The NFL’s schedule release is Thursday night, but that isn’t going to stop us from tracking all the rumors (and confirming some where we can). We know the Buffalo Bills play on Monday night in Week 2, but the rest is still a bit mysterious. Below, you’ll find the Home and Away opponents, plus each week will be listed out along with information relevant to the Bills’ potential opponent and rumors. The table at the bottom is only for confirmed games from a source we trust. Let’s get after it! Bills’ 2022 OpponentsHome Games Away Games Week-by-week InfoWeek 1 Official: The Bills and Rams will tangle on the NFL’s opening night! - We are reporting per sources that this game is “most likely” to be the Bills vs Los Angeles Rams on the NFL’s Opening Night broadcast, Thursday, September 8th. Week 2 - OFFICIALLY ANNOUNCED - Monday, Sept 19, 7:15 PM Eastern vs. Tennessee Titans (Full Story) Week 3 The Bills will play at the Miami Dolphins at 1:00 PM Eastern, per sources. Week 4 The Bills will play at the Baltimore Ravens at 1:00 PM, per sources. - Not the Packers (via The Athletic, Boston Herald) Week 5 The Bills will host the Pittsburgh Steelers at 1:00 PM Eastern, per multiple sources - Officially not the Packers (vs. NYG) Week 6 The Bills will play at the Kansas City Chiefs in a nationally televised late afternoon game, per sources. - Not the Packers (via The Athletic) - Bills vs Chiefs (via 670 Radio Chicago) Week 7 The Bills are on their bye this week, per multiple sources. - Not the Patriots (per NBC Boston and 670 Radio Chicago and Boston Herald) Week 8 The Bills will host the Green Bay Packers on Sunday Night Football, per sources. - Not the Bears (via 670 Radio Chicago) Week 9 The Bills will be in New Jersey to face the Jets in Week 9, per sources. - Not the Bears (via 670 Radio Chicago) Week 10 The Bills host the Minnesota Vikings in Week 10 at 1:00 PM Eastern, per sources. - Officially not the Packers (vs. DAL) Week 11 The Cleveland Browns come to town for an AFC showdown at 1:00 PM Eastern, per sources. - Not the Packers (via The Athletic) Week 12 The Bills and the Lions will kick off Thanksgiving day at 12:30 PM Eastern, per sources. - Persistent but unconfirmed rumors have the Bills on Thanksgiving against the Baltimore Ravens or Detroit Lions. Week 13 The Bills and Patriots will play the week after Thanksgiving on Thursday night, per multiple sources. Week 14 The Jets visit Orchard Park on December 11th for a 1:00 PM kickoff, per sources. - Not the Chiefs (via 670 Radio Chicago) Week 15 The date and time are unknown due to the flexible scheduling, but the Bills will welcome the Dolphins in December, per sources. It could be either Saturday or Sunday. - Not the Packers (via The Athletic) Week 16 The Bills will head to Chicago to face the Bears on Christmas Eve, per multiple sources. - Officially not the Rams (vs. DEN) Week 17 The Bills are on Monday Night Football for their fifth prime-time contest when they face the Cincinnati Bengals in Week 17, per sources. - Not the Packers (via The Athletic) Week 18 Buffalo finishes the season against the New England Patriots, per sources. - Typically an AFC East opponent
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