Our circadian rhythm affects cholesterol levels, so it’s important to ask your provider when to take statins—morning or night? Show
Benefits of statins | When to take statins | Side effects | Best practices for taking statins Statins are a drug class that are considered by many experts to be the best medications for preventing, treating, and lowering a person’s risk of heart disease. If heart attacks, strokes, or peripheral artery blockages have been a problem already or are a future concern of yours, statins have a lot to offer. RELATED: Signs of heart problems worth worrying about Benefits of statinsBesides their well-known ability to lower cholesterol, statins stabilize cholesterol plaques, reduce inflammation in the circulatory system, promote blood vessel dilation, and reduce blood clotting factors. Having this myriad of mechanisms in your corner is of obvious importance if you have already experienced a heart attack or stroke or have been identified as having a blockage in an artery. If not, you could still stand to benefit if you have an increased risk of developing one of these issues. Your healthcare provider can help you to quantify your risk. By assessing your cholesterol blood tests, measuring to see if you have high blood pressure, and considering whether you smoke, have diabetes, or have a family history of cardiovascular disease, a healthcare professional can determine if taking a statin is worthwhile for you. If a statin is prescribed, the next step is to maximize its effectiveness and minimize the risk of adverse effects. Goals are based on sufficiently lowering the value of your low-density lipoprotein cholesterol or LDL cholesterol (high blood cholesterol), commonly referred to as bad cholesterol. This article will provide actionable steps to do so, focusing on what time of day to take a statin RELATED: High triglyceride treatment options When to take statinsOur body’s internal functions differ depending on the time of day. The circadian rhythm, or 24-hour cycle of bodily mechanisms, may affect blood cholesterol levels. Production of cholesterol peaks overnight. HMG-CoA reductase is an enzyme involved in the bodily synthesis of cholesterol, and statins are HMG-CoA reductase inhibitors. To maximize your benefit from the statin and lower lipid numbers the most, you will want to block the overnight synthesis of cholesterol. Accordingly, statins with short half-lives (remain active in the body for less time) should be taken in the evenings, while statins with long half-lives can generally be taken at any time. Which statins need to be taken in the morning?The only instance when a statin must be taken in the morning is when a twice-daily dosing regimen is in use. In these cases, morning and evening doses are taken. This is not a common practice, because many once-daily statin options are available. The following statins can be taken once or twice a day and should include a morning dose if taken twice daily. Lovastatin has another important facet; it should be taken with food for maximal absorption. Which statins need to be taken at night?Statins with short half-lives need to be taken at night to best blunt the nocturnal spike in cholesterol production. These drugs have an average half-life of around two hours, meaning that most of the medication is eliminated or rendered inactive within 10 hours. If taken early in the day, they will miss the overnight cholesterol surge. Statins you can take at any timeWithin the statin drug class, three members have relatively long half-lives. This characteristic allows them to be taken at any time of day. They tend to be more potent as well.
RELATED: Lipitor dosage, forms, and strengths Side effects are a common concern related to statins. The drug class is so commonly used, that you may know several people who take a statin and perhaps some who have had a side effect. Although there are some differences, the list of common adverse effects is consistent across the statin category:
A pre-existing concern about adverse effects, particularly muscle aches, could contribute to a higher incidence of reported symptoms from statins. If you expect a side effect, you may be more likely to think you are experiencing one. When participants were not informed as to whether they were taking the active drug or a placebo (inactive pill), one large study of the potent statin atorvastatin showed no difference in muscle side effects. Those who do have an adverse effect from a statin may be able to tolerate a lower dose or an alternative member of the drug class. RELATED: Lipitor side effects Deciding to stop a statin should be a mutual determination between you and your healthcare provider. The experience or fear of common or serious side effects can be a motivating factor for discontinuation, but there are consequences that should be considered. Those who stop and remain off statins due to intolerance have been shown to have a higher rate of heart attack and coronary artery disease. Accordingly, it is imperative to know the adverse effects of these drugs and recognize that these ill effects are not prevalent. RELATED: Lipitor (atorvastatin) alternatives
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