The NFL’s schedule release is Thursday night, but that isn’t going to stop us from tracking all the rumors (and confirming some where we can). We know the Buffalo Bills play on Monday night in Week 2, but the rest is still a bit mysterious.
Below, you’ll find the Home and Away opponents, plus each week will be listed out along with information relevant to the Bills’ potential opponent and rumors. The table at the bottom is only for confirmed games from a source we trust.
Let’s get after it!
Bills’ 2022 Opponents
Home Games
Away Games
Week-by-week Info
Week 1
Official: The Bills and Rams will tangle on the NFL’s opening night!
- We are reporting per sources that this game is “most likely” to be the Bills vs Los Angeles Rams on the NFL’s Opening Night broadcast, Thursday, September 8th.
- Not the Lions, per Philadelphia Inquirer
- Dolphins at Bills, per Dov Kleiman
Week 2 - OFFICIALLY ANNOUNCED
- Monday, Sept 19, 7:15 PM Eastern vs. Tennessee Titans (Full Story)
Week 3
The Bills will play at the Miami Dolphins at 1:00 PM Eastern, per sources.
Week 4
The Bills will play at the Baltimore Ravens at 1:00 PM, per sources.
- Not the Packers (via The Athletic, Boston Herald)
- Not the Patriots (via The Athletic, Boston Herald)
- Officially not the Chiefs (vs. TB)
Week 5
The Bills will host the Pittsburgh Steelers at 1:00 PM Eastern, per multiple sources
- Officially not the Packers (vs. NYG)
- Not the Patriots (per NBC Boston, Boston Herald)
- Not the Lions (per NBC Boston, Boston Herald)
- Not the Chiefs (via 670 Radio Chicago)
Week 6
The Bills will play at the Kansas City Chiefs in a nationally televised late afternoon game, per sources.
- Not the Packers (via The Athletic)
- Not the Jets (via The Athletic)- Not the Bears (via 670 radio Chicago)
- Bills vs Chiefs (via 670 Radio Chicago)
Week 7
The Bills are on their bye this week, per multiple sources.
- Not the Patriots (per NBC Boston and 670 Radio Chicago and Boston Herald)
- Not the Bears (per NBC Boston and 670 Radio Chicago and Boston Herald)
Week 8
The Bills will host the Green Bay Packers on Sunday Night Football, per sources.
- Not the Bears (via 670 Radio Chicago)
Week 9
The Bills will be in New Jersey to face the Jets in Week 9, per sources.
- Not the Bears (via 670 Radio Chicago)
Week 10
The Bills host the Minnesota Vikings in Week 10 at 1:00 PM Eastern, per sources.
- Officially not the Packers (vs. DAL)
Week 11
The Cleveland Browns come to town for an AFC showdown at 1:00 PM Eastern, per sources.
- Not the Packers (via The Athletic)
Week 12
The Bills and the Lions will kick off Thanksgiving day at 12:30 PM Eastern, per sources.
- Persistent but unconfirmed rumors have the Bills on Thanksgiving against the Baltimore Ravens or Detroit Lions.
Week 13
The Bills and Patriots will play the week after Thanksgiving on Thursday night, per multiple sources.
Week 14
The Jets visit Orchard Park on December 11th for a 1:00 PM kickoff, per sources.
- Not the Chiefs (via 670 Radio Chicago)
Week 15
The date and time are unknown due to the flexible scheduling, but the Bills will welcome the Dolphins in December, per sources. It could be either Saturday or Sunday.
- Not the Packers (via The Athletic)
- Not the Rams (via The Athletic)
Week 16
The Bills will head to Chicago to face the Bears on Christmas Eve, per multiple sources.
- Officially not the Rams (vs. DEN)
- Not the Packers (via The Athletic)
- Not the Dolphins (via The Athletic)
Week 17
The Bills are on Monday Night Football for their fifth prime-time contest when they face the Cincinnati Bengals in Week 17, per sources.
- Not the Packers (via The Athletic)
- Not the Vikings (via The Athletic)
Week 18
Buffalo finishes the season against the New England Patriots, per sources.
- Typically an AFC East opponent
- Not the Packers (via The Athletic)
- Not the Lions (via The Athletic)
Pre-1 | Saturday | Aug 13 | 4:00 PM ET | INDIANAPOLIS COLTS | It's been 30 years since Colts HC Frank Reich led the Bills to the Greatest Comeback in NFL History |
Pre-2 | Saturday | Aug 20 | 1:00 PM ET | DENVER BRONCOS | How much will Russell Wilson play? |
Pre-3 | Friday | Aug 26 | 7:00 PM ET | @ Carolina Panthers | Lots of connections still exist between the two franchises |
1 | Thursday | Sep 8 | 8:30 PM ET | @ Los Angeles Rams | NFL's Opening Night Game! Von Miller returns to L.A. |
2 | Monday | Sep 19 | 7:15 PM ET | TENNESSEE TITANS | Fifth straight season playing Tennesse, but first time in Buffalo since 2018 |
3 | Sunday | Sep 25 | 1:00 PM ET | @ Miami Dolphins | Bills have won seven straight vs Miami |
4 | Sunday | Oct 2 | 1:00 PM ET | @ Baltimore Ravens | Ravens play four straight vs AFC East to open 2022, last faced each other in 2020 AFC Playoffs |
5 | Sunday | Oct 9 | 1:00 PM ET | PITTSBURGH STEELERS | Lost to Pittsburgh to open the 2021 season, could see former Bills QB Mitch Trubisky under center |
6 | Sunday | Oct 16 | 4:25 PM ET | @ Kansas City Chiefs | National TV game, Bills fell to KC in AFC Divisional Round last season |
7 | BYE | Earliest bye in AFC East | |||
8 | Sunday | Oct 30 | 8:20 PM ET | GREEN BAY PACKERS | Aaron Rodgers beat Josh Allen for MVP in 2020 and 2021, Allen shut out in first start vs GB during rookie season |
9 | Sunday | Nov 4 | 1:00 PM ET | @ New York Jets | Last meaningful loss to Jets was in Josh Allen's rookie season, but Jets won in final week of 2019 when Bills clinched playoff seeding |
10 | Sunday | Nov 13 | 1:00 PM ET | MINNESOTA VIKINGS | Stefon Diggs was traded to the Bills by Minnesota in 2020 |
11 | Sunday | Nov 20 | 1:00 PM ET | CLEVELAND BROWNS | Most people think DeShaun Watson will be available for this game despite pending litigation for sexual assault |
12 | Thursday | Nov 24 | 12:30 PM ET | @ Detroit Lions | Bills are playing on Thanksgiving in 3 of past 4 seasons, they are currently 2-0 in those contests |
13 | Thursday | Dec 1 | 8:15 PM ET | @ New England Patriots | Bills didn't punt, turn over the ball, or kick a field goal in their last game against NE -- only touchdowns, game on Amazon Prime |
14 | Sunday | Dec 11 | 1:00 PM ET | NEW YORK JETS | Jets QB Zach Wilson was 7-of-20 for 87 yards, while taking 8 sacks, vs BUF in 2021 |
15 | Sat/Sun | Dec 17/18 | Flex | MIAMI DOLPHINS | Game day and time TBD due to NFL Flex, last December home loss to Miami was 2016 |
16 | Saturday | Dec 24 | 1:00 PM ET | @ Chicago Bears | Former Bills starting QB Nathan Peterman signed in Chicago this week |
17 | Monday | Jan 2 | 8:30 PM ET | @ Cincinnati Bengals | Bengals were the AFC rep in Super Bowl last year |
18 | Sat/Sun | Jan 7-8 | Flex | NEW ENGLAND PATRIOTS | Game day and time TBD due to NFL Flex, but Week 17 MNF means Saturday is less likely |
WC | TBD | Jan 14-16 | TBD | TBD | |
Div | TBD | Jan 21-22 | TBD | TBD | |
AFC | TBD | Jan 29 | TBD | TBD | |
SB | Sunday | Feb 12 | 6:30 PM | TBD | It's on FOX and from Glendale, Arizona |
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