROIHL-16720-03 Platelet aggregation (human) ** R23 HL-21129-03 The antisickling effects of imidoesters ** ROTHL-10036-14 Biology of red cell antigen-antibody ** ROIHL-16757-05 'Autoimmune' thrombocytopenia (monkey) ** RO1 HL-21139-03 Molecular biology of factor XIII (human) reaction (human) ** ROIHL-16872-05 Antihemophilic factor (human) ** R23 HL-21208-03 Structure-function relationships of human ** ROIHL-10567-13 Erythropoietin--Immunoassay and ** ROIHL-16931-05 Red cell storage and transtusion factor VIII characterization (human, dogs) (human, animals) ** ROI HL-21379-02 Structure of factor VIII-Von Willebrand ** ROIHL-10880-14 Purification of human erythropoietin for ** ROIHL-16955-06 Heparin, blood coagulation and lipid protein (human) research use metabolism (human) ROI HL-21431-03 Factor II antigen and coagulant activity ** ROIHL-11154-13 Blood group antigens and antibodies ** ROIHL-17513-05 Role of PF-4 in detecting and promoting (human, animals) (human) thrombosis (human, primates) ** ROI HL-21469-02 Active transport and effect of CA00 in ** ROIHL-11172-13 Physiology and biochemistry of ** ROIHL-17729-05 Stimulus-response coupling in platelets sickle cell (human) fibrinolytic enzymes (human, animals) (human) ** ROI HL-21487-02 Molecular characterization of ** ROIHL-11775-12 Platelet mechanisms in disease (human, ** ROIHL-17881-16 Biosynthesis and degradation of blood Glanzmann's thrombasthenia (human) primates) group substances (human) ** R23 HL-21490-03 Studies of enzymes in human platelet ** ROIHL-11880-11 Physiology and pathology of blood ** ROIHL-17964-05 The alternate pathway for fibrinolysis membranes platelets (human, dogs) (human) ** ROI HL-21543-03 Structure-function relation of blood ** ROIHL-12820-10 In vitro regulation of prothrombin ** ROIHL-18012-05 Cellular defects in nocturnal clotting proteins (rabbits) activation hemoglobinuria (human) ** ROI HL-21544-03 ** ROIHL-12944-10 Proteins of coagulation and Hageman Enzymatic and biochemical studies on ROTHL-18030-05 The role of contractile proteins in factor pathways (human, goats) blood cells (human) ** ROI HL-21560-01 ** RO1HL-12972-10 platelets (human, rabbits) Siderosis--Chelation therapy and Glutathione deficiency in red cells ** ROIHL-18068-03 Chemistry and activity of homologous mechanisms (rats) (sheep, dogs) ** R23 HL-21730-02 •* ROIHL-12994.10 heparin fractions (rodents) Wagll--A new vWD deficient antigen The Rh complex of red cells (human) ** ROIHL-18082-03 ** ROIHL-13155-09 Erythrocyte phosphates and vertebrate (human) ** ROI HL-21988-02 defibrination Biochemistry of human pla telet ** ROIHL-18284-05 ** ROIHL-13160-09 chemotaxis Human thrombin (also cattle) Aging erythrocytes--Bio-recognition and elimination (monkeys) ** ROI HL-22035-02 Molecular modification of heparin by ROTHL-13198-22 Blood coagulation--Physico-chemical ** ROIHL-18333-06 Throm bogenesis and hemostatic balance chemical means (sheep) properties (human, cattle) ** ROIHL-13336-10 (rabbits, human) ** ROI HL-22119-02 Biochemistry of platelet function in Biochemistry and physiology of human ** ROIHL-18435-03 platelets Properties of thrombin and Ac-globulin thrombosis and cell growth (rabbits) ** ROIHL-13423-09 ** RO1 HL-22227-02 A new source of hyaluronid ase and ** ROIHL-18551-03 and plasmin (human) Spectrin, actin, lipid and red cell anticoagulants (leeches) ** ROI HL-22289-02 •* ROIHL-13591-07 membrane structure Endothelial cell mediated fibrinolysis Structure of fibers of sickle cell ** ROIHL-18586-03 hemoglobin (human) Role of platelet lipids in hemostasis and (rabbits) ** ROIHL-13629-10 ** ROI HL-22355-02 thrombosis (human) Hemorrhagic diseases (human) Purification, structure and function of ** ROIHL-13881-08 The American Red Cross National ** ROIHL.186 18-05 Purification and function of human HMW factor VIII (human) kininogen ** ROI HL-22410-01 Fractionation Center ADP-induced NAO influx linked to platelet ** ROIHL-14020-07 Characterization of contractile proteins in ** ROIHL-18650-03 Platelet collagen interaction (human) aggregation (human) platelets (human) ROIHL-18672-03 Dynamics of clot structure formation ** ROI HL-22451-01 Regulation of megakaryopo iesis (human, ** ROIHL-14131-19 Abnormal hemoglobin syndromes (human) mice) (human) ** ROIHL-18834-05 Metal-dependent complex formation in ** ROI HL-22471-02 Biochemistry of prothrombin quick ** ROTHL-14344-08 Platelet function and adenine nucleotide blood coagulation (human, cattle) (human) metabolism (human) ** ROIHL-18852-04 Biochemical studies on the blood ** ROI HL-22479-01 Iron chelators delivery in red cell ghosts ** ROIHL-14595-08 Primary disorders of platelet function coagulation process (human, cattle) (rats) (human, rats) ** ROIHL-18859-03 Biochemistry of human factor XI (human) ** ROI HL-22502-02 Role of phosphoinositides in human ** ROIHL-14637-06 Thrombopoietin--immunoassay and ROIHL-18935-03 Platelets, fibrinogen, soluble fibrin platelet secretion characterization (mice) interaction (human) ** ROI HL-22505-02 Molecular pathology of fibrinogen and ** ROTHL-14697-08 Role of platelet membranes in ** ROIHL-18937-04 Cyclic nucleotides and calcium in factor XIII (human, animals) hemostasis (human) platelets (human) •* R23 HL-22621-02 Blood cell mediated pulmonary (human) ** ROIHL-14739-07 The role of leukocytes in thrombotic ** ROIHL-19131-05 Hypercoagulability and the heparin • ROI HL-22642-01 Fibrinogen proteolysis in hemostasis and disease (human, dogs) antithrombin mechanism (human) thrombosis (human) (contd) *Excludes routine methodology OR covers only general projects which preclude indexing at the specific level. M Grant has subprojects describing specific research aspects. Page 23Page 24
HEMAGGLUTININS (ANTIBODY) ** ROIHL-19267-03 Serial comparative study of Von SEE IMMUNOLOGY, ANTIBODIES, HEMAGGLUTININS anticoagulants (rats) Willebrand's disease (human) ** ROIHL-14890-08 Platelet prostaglandins (human, rabbits) ** ROI HL-19270-03 Effects of erythropoiesis on platelets and HEMAGGLUTININS (PLANT) ** ROIHL-14992-08 Mechanism of thrombin action (human) hemostasis (rats) SEE PLANTS PROTEINS, LECTINS ** ROIHL-15226-07 Interaction of blood cells with fibrinogen ** ROIHL-19278-04 Biophysics/biochemistry of 1 degree and fibrin (human, animals) platelet aggregation (human) HEMATOCRIT ** ROIHL-15230-06 Molecular basis of V Willebrand's disease ** ROI HL-19282-04 Regulation of the activation of human SEE BLOOD (HEMATOLOGIC) TESTS, BLOOD CELL COUNT* and hemophilia (human, cattle) factor x and 11 HEMATOLOGIC AGENTS ** ROIHL-15335-07 Blood platelet interactions with ** ROI HL-19323-04 Studies of platelet microtubule protein aggregants (animals) ** ROI HL-19333-04 SEE BLOOD AND RE DRUGS (GENERAL) Hematopoietic chimerism (mice, monkey) ** ROIHL-15474-07 Structure and function of the ROI HL-19646-04 An immunologic study of hemoglobin HEMATOLOGIC TESTS antihemophilic factor (human, cattle) variation in man SEE BLOOD (HEMATOLOGIC) TESTS* ** ROIHL-15491-07 Blood coagulation--Platelet-plasma ** ROI HL-19767-02 Pathochemistry of fibrinogen (humans) protein interaction (human) ** ROI HL-19933-03 Membrane and red cell dysfunction in HEMATOLOGY ** ROIHL-15615-07 Structure-function studies of human hemolytic anemia (human) SEE BLOOD AND RE SYSTEM, HEMATOLOGY factor VIII/VWF ** ROI HL-19996-03 Role of membrane proteins in platelet HEMATOLOGY STUDY SECTION ** ROIHL-15616-05 Platelet membrane proteins in function (human, rabbits) ** ROI HL-20014-03 ** ROIHL-01601-31 aggregation (human) Radioimmunoassay of hyper and Blood coagulation and hemorrhagic ** ROIHL-15619-06 disease (horseshoe crabs) Regulation of prothrombin synthesis in hypocoagulable states (rabbits) ** ROI HL-20074-03 ** ROIHL-01648-32 cultured cells (rats) Structure and function of amidinated Blood coagulation and hemophilia (dogs, ** ROIHL-15647-07 swine) Hematopoietic studies of cyclic human hemoglobin ** ROI HL-20092-03 ** ROIHL-01661-28 hematopoiesis (dogs) Structural and biological properties of Hemostatic mechanisms (human) ** ROIHL-0221224 ** ROIHL-15685-06 Coagulation of blood (human) Hemopoietic regulators produced in cell fibrinogen (human, rabbits) ** ROTHL-02254-24 ** ROI HL-20114-03 Collagen-platelet interaction and human disease (human, animals) ** ROIHL-15690-08 Hydrolytic enzymes of blood in health aorta collagen (human) ** ROIHL-02262-23 ** ROI HL-20140-03 Mechanisms regulating plasma proteins and disease (human, animals) Glycoproteins of platelet membrane and and solutes (human, dogs) ** ROIHL-15728-07 The carbohydrate of the blood-clotting platelet function (human) ** ROIHL-02799-22 ** ROI HL-20141-03 Abnormal hemoglobins (human) glycoproteins (mammals) Biochemical approaches to management ** ROIHL-03357-22 Extrarenal erythropoietin and its ** ROIHL-15793-06 Molecular aspects of erythrocyte of iron overload (human, sheep, dogs) membrane resealing (human) ** ROI HL-20142-03 production (rats, rabbits, mice) Functional studies of abnormal human ** ROIHL-03424-22 Formation and properties of prothrombin ** ROIHL-15817-07 Plasminogen activators from tissues hemoglobins derivatives (human, animals) (human, pig, cattle) ** ROIHL-20218-03 Fibrinogen catabolism and intravascular ** ROIHL-04366-21 Plasminogen-Activation and structure** ROIHL-15887-06 Enzymes of blood coagulation and coagulation (human) function relations (mammals, birds) fibrinolysis (human) ** ROI HL-20303-04 Cholesterol distribution in erythrocyte * ROIHL-04612-21 Feedback between red cell production ** ROIHL-16150-06 Primary structure of prothrombin (cattle, membrane (human) and oxygen transport (rabbits, rats) human) ** ROI HL-20317-03 Procoagulant lipoproteins-- Biochemistry ** ROIHL-05168-20 Inhomogencity of hemoglobin types ** ROIHL-16238-06 Protein structure in coagulation and and bioactivity (goats, rabbits) (human) fibrinolysis (human) ** RO1 HL-20577-04 The mechanism of action of vitamin K ** ROIHL-05351-19 Blood group antigens and antibodies ** ROIHL-16346-10 Enzyme assay for blood clotting (human) ** ROI HL-20750-02 Studies in sickle cell disea se (human) (human, rabbits, sheep) ** ROIHL-16355-06 Reactions of thrombin and collagen with ** ROI HL-20826-03 Meg akaryocyte proliferation and its ** ROIHL-05791-19 Structure and function in hemoglobins platelets (human) control (mice) (human) ** ROIHL-16361-04 Fibrin complexes in intermediary ** ROI HL-20846-03 Purification of bovine plasminogen ** ROIHL-06242-19 Kinetic studies of blood (human) coagulation (human) proactivator ** ROIHL-06950-18 Red cell metabolism (human, ROTHL16375-05 Investigation of hemoglobin S properties ** ROI HL-20920-02 Control of hemoglobin synthesis (baboon) vertebrates) (human) ** ROI HL-20925-02 The acetylation of fetal hemoglobin ** ROIHL-07379-14 Structure and function of fibrinogen ** ROIHL-16633-05 Chemistry and biology of factor IX (human) (human) activator (human, mice, rats) ** ROI HL-20971-11 Membrane glycoproteins of platelets and ** ROZHL-07652-14 Destruction of red blood cells in ** ROIHL-16634-14 Function of platelets and coagulation leukocytes (human) hemolytic anemias (human, guinea pigs) tactors (human) ** ROI HL-21113-02 Control mechanisms in coagulation ** ROIHL-09163-14 Control mechanisms in hemostasis ** ROIHL-16654-07 Regulation in developing erythroid cells (cattle) (human) (human) ** R23 HL-21128-03 ATP utilization in platelet contractile ** ROTHL-09902-14 Comparative study of coagulation and ** ROIHL-16675-06 Human urinary erythropoietin collection mechanisms (human, rabbits) vascular disease (animals) ** ROIHL-16720-03 Platelet aggregation (human) ** R23 HL-21129-03 The antisickling effects of imidoesters ** ROTHL-10036-14 Biology of red cell antigen-antibody ** ROIHL-16757-05 'Autoimmune' thrombocytopenia (monkey) ** RO1 HL-21139-03 Molecular biology of factor XIII (human) reaction (human) ** ROIHL-16872-05 Antihemophilic factor (human) ** R23 HL-21208-03 Structure-function relationships of human ** ROIHL-10567-13 Erythropoietin--Immunoassay and ** ROIHL-16931-05 Red cell storage and transtusion factor VIII characterization (human, dogs) (human, animals) ** ROI HL-21379-02 Structure of factor VIII-Von Willebrand ** ROIHL-10880-14 Purification of human erythropoietin for ** ROIHL-16955-06 Heparin, blood coagulation and lipid protein (human) research use metabolism (human) ROI HL-21431-03 Factor II antigen and coagulant activity ** ROIHL-11154-13 Blood group antigens and antibodies ** ROIHL-17513-05 Role of PF-4 in detecting and promoting (human, animals) (human) thrombosis (human, primates) ** ROI HL-21469-02 Active transport and effect of CA00 in ** ROIHL-11172-13 Physiology and biochemistry of ** ROIHL-17729-05 Stimulus-response coupling in platelets sickle cell (human) fibrinolytic enzymes (human, animals) (human) ** ROI HL-21487-02 Molecular characterization of ** ROIHL-11775-12 Platelet mechanisms in disease (human, ** ROIHL-17881-16 Biosynthesis and degradation of blood Glanzmann's thrombasthenia (human) primates) group substances (human) ** R23 HL-21490-03 Studies of enzymes in human platelet ** ROIHL-11880-11 Physiology and pathology of blood ** ROIHL-17964-05 The alternate pathway for fibrinolysis membranes platelets (human, dogs) (human) ** ROI HL-21543-03 Structure-function relation of blood ** ROIHL-12820-10 In vitro regulation of prothrombin ** ROIHL-18012-05 Cellular defects in nocturnal clotting proteins (rabbits) activation hemoglobinuria (human) ** ROI HL-21544-03 ** ROIHL-12944-10 Proteins of coagulation and Hageman Enzymatic and biochemical studies on ROTHL-18030-05 The role of contractile proteins in factor pathways (human, goats) blood cells (human) ** ROI HL-21560-01 ** RO1HL-12972-10 platelets (human, rabbits) Siderosis--Chelation therapy and Glutathione deficiency in red cells ** ROIHL-18068-03 Chemistry and activity of homologous mechanisms (rats) (sheep, dogs) ** R23 HL-21730-02 •* ROIHL-12994.10 heparin fractions (rodents) Wagll--A new vWD deficient antigen The Rh complex of red cells (human) ** ROIHL-18082-03 ** ROIHL-13155-09 Erythrocyte phosphates and vertebrate (human) ** ROI HL-21988-02 defibrination Biochemistry of human pla telet ** ROIHL-18284-05 ** ROIHL-13160-09 chemotaxis Human thrombin (also cattle) Aging erythrocytes--Bio-recognition and elimination (monkeys) ** ROI HL-22035-02 Molecular modification of heparin by ROTHL-13198-22 Blood coagulation--Physico-chemical ** ROIHL-18333-06 Throm bogenesis and hemostatic balance chemical means (sheep) properties (human, cattle) ** ROIHL-13336-10 (rabbits, human) ** ROI HL-22119-02 Biochemistry of platelet function in Biochemistry and physiology of human ** ROIHL-18435-03 platelets Properties of thrombin and Ac-globulin thrombosis and cell growth (rabbits) ** ROIHL-13423-09 ** RO1 HL-22227-02 A new source of hyaluronid ase and ** ROIHL-18551-03 and plasmin (human) Spectrin, actin, lipid and red cell anticoagulants (leeches) ** ROI HL-22289-02 •* ROIHL-13591-07 membrane structure Endothelial cell mediated fibrinolysis Structure of fibers of sickle cell ** ROIHL-18586-03 hemoglobin (human) Role of platelet lipids in hemostasis and (rabbits) ** ROIHL-13629-10 ** ROI HL-22355-02 thrombosis (human) Hemorrhagic diseases (human) Purification, structure and function of ** ROIHL-13881-08 The American Red Cross National ** ROIHL.186 18-05 Purification and function of human HMW factor VIII (human) kininogen ** ROI HL-22410-01 Fractionation Center ADP-induced NAO influx linked to platelet ** ROIHL-14020-07 Characterization of contractile proteins in ** ROIHL-18650-03 Platelet collagen interaction (human) aggregation (human) platelets (human) ROIHL-18672-03 Dynamics of clot structure formation ** ROI HL-22451-01 Regulation of megakaryopo iesis (human, ** ROIHL-14131-19 Abnormal hemoglobin syndromes (human) mice) (human) ** ROIHL-18834-05 Metal-dependent complex formation in ** ROI HL-22471-02 Biochemistry of prothrombin quick ** ROTHL-14344-08 Platelet function and adenine nucleotide blood coagulation (human, cattle) (human) metabolism (human) ** ROIHL-18852-04 Biochemical studies on the blood ** ROI HL-22479-01 Iron chelators delivery in red cell ghosts ** ROIHL-14595-08 Primary disorders of platelet function coagulation process (human, cattle) (rats) (human, rats) ** ROIHL-18859-03 Biochemistry of human factor XI (human) ** ROI HL-22502-02 Role of phosphoinositides in human ** ROIHL-14637-06 Thrombopoietin--immunoassay and ROIHL-18935-03 Platelets, fibrinogen, soluble fibrin platelet secretion characterization (mice) interaction (human) ** ROI HL-22505-02 Molecular pathology of fibrinogen and ** ROTHL-14697-08 Role of platelet membranes in ** ROIHL-18937-04 Cyclic nucleotides and calcium in factor XIII (human, animals) hemostasis (human) platelets (human) •* R23 HL-22621-02 Blood cell mediated pulmonary (human) ** ROIHL-14739-07 The role of leukocytes in thrombotic ** ROIHL-19131-05 Hypercoagulability and the heparin • ROI HL-22642-01 Fibrinogen proteolysis in hemostasis and disease (human, dogs) antithrombin mechanism (human) thrombosis (human) (contd) *Excludes routine methodology OR covers only general projects which preclude indexing at the specific level. M Grant has subprojects describing specific research aspects. Page 25Page 26
HEMAGGLUTININS (ANTIBODY) ** ROIHL-19267-03 Serial comparative study of Von SEE IMMUNOLOGY, ANTIBODIES, HEMAGGLUTININS anticoagulants (rats) Willebrand's disease (human) ** ROIHL-14890-08 Platelet prostaglandins (human, rabbits) ** ROI HL-19270-03 Effects of erythropoiesis on platelets and HEMAGGLUTININS (PLANT) ** ROIHL-14992-08 Mechanism of thrombin action (human) hemostasis (rats) SEE PLANTS PROTEINS, LECTINS ** ROIHL-15226-07 Interaction of blood cells with fibrinogen ** ROIHL-19278-04 Biophysics/biochemistry of 1 degree and fibrin (human, animals) platelet aggregation (human) HEMATOCRIT ** ROIHL-15230-06 Molecular basis of V Willebrand's disease ** ROI HL-19282-04 Regulation of the activation of human SEE BLOOD (HEMATOLOGIC) TESTS, BLOOD CELL COUNT* and hemophilia (human, cattle) factor x and 11 HEMATOLOGIC AGENTS ** ROIHL-15335-07 Blood platelet interactions with ** ROI HL-19323-04 Studies of platelet microtubule protein aggregants (animals) ** ROI HL-19333-04 SEE BLOOD AND RE DRUGS (GENERAL) Hematopoietic chimerism (mice, monkey) ** ROIHL-15474-07 Structure and function of the ROI HL-19646-04 An immunologic study of hemoglobin HEMATOLOGIC TESTS antihemophilic factor (human, cattle) variation in man SEE BLOOD (HEMATOLOGIC) TESTS* ** ROIHL-15491-07 Blood coagulation--Platelet-plasma ** ROI HL-19767-02 Pathochemistry of fibrinogen (humans) protein interaction (human) ** ROI HL-19933-03 Membrane and red cell dysfunction in HEMATOLOGY ** ROIHL-15615-07 Structure-function studies of human hemolytic anemia (human) SEE BLOOD AND RE SYSTEM, HEMATOLOGY factor VIII/VWF ** ROI HL-19996-03 Role of membrane proteins in platelet HEMATOLOGY STUDY SECTION ** ROIHL-15616-05 Platelet membrane proteins in function (human, rabbits) ** ROI HL-20014-03 ** ROIHL-01601-31 aggregation (human) Radioimmunoassay of hyper and Blood coagulation and hemorrhagic ** ROIHL-15619-06 disease (horseshoe crabs) Regulation of prothrombin synthesis in hypocoagulable states (rabbits) ** ROI HL-20074-03 ** ROIHL-01648-32 cultured cells (rats) Structure and function of amidinated Blood coagulation and hemophilia (dogs, ** ROIHL-15647-07 swine) Hematopoietic studies of cyclic human hemoglobin ** ROI HL-20092-03 ** ROIHL-01661-28 hematopoiesis (dogs) Structural and biological properties of Hemostatic mechanisms (human) ** ROIHL-0221224 ** ROIHL-15685-06 Coagulation of blood (human) Hemopoietic regulators produced in cell fibrinogen (human, rabbits) ** ROTHL-02254-24 ** ROI HL-20114-03 Collagen-platelet interaction and human disease (human, animals) ** ROIHL-15690-08 Hydrolytic enzymes of blood in health aorta collagen (human) ** ROIHL-02262-23 ** ROI HL-20140-03 Mechanisms regulating plasma proteins and disease (human, animals) Glycoproteins of platelet membrane and and solutes (human, dogs) ** ROIHL-15728-07 The carbohydrate of the blood-clotting platelet function (human) ** ROIHL-02799-22 ** ROI HL-20141-03 Abnormal hemoglobins (human) glycoproteins (mammals) Biochemical approaches to management ** ROIHL-03357-22 Extrarenal erythropoietin and its ** ROIHL-15793-06 Molecular aspects of erythrocyte of iron overload (human, sheep, dogs) membrane resealing (human) ** ROI HL-20142-03 production (rats, rabbits, mice) Functional studies of abnormal human ** ROIHL-03424-22 Formation and properties of prothrombin ** ROIHL-15817-07 Plasminogen activators from tissues hemoglobins derivatives (human, animals) (human, pig, cattle) ** ROIHL-20218-03 Fibrinogen catabolism and intravascular ** ROIHL-04366-21 Plasminogen-Activation and structure** ROIHL-15887-06 Enzymes of blood coagulation and coagulation (human) function relations (mammals, birds) fibrinolysis (human) ** ROI HL-20303-04 Cholesterol distribution in erythrocyte * ROIHL-04612-21 Feedback between red cell production ** ROIHL-16150-06 Primary structure of prothrombin (cattle, membrane (human) and oxygen transport (rabbits, rats) human) ** ROI HL-20317-03 Procoagulant lipoproteins-- Biochemistry ** ROIHL-05168-20 Inhomogencity of hemoglobin types ** ROIHL-16238-06 Protein structure in coagulation and and bioactivity (goats, rabbits) (human) fibrinolysis (human) ** RO1 HL-20577-04 The mechanism of action of vitamin K ** ROIHL-05351-19 Blood group antigens and antibodies ** ROIHL-16346-10 Enzyme assay for blood clotting (human) ** ROI HL-20750-02 Studies in sickle cell disea se (human) (human, rabbits, sheep) ** ROIHL-16355-06 Reactions of thrombin and collagen with ** ROI HL-20826-03 Meg akaryocyte proliferation and its ** ROIHL-05791-19 Structure and function in hemoglobins platelets (human) control (mice) (human) ** ROIHL-16361-04 Fibrin complexes in intermediary ** ROI HL-20846-03 Purification of bovine plasminogen ** ROIHL-06242-19 Kinetic studies of blood (human) coagulation (human) proactivator ** ROIHL-06950-18 Red cell metabolism (human, ROTHL16375-05 Investigation of hemoglobin S properties ** ROI HL-20920-02 Control of hemoglobin synthesis (baboon) vertebrates) (human) ** ROI HL-20925-02 The acetylation of fetal hemoglobin ** ROIHL-07379-14 Structure and function of fibrinogen ** ROIHL-16633-05 Chemistry and biology of factor IX (human) (human) activator (human, mice, rats) ** ROI HL-20971-11 Membrane glycoproteins of platelets and ** ROZHL-07652-14 Destruction of red blood cells in ** ROIHL-16634-14 Function of platelets and coagulation leukocytes (human) hemolytic anemias (human, guinea pigs) tactors (human) ** ROI HL-21113-02 Control mechanisms in coagulation ** ROIHL-09163-14 Control mechanisms in hemostasis ** ROIHL-16654-07 Regulation in developing erythroid cells (cattle) (human) (human) ** R23 HL-21128-03 ATP utilization in platelet contractile ** ROTHL-09902-14 Comparative study of coagulation and ** ROIHL-16675-06 Human urinary erythropoietin collection mechanisms (human, rabbits) vascular disease (animals) ** ROIHL-16720-03 Platelet aggregation (human) ** R23 HL-21129-03 The antisickling effects of imidoesters ** ROTHL-10036-14 Biology of red cell antigen-antibody ** ROIHL-16757-05 'Autoimmune' thrombocytopenia (monkey) ** RO1 HL-21139-03 Molecular biology of factor XIII (human) reaction (human) ** ROIHL-16872-05 Antihemophilic factor (human) ** R23 HL-21208-03 Structure-function relationships of human ** ROIHL-10567-13 Erythropoietin--Immunoassay and ** ROIHL-16931-05 Red cell storage and transtusion factor VIII characterization (human, dogs) (human, animals) ** ROI HL-21379-02 Structure of factor VIII-Von Willebrand ** ROIHL-10880-14 Purification of human erythropoietin for ** ROIHL-16955-06 Heparin, blood coagulation and lipid protein (human) research use metabolism (human) ROI HL-21431-03 Factor II antigen and coagulant activity ** ROIHL-11154-13 Blood group antigens and antibodies ** ROIHL-17513-05 Role of PF-4 in detecting and promoting (human, animals) (human) thrombosis (human, primates) ** ROI HL-21469-02 Active transport and effect of CA00 in ** ROIHL-11172-13 Physiology and biochemistry of ** ROIHL-17729-05 Stimulus-response coupling in platelets sickle cell (human) fibrinolytic enzymes (human, animals) (human) ** ROI HL-21487-02 Molecular characterization of ** ROIHL-11775-12 Platelet mechanisms in disease (human, ** ROIHL-17881-16 Biosynthesis and degradation of blood Glanzmann's thrombasthenia (human) primates) group substances (human) ** R23 HL-21490-03 Studies of enzymes in human platelet ** ROIHL-11880-11 Physiology and pathology of blood ** ROIHL-17964-05 The alternate pathway for fibrinolysis membranes platelets (human, dogs) (human) ** ROI HL-21543-03 Structure-function relation of blood ** ROIHL-12820-10 In vitro regulation of prothrombin ** ROIHL-18012-05 Cellular defects in nocturnal clotting proteins (rabbits) activation hemoglobinuria (human) ** ROI HL-21544-03 ** ROIHL-12944-10 Proteins of coagulation and Hageman Enzymatic and biochemical studies on ROTHL-18030-05 The role of contractile proteins in factor pathways (human, goats) blood cells (human) ** ROI HL-21560-01 ** RO1HL-12972-10 platelets (human, rabbits) Siderosis--Chelation therapy and Glutathione deficiency in red cells ** ROIHL-18068-03 Chemistry and activity of homologous mechanisms (rats) (sheep, dogs) ** R23 HL-21730-02 •* ROIHL-12994.10 heparin fractions (rodents) Wagll--A new vWD deficient antigen The Rh complex of red cells (human) ** ROIHL-18082-03 ** ROIHL-13155-09 Erythrocyte phosphates and vertebrate (human) ** ROI HL-21988-02 defibrination Biochemistry of human pla telet ** ROIHL-18284-05 ** ROIHL-13160-09 chemotaxis Human thrombin (also cattle) Aging erythrocytes--Bio-recognition and elimination (monkeys) ** ROI HL-22035-02 Molecular modification of heparin by ROTHL-13198-22 Blood coagulation--Physico-chemical ** ROIHL-18333-06 Throm bogenesis and hemostatic balance chemical means (sheep) properties (human, cattle) ** ROIHL-13336-10 (rabbits, human) ** ROI HL-22119-02 Biochemistry of platelet function in Biochemistry and physiology of human ** ROIHL-18435-03 platelets Properties of thrombin and Ac-globulin thrombosis and cell growth (rabbits) ** ROIHL-13423-09 ** RO1 HL-22227-02 A new source of hyaluronid ase and ** ROIHL-18551-03 and plasmin (human) Spectrin, actin, lipid and red cell anticoagulants (leeches) ** ROI HL-22289-02 •* ROIHL-13591-07 membrane structure Endothelial cell mediated fibrinolysis Structure of fibers of sickle cell ** ROIHL-18586-03 hemoglobin (human) Role of platelet lipids in hemostasis and (rabbits) ** ROIHL-13629-10 ** ROI HL-22355-02 thrombosis (human) Hemorrhagic diseases (human) Purification, structure and function of ** ROIHL-13881-08 The American Red Cross National ** ROIHL.186 18-05 Purification and function of human HMW factor VIII (human) kininogen ** ROI HL-22410-01 Fractionation Center ADP-induced NAO influx linked to platelet ** ROIHL-14020-07 Characterization of contractile proteins in ** ROIHL-18650-03 Platelet collagen interaction (human) aggregation (human) platelets (human) ROIHL-18672-03 Dynamics of clot structure formation ** ROI HL-22451-01 Regulation of megakaryopo iesis (human, ** ROIHL-14131-19 Abnormal hemoglobin syndromes (human) mice) (human) ** ROIHL-18834-05 Metal-dependent complex formation in ** ROI HL-22471-02 Biochemistry of prothrombin quick ** ROTHL-14344-08 Platelet function and adenine nucleotide blood coagulation (human, cattle) (human) metabolism (human) ** ROIHL-18852-04 Biochemical studies on the blood ** ROI HL-22479-01 Iron chelators delivery in red cell ghosts ** ROIHL-14595-08 Primary disorders of platelet function coagulation process (human, cattle) (rats) (human, rats) ** ROIHL-18859-03 Biochemistry of human factor XI (human) ** ROI HL-22502-02 Role of phosphoinositides in human ** ROIHL-14637-06 Thrombopoietin--immunoassay and ROIHL-18935-03 Platelets, fibrinogen, soluble fibrin platelet secretion characterization (mice) interaction (human) ** ROI HL-22505-02 Molecular pathology of fibrinogen and ** ROTHL-14697-08 Role of platelet membranes in ** ROIHL-18937-04 Cyclic nucleotides and calcium in factor XIII (human, animals) hemostasis (human) platelets (human) •* R23 HL-22621-02 Blood cell mediated pulmonary (human) ** ROIHL-14739-07 The role of leukocytes in thrombotic ** ROIHL-19131-05 Hypercoagulability and the heparin • ROI HL-22642-01 Fibrinogen proteolysis in hemostasis and disease (human, dogs) antithrombin mechanism (human) thrombosis (human) (contd) *Excludes routine methodology OR covers only general projects which preclude indexing at the specific level. M Grant has subprojects describing specific research aspects. |
What feature inserts a function that totals the cell above or to the left of the selected cell?
Postagens relacionadas
direito autoral © 2024 comojogaruno Inc.
