What is a major disadvantage of using over the counter (OTC medications)

The guidelines for choosing and using OTC drugs are as follows:

  • Make sure that the self-diagnosis is as accurate as possible. Do not assume the problem is “something that is going around.”

  • Choose a product because the ingredients are appropriate for the condition, not because the product has a familiar brand name.

  • Choose a product with the fewest appropriate ingredients. Products that attempt to relieve every possible symptom are likely to expose people to unnecessary drugs, pose additional risks, and cost more.

  • Read the label carefully to determine the correct dose and precautions, including what conditions would make the drug a poor choice.

  • When in doubt, ask a pharmacist or doctor what the most appropriate ingredient or product is.

  • Ask a pharmacist to check for potential interactions with other drugs being used.

  • Ask a pharmacist to identify possible side effects.

  • Do not take more than the recommended dose.

  • Do not take an over-the-counter drug longer than the maximum time suggested on the label. Stop taking the drug if symptoms worsen.

  • Keep all drugs, including over-the-counter drugs, out of the reach of children.

Dinulos JGH. Atopic dermatitis. In: Dinulos JGH, ed. Habif's Clinical Dermatology: A Color Guide in Diagnosis and Therapy. 7th ed. Philadelphia, PA: Elsevier; 2021:chap 5.

Garza I, Robertson CE, Smith JH, Whealy MA. Headache and other craniofacial pain. In: Jankovic J, Mazziotta JC, Pomeroy SL, Newman NJ, eds. Bradley and Daroff's Neurology in Clinical Practice. 8th ed. Philadelphia, PA: Elsevier Saunders; 2022:chap 102.

Mazer-Amirshahi M, Wilson MD. Drug therapy for the pediatric patient. In: Walls RM, Hockberger RS, Gausche-Hill M, eds. Rosen's Emergency Medicine: Concepts and Clinical Practice. 9th ed. Philadelphia, PA: Elsevier; 2018:chap 176.

Semrad CE. Approach to the patient with diarrhea and malabsorption. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 26th ed. Philadelphia, PA: Elsevier; 2020:chap 131.


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A simple rash is called dermatitis, meaning inflammation of the skin. Contact dermatitis is caused by things your skin touches, such as:

  • Chemicals in elastic, latex, and rubber products
  • Cosmetics, soaps, and detergents
  • Dyes and other chemicals in clothing
  • Poison ivy, oak, or sumac

Seborrheic dermatitis is a rash that appears in patches of redness and scaling around the eyebrows, eyelids, mouth, nose, trunk, and behind the ears. If it happens on your scalp, it is called dandruff in adults and cradle cap in infants.

Age, stress, fatigue, weather extremes, oily skin, infrequent shampooing, and alcohol-based lotions aggravate this harmless but bothersome condition.

Other common causes of a rash include:

  • Eczema (atopic dermatitis) -- Tends to happen in people with allergies or asthma. The rash is generally red, itchy, and scaly.
  • Psoriasis -- Tends to occur as red, scaly, patches over joints and along the scalp. It is sometimes itchy. Fingernails may also be affected.
  • Impetigo -- Common in children, this infection is from bacteria that live in the top layers of the skin. It appears as red sores that turn into blisters, ooze, then for a honey colored crust over.
  • Shingles -- A painful blistered skin condition caused by the same virus as chickenpox. The virus can lie dormant in your body for many years and re-emerge as shingles. It usually affects only one side of the body.
  • Childhood illnesses such as chickenpox, measles, roseola, rubella, hand-foot-mouth disease, fifth disease, and scarlet fever.
  • Medicines and insect bites or stings.

Many medical conditions can cause a rash as well. These include:


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Dinulos JGH. Dermatologic surgical procedures. In: Dinulos JGH, ed. Habif's Clinical Dermatology: A Color Guide to Diagnosis and Therapy. 7th ed. Philadelphia, PA: Elsevier; 2021:chap 27.

High WA, Tomasini CF, Argenziano G, Zalaudek I. Basic principles of dermatology. In: Bolognia JL, Schaffer JV, Cerroni L, eds. Dermatology. 4th ed. Philadelphia, PA: Elsevier; 2018:chap 0.

Pfenninger JL. Skin biopsy. In: Fowler GC, eds. Pfenninger and Fowler's Procedures for Primary Care. 4th ed. Philadelphia, PA: Elsevier; 2020:chap 26.


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Gailani D, Wheeler AP, Neff AT. Rare coagulation factor deficiencies. In: Hoffman R, Benz EJ, Silberstein LE, et al, eds. Hematology: Basic Principles and Practice. 7th ed. Philadelphia, PA: Elsevier; 2018:chap 137.

Hall JE, Hall ME. Hemostasis and blood coagulation. In: Hall JE, Hall ME, eds. Guyton and Hall Textbook of Medical Physiology. 14th ed. Philadelphia, PA: Elsevier; 2021:chap 37.

Neff AT. Von Willebrand disease and hemorrhagic abnormalities of platelet and vascular function. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 26th ed. Philadelphia, PA: Elsevier; 2020:chap 164.


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Bhatt MD, Ho K, Chan AKC. Disorders of coagulation in the neonate. In: Hoffman R, Benz EJ, Silberstein LE, et al, eds. Hematology: Basic Principles and Practice. 7th ed. Philadelphia, PA: Elsevier; 2018:chap 150.

Neff AT. Von Willebrand disease and hemorrhagic abnormalities of platelet and vascular function. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 26th ed. Philadelphia, PA: Elsevier; 2020:chap 164.


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Chernecky CC, Berger BJ. Prothrombin time (PT) and international normalized ratio (INR) - blood. In: Chernecky CC, Berger BJ, eds. Laboratory Tests and Diagnostic Procedures. 6th ed. St Louis, MO: Elsevier Saunders; 2013:930-935.

Lee GM, Ortel TL. Antithrombotic therapy. In: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis and Management by Laboratory Methods. 24th ed. Philadelphia, PA: Elsevier; 2022:chap 43.

Schafer AI. Approach to the patient with bleeding and thrombosis. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 26th ed. Philadelphia, PA: Elsevier; 2020:chap 162.


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Blood is made up of two parts:

  • Fluid (plasma or serum)
  • Cells

Plasma is the fluid part of the blood in the bloodstream that contains substances such as glucose, electrolytes, proteins, and water. Serum is the fluid part that remains after the blood is allowed to clot in a test tube.

Cells in the blood include red blood cells, white blood cells, and platelets.

Blood helps move oxygen, nutrients, waste products, and other materials through the body. It helps control body temperature, fluid balance, and the body's acid-base balance.

Tests on blood or parts of blood may give your provider important clues about your health.

URL of this page: https://medlineplus.gov/overthecountermedicines.html

Also called: Non-prescription drugs, OTC medicines

Over-the-counter (OTC) medicines are drugs you can buy without a prescription. Some OTC medicines relieve aches, pains, and itches. Some prevent or cure diseases, like tooth decay and athlete's foot. Others help manage recurring problems, like migraines and allergies.

In the United States, the Food and Drug Administration decides whether a medicine is safe and effective enough to sell over-the-counter. This allows you to take a more active role in your health care. But you also need to be careful to avoid mistakes. Make sure to follow the instructions on the drug label. If you don't understand the instructions, ask your pharmacist or health care provider.

Also keep in mind that that there are still risks to taking OTC medicines:

  • The medicine you are taking could interact with other medicines, supplements, foods, or drinks
  • Some medicines are not right for people with certain medical conditions. For example, people with high blood pressure should not take certain decongestants.
  • Some people are allergic to certain medicines
  • Many medicines are not safe during pregnancy. If you are pregnant, check with your health care provider before taking any medicine.
  • Be careful when giving medicines to children. Make sure that you give your child the correct dose. If you are giving your child a liquid medicine, don't use a kitchen spoon. Instead use a measuring spoon or a dosing cup marked in teaspoons.

If you have been taking an OTC medicine but your symptoms don't go away, contact your health care provider. You should not take OTC medicines longer or in higher doses than the label recommends.

Food and Drug Administration

  • What Is Pharmacogenomics?
    What is a major disadvantage of using over the counter (OTC medications)
    (National Institute of General Medical Sciences)

The information on this site should not be used as a substitute for professional medical care or advice. Contact a health care provider if you have questions about your health.

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