When food proteins reach the stomach which substance denatures the protein and kills bacteria?

1. Johansson SG, Hourihane JO, Bousquet J, Bruijnzeel-Koomen C, Dreborg S, Haahtela T, et al. A revised nomenclature for allergy. An EAACI position statement from the EAACI nomenclature task force. Allergy. 2001;56:813–24. [PubMed] [Google Scholar]

2. Young E, Stoneham MD, Petruckevitch A, Barton J, Rona R. A population study of food intolerance. Lancet. 1994;343:1127–30. [PubMed] [Google Scholar]

3. Kanny G, Moneret-Vautrin DA, Flabbee J, Beaudouin E, Morisset M, Thevenin F. Population study of food allergy in France. J Allergy Clin Immunol. 2001;108:133–40. [PubMed] [Google Scholar]

4. Sicherer SH, Munoz-Furlong A, Sampson HA. Prevalence of seafood allergy in the United States determined by a random telephone survey. J Allergy Clin Immunol. 2004;114:159–65. [PubMed] [Google Scholar]

5. Sampson HA. Epidemiology of food allergy. Pediatr Allergy Immunol. 1996;7:42–50. [PubMed] [Google Scholar]

6. Grundy J, Matthews S, Bateman B, Dean T, Arshad SH. Rising prevalence of allergy to peanut in children: data from 2 sequential cohorts. J Allergy Clin Immunol. 2002;110:784–9. [PubMed] [Google Scholar]

7. Sicherer SH, Munoz-Furlong A, Sampson HA. Prevalence of peanut and tree nut allergy in the United States determined by means of a random digit dial telephone survey: a 5-year follow-up study. J Allergy Clin Immunol. 2003;112:1203–7. [PubMed] [Google Scholar]

8. Sloane D, Sheffer A. Oral allergy syndrome. Allergy Asthma Proc. 2001;22:321–5. [PubMed] [Google Scholar]

9. Wang J, Sampson HA. Food anaphylaxis. Clin Exp Allergy. 2007;37:651–60. [PubMed] [Google Scholar]

10. Sampson HA. Update on food allergy. J Allergy Clin Immunol. 2004;113:805–20. [PubMed] [Google Scholar]

11. Sicherer SH, Sampson HA. 9 Food allergy. J Allergy Clin Immunol. 2006;117(suppl):S470–5. [PubMed] [Google Scholar]

12. Roberts G, Lack G. Food allergy and asthma—what is the link? Paediatr Respir Rev. 2003;4:205–12. [PubMed] [Google Scholar]

13. Sampson HA. Food anaphylaxis. Br Med Bull. 2000;56:925–35. [PubMed] [Google Scholar]

14. Brown AF, McKinnon D, Chu K. Emergency department anaphylaxis: a review of 142 patients in a single year. J Allergy Clin Immunol. 2001;108:861–6. [PubMed] [Google Scholar]

15. Smit DV, Cameron PA, Rainer TH. Anaphylaxis presentations to an emergency department in Hong Kong: incidence and predictors of biphasic reactions. J Emerg Med. 2005;28:381–8. [PubMed] [Google Scholar]

16. Deplancke B, Gaskins HR. Microbial modulation of innate defense: goblet cells and the intestinal mucus layer. Am J Clin Nutr. 2001;73(suppl):1131S–41S. [PubMed] [Google Scholar]

17. Brandtzaeg P. Mechanisms of gastrointestinal reactions to food. Environ Toxicol Pharmacol. 1997;4:9–24. [PubMed] [Google Scholar]

18. Brandtzaeg P. History of oral tolerance and mucosal immunity. Ann N Y Acad Sci. 1996;778:1–27. [PubMed] [Google Scholar]

19. Brandtzaeg PE. Current understanding of gastrointestinal immunoregulation and its relation to food allergy. Ann N Y Acad Sci. 2002;964:13–45. [PubMed] [Google Scholar]

20. Faria AM, Weiner HL. Oral tolerance and TGF-beta-producing cells. Inflamm Allergy Drug Targets. 2006;5:179–90. [PubMed] [Google Scholar]

21. Faria AM, Weiner HL. Oral tolerance. Immunol Rev. 2005;206:232–59. [PMC free article] [PubMed] [Google Scholar]

22. Blumberg RS, Lencer WI, Zhu X, Kim HS, Claypool S, Balk SP, et al. Antigen presentation by intestinal epithelial cells. Immunol Lett. 1999;69:7–11. [PubMed] [Google Scholar]

23. Bland PW. Gut epithelium: food processor for the mucosal immune system? Gut. 1998;42:455–6. [PMC free article] [PubMed] [Google Scholar]

24. Brunner M, Walzer M. Absorption of undigested proteins in human beings: the absorption of unaltered fish protein in adults. Arch Intern Med. 1928;42:173–9. [Google Scholar]

25. Brunner M, Walzer M. The absorption of undigested proteins in human beings: the absorption of unaltered fish protein in adults. Arch Intern Med. 1928;42:173–9. [Google Scholar]

26. Dirks CG, Pedersen MH, Platzer MH, Bindslev-Jensen C, Skov PS, Poulsen LK. Does absorption across the buccal mucosa explain early onset of food-induced allergic systemic reactions? J Allergy Clin Immunol. 2005;115:1321–3. [PubMed] [Google Scholar]

27. Untersmayr E, Vestergaard H, Malling HJ, Jensen LB, Platzer MH, Boltz-Nitulescu G, et al. Incomplete digestion of codfish represents a risk factor for anaphylaxis in patients with allergy. J Allergy Clin Immunol. 2007;119:711–7. [PMC free article] [PubMed] [Google Scholar]

28. Kimura T, Higaki K. Gastrointestinal transit and drug absorption. Biol Pharm Bull. 2002;25:149–64. [PubMed] [Google Scholar]

29. Paganelli R, Levinsky RJ. Solid phase radioimmunoassay for detection of circulating food protein antigens in human serum. J Immunol Methods. 1980;37:333–41. [PubMed] [Google Scholar]

30. Husby S, Jensenius JC, Svehag SE. Passage of undegraded dietary antigen into the blood of healthy adults. Quantification, estimation of size distribution, and relation of uptake to levels of specific antibodies. Scand J Immunol. 1985;22:83–92. [PubMed] [Google Scholar]

31. Husby S, Foged N, Host A, Svehag SE. Passage of dietary antigens into the blood of children with coeliac disease. Quantification and size distribution of absorbed antigens. Gut. 1987;28:1062–72. [PMC free article] [PubMed] [Google Scholar]

32. Mayer L. Mucosal immunity. Pediatrics. 2003;111:1595–600. [PubMed] [Google Scholar]

33. Schubert ML. Gastric secretion. Curr Opin Gastroenterol. 2007;23:595–601. [PubMed] [Google Scholar]

34. Etherington DJ, Taylor WH. The pepsins from human gastric mucosal extracts. Biochem J. 1970;118:587–94. [PMC free article] [PubMed] [Google Scholar]

35. Tang J, Wong RN. Evolution in the structure and function of aspartic proteases. J Cell Biochem. 1987;33:53–63. [PubMed] [Google Scholar]

36. Richter C, Tanaka T, Yada RY. Mechanism of activation of the gastric aspartic proteinases: pepsinogen, progastricsin and prochymosin. Biochem J. 1998;335(suppl):481–90. [PMC free article] [PubMed] [Google Scholar]

37. Khan AR, James MN. Molecular mechanisms for the conversion of zymogens to active proteolytic enzymes. Protein Sci. 1998;7:815–36. [PMC free article] [PubMed] [Google Scholar]

38. McPhie P. A spectrophotometric investigation of the pepsinogen-pepsin conversion. J Biol Chem. 1972;247:4277–81. [PubMed] [Google Scholar]

39. al-Janabi J, Hartsuck JA, Tang J. Kinetics and mechanism of pepsinogen activation. J Biol Chem. 1972;247:4628–32. [PubMed] [Google Scholar]

40. Samloff IM. Peptic ulcer: the many proteinases of aggression. Gastroenterology. 1989;96:586–95. [PubMed] [Google Scholar]

41. Oka T, Morihara K. Specificity of pepsin: Size and property of the active site. FEBS Lett. 1970;10:222–4. [PubMed] [Google Scholar]

42. Trout GE, Fruton JS. The side-chain specificity of pepsin. Biochemistry. 1969;8:4183–90. [PubMed] [Google Scholar]

43. Erickson RH, Kim YS. Digestion and absorption of dietary protein. Annu Rev Med. 1990;41:133–9. [PubMed] [Google Scholar]

44. Gray GM, Cooper HL. Protein digestion and absorption. Gastroenterology. 1971;61:535–44. [PubMed] [Google Scholar]

45. Sleisenger MH, Kim YS. Protein digestion and absorption. N Engl J Med. 1979;300:659–63. [PubMed] [Google Scholar]

46. York IA, Goldberg AL, Mo XY, Rock KL. Proteolysis and class I major histocompatibility complex antigen presentation. Immunol Rev. 1999;172:49–66. [PubMed] [Google Scholar]

47. Laver WG, Air GM, Webster RG, Smith-Gill SJ. Epitopes on protein antigens: misconceptions and realities. Cell. 1990;61:553–6. [PubMed] [Google Scholar]

48. Aalberse RC. Structural biology of allergens. J Allergy Clin Immunol. 2000;106:228–38. [PubMed] [Google Scholar]

49. Untersmayr E, Szalai K, Riemer AB, Hemmer W, Swoboda I, Hantusch B, et al. Mimotopes identify conformational epitopes on parvalbumin, the major fish allergen. Mol Immunol. 2006;43:1454–61. [PubMed] [Google Scholar]

50. Ganglberger E, Grunberger K, Sponer B, Radauer C, Breiteneder H, Boltz-Nitulescu G, et al. Allergen mimotopes for 3-dimensional epitope search and induction of antibodies inhibiting human IgE. FASEB J. 2000;14:2177–84. [PubMed] [Google Scholar]

51. Hantusch B, Krieger S, Untersmayr E, Scholl I, Knittelfelder R, Flicker S, et al. Mapping of conformational IgE epitopes on Phl p 5a by using mimotopes from a phage display library. J Allergy Clin Immunol. 2004;114:1294–300. [PubMed] [Google Scholar]

52. Szalai K, Fuhrmann J, Pavkov T, Scheidl M, Wallmann J, Bramswig KH, et al. Mimotopes identify conformational B-cell epitopes on the two major house dust mite allergens Der p 1 and Der p 2. Mol Immunol. 2008;45:1308–17. [PubMed] [Google Scholar]

53. Jarvinen KM, Beyer K, Vila L, Chatchatee P, Busse PJ, Sampson HA. B-cell epitopes as a screening instrument for persistent cow's milk allergy. J Allergy Clin Immunol. 2002;110:293–7. [PubMed] [Google Scholar]

54. Schöll I, Kalkura N, Shedziankova Y, Bergmann A, Verdino P, Knittelfelder R, et al. Dimerization of the major birch pollen allergen Bet v 1 is important for its in vivo IgE-cross-linking potential in mice. J Immunol. 2005;175:6645–50. [PubMed] [Google Scholar]

55. Lehrer SB, Ayuso R, Reese G. Current understanding of food allergens. Ann N Y Acad Sci. 2002;964:69–85. [PubMed] [Google Scholar]

56. Bannon GA. What makes a food protein an allergen? Curr Allergy Asthma Rep. 2004;4:43–6. [PubMed] [Google Scholar]

57. Maier I, Okun VM, Pittner F, Lindner W. Changes in peptic digestibility of bovine beta-lactoglobulin as a result of food processing studied by capillary electrophoresis and immunochemical methods. J Chromatogr B Analyt Technol Biomed Life Sci. 2006;841:160–7. [PubMed] [Google Scholar]

58. Sen M, Kopper R, Pons L, Abraham EC, Burks AW, Bannon GA. Protein structure plays a critical role in peanut allergen stability and may determine immunodominant IgE-binding epitopes. J Immunol. 2002;169:882–7. [PubMed] [Google Scholar]

59. Aalberse RC. Food allergens. Environ Toxicol Pharm. 1997;4:55–60. [PubMed] [Google Scholar]

60. Jensen-Jarolim E, Wiedermann U, Ganglberger E, Zurcher A, Stadler BM, Boltz-Nitulescu G, et al. Allergen mimotopes in food enhance type I allergic reactions in mice. FASEB J. 1999;13:1586–92. [PubMed] [Google Scholar]

61. Vieths S, Scheurer S, Ballmer-Weber B. Current understanding of cross-reactivity of food allergens and pollen. Ann N Y Acad Sci. 2002;964:47–68. [PubMed] [Google Scholar]

62. Astwood JD, Leach JN, Fuchs RL. Stability of food allergens to digestion in vitro. Nat Biotechnol. 1996;14:1269–73. [PubMed] [Google Scholar]

63. Hefle SL, Nordlee JA, Taylor SL. Allergenic foods. Crit Rev Food Sci Nutr. 1996;36(suppl):S69–89. [PubMed] [Google Scholar]

64. Taylor SL, Hefle SL. Will genetically modified foods be allergenic? J Allergy Clin Immunol. 2001;107:765–71. [PubMed] [Google Scholar]

65. Nordlee JA, Taylor SL, Townsend JA, Thomas LA, Bush RK. Identification of a Brazil-nut allergen in transgenic soybeans. N Engl J Med. 1996;334:688–92. [PubMed] [Google Scholar]

66. Evaluation of genetically modified foods Available at: www.who.int/foodsafety/publications/biotech/en/ec_jan2001.pdf. Accessed February 10, 2008.

67. Food safety: regulating plant agricultural biotechnology in the United States Available at: http://usinfo.state.gov/products/pubs/archive/biotech. Accessed February 10, 2008.

68. Eiwegger T, Rigby N, Mondoulet L, Bernard H, Krauth MT, Boehm A, et al. Gastro-duodenal digestion products of the major peanut allergen Ara h 1 retain an allergenic potential. Clin Exp Allergy. 2006;36:1281–8. [PubMed] [Google Scholar]

69. Burnett GR, Wickham M, Fillery-Travis A, Robertson JA, Belton PS, Gilbert SM, et al. Interaction between protein allergens and model gastric emulsions. Biochem Soc Trans. 2002;30:916–8. [PubMed] [Google Scholar]

70. Moreno FJ, Mackie AR, Mills EN. Phospholipid interactions protect the milk allergen alpha-lactalbumin from proteolysis during in vitro digestion. J Agric Food Chem. 2005;53:9810–6. [PubMed] [Google Scholar]

71. Yagami T, Haishima Y, Nakamura A, Osuna H, Ikezawa Z. Digestibility of allergens extracted from natural rubber latex and vegetable foods. J Allergy Clin Immunol. 2000;106:752–62. [PubMed] [Google Scholar]

72. Fu TJ, Abbott UR, Hatzos C. Digestibility of food allergens and nonallergenic proteins in simulated gastric fluid and simulated intestinal fluid—a comparative study. J Agric Food Chem. 2002;50:7154–60. [PubMed] [Google Scholar]

73. Fu TJ. Digestion stability as a criterion for protein allergenicity assessment. Ann N Y Acad Sci. 2002;964:99–110. [PubMed] [Google Scholar]

74. Taylor SL. Comment on digestibility of food allergens and nonallergenic proteins in simulated gastric fluid and simulated intestinal fluid—a comparative study. J Agric Food Chem. 2003;51:5183–7. [PubMed] [Google Scholar]

75. Vieths S, Reindl J, Müller U, Hoffmann A, Haustein D. Digestibility of peanut and hazelnut allergens investigated by a simple in vitro procedure. Eur Food Res Technol. 1999;209:379–88. [Google Scholar]

76. Untersmayr E, Schöll I, Swoboda I, Beil WJ, Förster-Waldl E, Walter F, et al. Antacid medication inhibits digestion of dietary proteins and causes food allergy: a fish allergy model in BALB/c mice. J Allergy Clin Immunol. 2003;112:616–23. [PubMed] [Google Scholar]

77. Untersmayr E, Bakos N, Schöll I, Kundi M, Roth-Walter F, Szalai K, et al. Anti-ulcer drugs promote IgE formation toward dietary antigens in adult patients. FASEB J. 2005;19:656–8. [PubMed] [Google Scholar]

78. Untersmayr E, Poulsen LK, Platzer MH, Pedersen MH, Boltz-Nitulescu G, Skov PS, et al. The effects of gastric digestion on codfish allergenicity. J Allergy Clin Immunol. 2005;115:377–82. [PubMed] [Google Scholar]

79. Schöll I, Untersmayr E, Bakos N, Roth-Walter F, Gleiss A, Boltz-Nitulescu G, et al. Antiulcer drugs promote oral sensitization and hypersensitivity to hazelnut allergens in BALB/c mice and humans. Am J Clin Nutr. 2005;81:154–60. [PubMed] [Google Scholar]

80. Schimek EM, Zwolfer B, Briza P, Jahn-Schmid B, Vogel L, Vieths S, et al. Gastrointestinal digestion of Bet v 1-homologous food allergens destroys their mediator-releasing, but not T cell-activating, capacity. J Allergy Clin Immunol. 2005;116:1327–33. [PubMed] [Google Scholar]

81. Ebers DW, Gibbs GE, Smith DI. Gastric acidity on the first day of life. Pediatrics. 1956;18:800–2. [PubMed] [Google Scholar]

82. Avery GB, Randolph JG, Weaver T. Gastric acidity in the first day of life. Pediatrics. 1966;37:1005–7. [PubMed] [Google Scholar]

83. Euler AR, Byrne WJ, Cousins LM, Ament ME, Walsh JH. Increased serum gastrin concentrations and gastric acid hyposecretion in the immediate newborn period. Gastroenterology. 1977;72:1271–3. [PubMed] [Google Scholar]

84. Agunod M, Yamaguchi N, Lopez R, Luhby AL, Glass GB. Correlative study of hydrochloric acid, pepsin, and intrinsic factor secretion in newborns and infants. Am J Dig Dis. 1969;14:400–14. [PubMed] [Google Scholar]

85. Miller RA. Observations on the gastric acidity during the first month of life. Arch Dis Child. 1941;16:22–30. [PMC free article] [PubMed] [Google Scholar]

86. Deren JS. Development of structure and function in the fetal and newborn stomach. Am J Clin Nutr. 1971;24:144–59. [PubMed] [Google Scholar]

87. Alcorn J, McNamara PJ. Pharmacokinetics in the newborn. Adv Drug Deliv Rev. 2003;55:667–86. [PubMed] [Google Scholar]

88. Davies D, James TG. An investigation into the gastric secretion of a hundred normal persons over the age of sixty. Brit J Med. 1930;1:1–14. [Google Scholar]

89. de Witte TJ, Geerdink PJ, Lamers CB, Boerbooms AM, van der Korst JK. Hypochlorhydria and hypergastrinaemia in rheumatoid arthritis. Ann Rheum Dis. 1979;38:14–7. [PMC free article] [PubMed] [Google Scholar]

90. Hosking DJ, Moody F, Stewart IM, Atkinson M. Vagal impairment of gastric secretion in diabetic autonomic neuropathy. BMJ. 1975;2:588–90. [PMC free article] [PubMed] [Google Scholar]

91. Howitz J, Schwartz M. Vitiligo, achlorhydria, and pernicious anaemia. Lancet. 1971;1:1331–4. [PubMed] [Google Scholar]

92. Talley NJ, Zinsmeister AR, Schleck CD, Melton LJ., 3rd Dyspepsia and dyspepsia subgroups: a population-based study. Gastroenterology. 1992;102:1259–68. [PubMed] [Google Scholar]

93. Kay L, Jorgensen T. Epidemiology of upper dyspepsia in a random population. Prevalence, incidence, natural history, and risk factors. Scand J Gastroenterol. 1994;29:2–6. [PubMed] [Google Scholar]

94. Talley NJ, Silverstein MD, Agreus L, Nyren O, Sonnenberg A, Holtmann G. AGA technical review: evaluation of dyspepsia. American Gastroenterological Association. Gastroenterology. 1998;114:582–95. [PubMed] [Google Scholar]

95. Westbrook JI, McIntosh JH, Talley NJ. The impact of dyspepsia definition on prevalence estimates: considerations for future researchers. Scand J Gastroenterol. 2000;35:227–33. [PubMed] [Google Scholar]

96. Lydeard S, Jones R. Factors affecting the decision to consult with dyspepsia: comparison of consulters and non-consulters. J R Coll Gen Pract. 1989;39:495–8. [PMC free article] [PubMed] [Google Scholar]

97. Warndorff DK, Knottnerus JA, Huijnen LG, Starmans R. How well do general practitioners manage dyspepsia? J R Coll Gen Pract. 1989;39:499–502. [PMC free article] [PubMed] [Google Scholar]

98. Heikkinen M, Pikkarainen P, Takala J, Julkunen R. General practitioners' approach to dyspepsia. Survey of consultation frequencies, treatment, and investigations. Scand J Gastroenterol. 1996;31:648–53. [PubMed] [Google Scholar]

99. Sunku B, Marino RV, Sockolow R. A primary care approach to pediatric gastroesophageal reflux. J Am Osteopath Assoc. 2000;100(suppl):S11–5. [PubMed] [Google Scholar]

100. Tolia V, Wuerth A, Thomas R. Gastroesophageal reflux disease: review of presenting symptoms, evaluation, management, and outcome in infants. Dig Dis Sci. 2003;48:1723–9. [PubMed] [Google Scholar]

101. Gold BD. Review article: epidemiology and management of gastro-oesophageal reflux in children. Aliment Pharmacol Ther. 2004;19(suppl 1):22–7. [PubMed] [Google Scholar]

102. Gold BD, Scheiman JM, Sabesin SM, Vitat P. Updates on the management of upper gastrointestinal disorders in the primary care setting: NSAID-related gastropathies and pediatric reflux diseases. J Fam Pract. 2007;56(suppl):S1–11. [PubMed] [Google Scholar]

103. Bashford JN, Norwood J, Chapman SR. Why are patients prescribed proton pump inhibitors? Retrospective analysis of link between morbidity and prescribing in the General Practice Research Database. BMJ. 1998;317:452–6. [PMC free article] [PubMed] [Google Scholar]

104. Westbrook JI, Duggan AE, McIntosh JH. Prescriptions for antiulcer drugs in Australia: volume, trends, and costs. BMJ. 2001;323:1338–9. [PMC free article] [PubMed] [Google Scholar]

105. Marshall JK, Grootendorst PV, O'Brien BJ, Dolovich LR, Holbrook AM, Levy AR. Impact of reference-based pricing for histamine-2 receptor antagonists and restricted access for proton pump inhibitors in British Columbia. CMAJ. 2002;166:1655–62. [PMC free article] [PubMed] [Google Scholar]

106. Lassen A, Hallas J, Schaffalitzky De Muckadell OB. Use of anti-secretory medication: a population-based cohort study. Aliment Pharmacol Ther. 2004;20:577–83. [PubMed] [Google Scholar]

107. Ryder SD, O'Reilly S, Miller RJ, Ross J, Jacyna MR, Levi AJ. Long term acid suppressing treatment in general practice. BMJ. 1994;308:827–30. [PMC free article] [PubMed] [Google Scholar]

108. McCullagh M, Brown C, Bell D, Powell K. Long term acid suppressing treatment. Survey shows variation in practice. BMJ. 1994;308:1238. [PMC free article] [PubMed] [Google Scholar]

109. Boutet R, Wilcock M, MacKenzie I. Survey on repeat prescribing for acid suppression drugs in primary care in Cornwall and the Isles of Scilly. Aliment Pharmacol Ther. 1999;13:813–7. [PubMed] [Google Scholar]

110. Gullotta R, Ferraris L, Cortelezzi C, Minoli G, Prada A, Comin U, et al. Are we correctly using the inhibitors of gastric acid secretion and cytoprotective drugs? Results of a multicentre study. Ital J Gastroenterol Hepatol. 1997;29:325–9. [PubMed] [Google Scholar]

111. Nardino RJ, Vender RJ, Herbert PN. Overuse of acid-suppressive therapy in hospitalized patients. Am J Gastroenterol. 2000;95:3118–22. [PubMed] [Google Scholar]

112. Zink DA, Pohlman M, Barnes M, Cannon ME. Long-term use of acid suppression started inappropriately during hospitalization. Aliment Pharmacol Ther. 2005;21:1203–9. [PubMed] [Google Scholar]

113. Chen TJ, Chou LF, Hwang SJ. Prevalence of anti-ulcer drug use in a Chinese cohort. World J Gastroenterol. 2003;9:1365–9. [PMC free article] [PubMed] [Google Scholar]

114. Statistical registry of pharmaceuticals, Danish Medicines Agency Available at: http://www.laegemiddelstyrelsen.dk/1024/visLSArtikel.asp?artikelID=8479. Accessed January 28, 2008.

115. Untersmayr E, Diesner SC, Jensen-Jarolim E. Acid-suppression: a risk to develop food allergy. In: Koletzko S, editor. Food allergy in childhood. Causes and consequences. SPS Publications; Heilbronn: 2007. pp. 52–65. [Google Scholar]

116. McCarthy DM. Sucralfate. N Engl J Med. 1991;325:1017–25. [PubMed] [Google Scholar]

117. Richardson P, Hawkey CJ, Stack WA. Proton pump inhibitors. Pharmacology and rationale for use in gastrointestinal disorders. Drugs. 1998;56:307–35. [PubMed] [Google Scholar]

118. Aihara T, Nakamura E, Amagase K, Tomita K, Fujishita T, Furutani K, et al. Pharmacological control of gastric acid secretion for the treatment of acid-related peptic disease: past, present, and future. Pharmacol Ther. 2003;98:109–27. [PubMed] [Google Scholar]

119. Prichard PJ, Yeomans ND, Mihaly GW, Jones DB, Buckle PJ, Smallwood RA, et al. Omeprazole: a study of its inhibition of gastric pH and oral pharmacokinetics after morning or evening dosage. Gastroenterology. 1985;88:64–9. [PubMed] [Google Scholar]

120. Tolia V, Fitzgerald J, Hassall E, Huang B, Pilmer B, Kane R., 3rd Safety of lansoprazole in the treatment of gastroesophageal reflux disease in children. J Pediatr Gastroenterol Nutr. 2002;35(suppl 4):S300–7. [PubMed] [Google Scholar]

121. Gold BD, Gunasekaran T, Tolia V, Wetzler G, Conter H, Traxler B, et al. Safety and symptom improvement with esomeprazole in adolescents with gastroesophageal reflux disease. J Pediatr Gastroenterol Nutr. 2007;45:520–9. [PubMed] [Google Scholar]

122. van Zyl J, van Rensburg C, Vieweg W, Fischer R. Efficacy and safety of pantoprazole versus ranitidine in the treatment of patients with symptomatic gastroesophageal reflux disease. Digestion. 2004;70:61–9. [PubMed] [Google Scholar]

123. Richter JE. Review article: the management of heartburn in pregnancy. Aliment Pharmacol Ther. 2005;22:749–57. [PubMed] [Google Scholar]

124. Williams C. Occurrence and significance of gastric colonization during acid-inhibitory therapy. Best Pract Res Clin Gastroenterol. 2001;15:511–21. [PubMed] [Google Scholar]

125. Martinsen TC, Bergh K, Waldum HL. Gastric juice: a barrier against infectious diseases. Basic Clin Pharmacol Toxicol. 2005;96:94–102. [PubMed] [Google Scholar]

126. Leonard J, Marshall JK, Moayyedi P. Systematic review of the risk of enteric infection in patients taking acid suppression. Am J Gastroenterol. 2007;102:2047–57. [PubMed] [Google Scholar]

127. Inglis TJ, Sherratt MJ, Sproat LJ, Gibson JS, Hawkey PM. Gastroduodenal dys-function and bacterial colonisation of the ventilated lung. Lancet. 1993;341:911–3. [PubMed] [Google Scholar]

128. Laheij RJ, Sturkenboom MC, Hassing RJ, Dieleman J, Stricker BH, Jansen JB. Risk of community-acquired pneumonia and use of gastric acid-suppressive drugs. JAMA. 2004;292:1955–60. [PubMed] [Google Scholar]

129. Waldum HL, Brenna E, Sandvik AK. Long-term safety of proton pump inhibitors: risks of gastric neoplasia and infections. Expert Opin Drug Saf. 2002;1:29–38. [PubMed] [Google Scholar]

130. Budagovskaia VN, Voitko NE. Allergic reactions in patients with peptic ulcer; incidence of food and drug allergy. Vopr Pitan. 1984;3:30–3. [PubMed] [Google Scholar]

131. De Lazzari F, Mancin O, Plebani M, Venturi C, Battaglia G, Vianello F, et al. High IgE serum levels and “peptic” ulcers: clinical and functional approach. Ital J Gastroenterol. 1994;26:7–11. [PubMed] [Google Scholar]

132. De Lazzari F, Venturi C, Fregona I, Galliani EA, Bortolami M, Violato D, et al. Specific IgE in the gastric and duodenal mucosa. An epiphenomenon or pathogenetic mechanism of some forms of “peptic” ulcer? Minerva Gastroenterol Dietol. 1994;40:1–9. [PubMed] [Google Scholar]

133. Mancin O, De Lazzari F, Pasqualetti P, Venturi C, Faggian D, Plebani M, et al. Raised levels of IgE and allergic diseases in patients subjected to esophagogastroduodenoscopy. Minerva Dietol Gastroenterol. 1988;34:171–5. [PubMed] [Google Scholar]

134. Permin H, Norgaard A, Norn S, Andersen LP, Nielsen H. IgE-mediated immune response to Helicobacter pylori examined by basophil histamine release in patients with dyspepsia. Inflamm Res. 2000;49(suppl 1):S29–30. [PubMed] [Google Scholar]

135. Liutu M, Kalimo K, Uksila J, Savolainen J. Extraction of IgE-binding components of Helicobacter pylori by immunoblotting analysis in chronic urticaria patients. Int Arch Allergy Immunol. 2001;126:213–7. [PubMed] [Google Scholar]

136. Lauerma AI, Petman L, Makinen-Kiljunen S. IgE-mediated anaphylaxis to antacid. Allergy. 2001;56:580. [PubMed] [Google Scholar]

137. Brewer JM, Conacher M, Hunter CA, Mohrs M, Brombacher F, Alexander J. Aluminium hydroxide adjuvant initiates strong antigen-specific Th2 responses in the absence of IL-4- or IL-13-mediated signaling. J Immunol. 1999;163:6448–54. [PubMed] [Google Scholar]

138. Brunner R, Wallmann J, Szalai K, Karagiannis P, Kopp T, Scheiner O, et al. The impact of aluminium in acid-suppressing drugs on the immune response of BALB/c mice. Clin Exp Allergy. 2007;37:1566–73. [PubMed] [Google Scholar]

139. Untersmayr E, Ellinger A, Beil WJ, Jensen-Jarolim E. Eosinophils accumulate in the gastric mucosa of food-allergic mice. Int Arch Allergy Immunol. 2004;135:1–2. [PubMed] [Google Scholar]

140. Michael JG. The role of digestive enzymes in orally induced immune tolerance. Immunol Invest. 1989;18:1049–54. [PubMed] [Google Scholar]

141. Hogan SP, Mishra A, Brandt EB, Royalty MP, Pope SM, Zimmermann N, et al. A pathological function for eotaxin and eosinophils in eosinophilic gastrointestinal inflammation. Nat Immunol. 2001;2:353–60. [PubMed] [Google Scholar]

142. Barone KS, Reilly MR, Flanagan MP, Michael JG. Abrogation of oral tolerance by feeding encapsulated antigen. Cell Immunol. 2000;199:65–72. [PubMed] [Google Scholar]

143. Untersmayr E, Diesner SC, Bramswig KH, Knittelfelder R, Bakos N, Gundacker C, et al. Characterization of intrinsic and extrinsic risk factors for celery allergy in immunosenescence. Mech Ageing Dev. 2008;129:120–8. [PubMed] [Google Scholar]

144. Schöll I, Ackermann U, Ozdemir C, Blumer N, Dicke T, Sel S, et al. Anti-ulcer treatment during pregnancy induces food allergy in mouse mothers and a Th2-bias in their offspring. FASEB J. 2007;21:1264–70. [PMC free article] [PubMed] [Google Scholar]

145. Jensen-Jarolim E, Untersmayr E. Food safety: in vitro digestion tests are non-predictive for allergenic potential of food in stomach insufficiency. Immunol Lett. 2006;102:118–9. [PubMed] [Google Scholar]

146. Jensen-Jarolim E, Untersmayr E. In vitro tests for the determination of allergenic potency of “novel foods” and genetically modified organisms: relevance in vivo? Wien Klin Wochenschr. 2005;117:437–9. [PubMed] [Google Scholar]

147. Taylor SL, Hefle SL, Bindslev-Jensen C, Atkins FM, Andre C, Bruijnzeel-Koomen C, et al. A consensus protocol for the determination of the threshold doses for allergenic foods: how much is too much? Clin Exp Allergy. 2004;34:689–95. [PubMed] [Google Scholar]

148. Carreno I. The new European Community rules on the labeling of allergen ingredients in foodstuffs. Food Drug Law J. 2005;60:375–91. [PubMed] [Google Scholar]

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Drug action mechanisms of acid-suppression medication