Hydroxyzine oral tablets can cause mild or serious side effects. The following lists contain some of the key side effects that may occur while taking hydroxyzine oral tablets. These lists do not include all possible side effects.
For more information about the possible side effects of hydroxyzine oral tablets, talk with your doctor or pharmacist. They can give you tips on how to deal with any side effects that may be concerning or bothersome.
Side effects in women who take hydroxyzine are the same as those that occur in men.*
Note: The Food and Drug Administration (FDA) tracks side effects of drugs it has approved. If you would like to notify the FDA about a side effect you’ve had with hydroxyzine oral tablets, you can do so through MedWatch.
* Sex and gender exist on spectrums. Use of the terms “women” and “men” in this article refers to sex assigned at birth.
Mild side effects
Mild side effects* of hydroxyzine oral tablets can include:
Most of these side effects may go away within a few days or a couple of weeks. But if they become more severe or don’t go away, talk with your doctor or pharmacist.
* This is a partial list of mild side effects from hydroxyzine oral tablets. To learn about other mild side effects, talk with your doctor or pharmacist or view the prescribing information for hydroxyzine oral tablets.
† For more information about this side effect, see “Side effect details” below.
Serious side effects
Serious side effects from hydroxyzine oral tablets aren’t common, but they can occur. Call your doctor right away if you have serious side effects. Call 911 or your local emergency number if your symptoms feel life threatening or if you think you’re having a medical emergency.
Serious side effects and their symptoms can include:
* For more information about this side effect, see “Side effect details” below.
Side effects in children
Children may be more likely to have convulsions as a side effect from taking hydroxyzine.
However, it’s important to note that this side effect wasn’t reported in clinical trials of hydroxyzine. These reports came after the drug was approved. Since these reports happened outside of clinical trials, it’s not clear if hydroxyzine caused the side effect. Other factors could also cause convulsions in people taking hydroxyzine oral tablets.
In addition, children may be more likely to have other side effects from hydroxyzine, such as:
- confusion or being unable to concentrate
- sleepiness
- fatigue (lack of energy)
- weakness
It’s very important that your child takes the exact dose of hydroxyzine prescribed for them. This helps minimize their risk for side effects.
If you have additional questions about hydroxyzine side effects in children, talk with your doctor or pharmacist.
Side effect details
Here’s some detail on certain side effects this drug may cause.
Sleepiness
Sleepiness is a possible side effect from taking hydroxyzine oral tablets. The side effect was commonly reported by people taking the drug in clinical trials. This isn’t unexpected, based on how the drug works. (For more information, see the “How hydroxyzine oral tablet works” section below.)
When you first start taking hydroxyzine, you should avoid driving a car or operating machinery until you know how the drug will affect you. You should also avoid consuming alcohol and using other medications that can cause sleepiness.
If you’re taking hydroxyzine and have sleepiness that is bothersome to you, talk with your doctor or pharmacist. They may be able to suggest ways to improve your energy levels. They may also suggest that you stop taking hydroxyzine and try other treatments for your condition.
Low blood pressure
Based on how hydroxyzine works, you may have low blood pressure as a side effect of taking this drug. (For more information, see the “How hydroxyzine oral tablet works” section below.)
Low blood pressure wasn’t reported by people taking hydroxyzine in clinical trials. But it has been reported since hydroxyzine was approved by the FDA.
Some people may not have symptoms when they have low blood pressure, but others might. Symptoms can include:
- dizziness
- nausea
- being unable to concentrate
Some of these symptoms are also potential side effects of hydroxyzine. So it may be hard to tell if you have a mild case of low blood pressure.
If your blood pressure becomes dangerously low, you may have symptoms such as:
- blurry vision
- cold, clammy skin
- fainting
- rapid, shallow breathing
If you’re having symptoms of low blood pressure while taking hydroxyzine, contact your doctor as soon as you can. They’ll let you know whether you need medical attention. They can also help determine whether hydroxyzine or other factors could be causing this side effect.
Depending on the cause of your low blood pressure, your doctor may recommend ways to treat this side effect. They may also suggest that you stop taking hydroxyzine and try a different medication to treat your condition.
Fatigue
You may experience fatigue (lack of energy) while taking hydroxyzine. This side effect was commonly reported by people who took the medication in clinical trials.
With fatigue, you feel a noticeable lack of energy. This happens despite getting enough sleep and eating the right number of calories for you.
Based on how hydroxyzine oral tablets work, this side effect isn’t unexpected. (For more information, see the “How hydroxyzine oral tablet works” section below.)
Healthcare professionals are used to seeing this side effect from hydroxyzine. So you should talk with your doctor or pharmacist if you’re having fatigue while taking this drug. Even if your fatigue is mild, they may be able to suggest ways to improve your energy levels.
If the fatigue doesn’t go away or is bothering you, your doctor may suggest that you stop taking hydroxyzine and try other treatments for your condition.
Allergic reactionAs with most drugs, some people can have an allergic reaction after taking hydroxyzine oral tablets.
Symptoms of a mild allergic reaction can include:
- skin rash
- itchiness
- flushing (temporary warmth, redness, or deepening of skin color)
A more severe allergic reaction is rare but possible. Symptoms of a severe allergic reaction can include:
- swelling under your skin, typically in your eyelids, lips, hands, or feet
- swelling of your tongue, mouth, or throat
- trouble breathing
Call your doctor right away if you have an allergic reaction to hydroxyzine oral tablets, as the reaction could become severe. Call 911 or your local emergency number if your symptoms feel life threatening or if you think you’re having a medical emergency.
No Interactions Found
Interactions Found
Contraindicated
Serious - Use Alternative
Significant - Monitor Closely
Minor
All Interactions Sort By: SeverityName
Contraindicated (2)
- dronedarone
hydroxyzine and dronedarone both increase QTc interval. Contraindicated.
- thioridazine
hydroxyzine and thioridazine both increase QTc interval. Contraindicated.
Serious - Use Alternative (72)
- amiodarone
hydroxyzine increases toxicity of amiodarone by QTc interval. Avoid or Use Alternate Drug. Increases risk of torsades de pointes.
- amisulpride
amisulpride and hydroxyzine both increase QTc interval. Avoid or Use Alternate Drug. ECG monitoring is recommended if coadministered.
- anagrelide
hydroxyzine and anagrelide both increase QTc interval. Avoid or Use Alternate Drug.
- arsenic trioxide
hydroxyzine and arsenic trioxide both increase QTc interval. Avoid or Use Alternate Drug.
- artemether
artemether and hydroxyzine both increase QTc interval. Avoid or Use Alternate Drug.
- artemether/lumefantrine
artemether/lumefantrine and hydroxyzine both increase QTc interval. Avoid or Use Alternate Drug.
- asenapine
hydroxyzine and asenapine both increase QTc interval. Avoid or Use Alternate Drug.
- bedaquiline
bedaquiline and hydroxyzine both increase QTc interval. Avoid or Use Alternate Drug.
- calcium/magnesium/potassium/sodium oxybates
hydroxyzine, calcium/magnesium/potassium/sodium oxybates. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.
- ceritinib
ceritinib and hydroxyzine both increase QTc interval. Avoid or Use Alternate Drug.
- chloroquine
chloroquine and hydroxyzine both increase QTc interval. Avoid or Use Alternate Drug.
- citalopram
hydroxyzine increases toxicity of citalopram by QTc interval. Avoid or Use Alternate Drug. Increases risk of torsades de pointes.
- clozapine
hydroxyzine increases toxicity of clozapine by QTc interval. Avoid or Use Alternate Drug. Increases risk of torsades de pointes.
- crizotinib
crizotinib and hydroxyzine both increase QTc interval. Avoid or Use Alternate Drug.
- desflurane
desflurane and hydroxyzine both increase QTc interval. Avoid or Use Alternate Drug.
- disopyramide
hydroxyzine and disopyramide both increase QTc interval. Avoid or Use Alternate Drug.
- dofetilide
hydroxyzine and dofetilide both increase QTc interval. Avoid or Use Alternate Drug.
- droperidol
hydroxyzine increases toxicity of droperidol by QTc interval. Avoid or Use Alternate Drug. Increases risk of torsades de pointes.
- eluxadoline
hydroxyzine, eluxadoline. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid coadministration with other drugs that cause constipation. Increases risk for constipation related serious adverse reactions.
- encorafenib
encorafenib and hydroxyzine both increase QTc interval. Avoid or Use Alternate Drug.
- entrectinib
entrectinib and hydroxyzine both increase QTc interval. Avoid or Use Alternate Drug.
- eribulin
eribulin and hydroxyzine both increase QTc interval. Avoid or Use Alternate Drug.
- fexinidazole
fexinidazole and hydroxyzine both increase QTc interval. Avoid or Use Alternate Drug. Avoid coadministration of fexinidazole with drugs known to block potassium channels or prolong QT interval.
- flecainide
hydroxyzine and flecainide both increase QTc interval. Avoid or Use Alternate Drug.
- fluoxetine
hydroxyzine increases toxicity of fluoxetine by QTc interval. Avoid or Use Alternate Drug. Increases risk of torsades de pointes.
- foscarnet
hydroxyzine and foscarnet both increase QTc interval. Avoid or Use Alternate Drug.
- glasdegib
hydroxyzine and glasdegib both increase QTc interval. Avoid or Use Alternate Drug.
- hydroxychloroquine sulfate
hydroxyzine and hydroxychloroquine sulfate both increase QTc interval. Avoid or Use Alternate Drug.
- ibutilide
hydroxyzine and ibutilide both increase QTc interval. Avoid or Use Alternate Drug.
- iloperidone
hydroxyzine increases toxicity of iloperidone by QTc interval. Avoid or Use Alternate Drug. Increases risk of torsades de pointes.
- isocarboxazid
isocarboxazid increases effects of hydroxyzine by Other (see comment). Avoid or Use Alternate Drug. Comment: Isocarboxazid should not be administered in combination with antihistamines because of potential additive CNS depressant effects. MAO inhibitors also prolong and intensify anticholinergic effects of antihistamines. .
- isoflurane
hydroxyzine and isoflurane both increase QTc interval. Avoid or Use Alternate Drug.
- lefamulin
lefamulin and hydroxyzine both increase QTc interval. Avoid or Use Alternate Drug.
- lenvatinib
hydroxyzine and lenvatinib both increase QTc interval. Avoid or Use Alternate Drug.
- lofexidine
hydroxyzine and lofexidine both increase QTc interval. Avoid or Use Alternate Drug.
- lopinavir
hydroxyzine and lopinavir both increase QTc interval. Avoid or Use Alternate Drug.
- macimorelin
hydroxyzine and macimorelin both increase QTc interval. Avoid or Use Alternate Drug.
- metoclopramide intranasal
hydroxyzine, metoclopramide intranasal. Either increases effects of the other by Other (see comment). Avoid or Use Alternate Drug. Comment: Avoid use of metoclopramide intranasal or interacting drug, depending on importance of drug to patient.
- midostaurin
hydroxyzine and midostaurin both increase QTc interval. Avoid or Use Alternate Drug.
- mifepristone
hydroxyzine and mifepristone both increase QTc interval. Avoid or Use Alternate Drug.
- mobocertinib
hydroxyzine and mobocertinib both increase QTc interval. Avoid or Use Alternate Drug.
- nilotinib
hydroxyzine and nilotinib both increase QTc interval. Avoid or Use Alternate Drug.
- osimertinib
hydroxyzine and osimertinib both increase QTc interval. Avoid or Use Alternate Drug.
- oxaliplatin
hydroxyzine and oxaliplatin both increase QTc interval. Avoid or Use Alternate Drug.
- ozanimod
hydroxyzine and ozanimod both increase QTc interval. Avoid or Use Alternate Drug.
- paliperidone
hydroxyzine and paliperidone both increase QTc interval. Avoid or Use Alternate Drug.
- panobinostat
hydroxyzine and panobinostat both increase QTc interval. Avoid or Use Alternate Drug.
- pazopanib
hydroxyzine and pazopanib both increase QTc interval. Avoid or Use Alternate Drug.
- pimavanserin
hydroxyzine and pimavanserin both increase QTc interval. Avoid or Use Alternate Drug.
- pimozide
hydroxyzine and pimozide both increase QTc interval. Contraindicated.
- pitolisant
hydroxyzine decreases effects of pitolisant by Other (see comment). Avoid or Use Alternate Drug. Comment: Pitolisant increases histamine levels in the brain; therefore, H1 receptor antagonists that cross the blood-brain barrier may reduce the efficacy of pitolisant.hydroxyzine and pitolisant both increase QTc interval. Avoid or Use Alternate Drug.
- ponesimod
hydroxyzine and ponesimod both increase QTc interval. Avoid or Use Alternate Drug.
- procainamide
hydroxyzine increases toxicity of procainamide by QTc interval. Avoid or Use Alternate Drug. Increases risk of torsades de pointes.
- propafenone
hydroxyzine and propafenone both increase QTc interval. Avoid or Use Alternate Drug.
- quetiapine
hydroxyzine increases toxicity of quetiapine by QTc interval. Avoid or Use Alternate Drug. Increases risk of torsades de pointes.
- quinidine
hydroxyzine increases toxicity of quinidine by QTc interval. Avoid or Use Alternate Drug. Increases risk of torsades de pointes.
- quinine
hydroxyzine and quinine both increase QTc interval. Avoid or Use Alternate Drug.
- ribociclib
hydroxyzine and ribociclib both increase QTc interval. Avoid or Use Alternate Drug.
- saquinavir
hydroxyzine and saquinavir both increase QTc interval. Avoid or Use Alternate Drug.
- selpercatinib
hydroxyzine and selpercatinib both increase QTc interval. Avoid or Use Alternate Drug.
- sevoflurane
hydroxyzine and sevoflurane both increase QTc interval. Avoid or Use Alternate Drug.
- siponimod
hydroxyzine and siponimod both increase QTc interval. Avoid or Use Alternate Drug.
- sodium oxybate
hydroxyzine, sodium oxybate. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.
- sorafenib
hydroxyzine and sorafenib both increase QTc interval. Avoid or Use Alternate Drug.
- sotalol
hydroxyzine increases toxicity of sotalol by QTc interval. Avoid or Use Alternate Drug. Increases risk of torsades de pointes.
- tetrabenazine
hydroxyzine and tetrabenazine both increase QTc interval. Avoid or Use Alternate Drug.
- toremifene
hydroxyzine and toremifene both increase QTc interval. Avoid or Use Alternate Drug.
- tranylcypromine
tranylcypromine increases effects of hydroxyzine by Other (see comment). Avoid or Use Alternate Drug. Comment: Tranylcypromine should not be administered in combination with antihistamines because of potential additive CNS depressant effects. MAO inhibitors also prolong and intensify anticholinergic effects of antihistamines.
- trazodone
hydroxyzine and trazodone both increase QTc interval. Avoid or Use Alternate Drug.
- vandetanib
hydroxyzine and vandetanib both increase QTc interval. Avoid or Use Alternate Drug.
- vemurafenib
hydroxyzine and vemurafenib both increase QTc interval. Avoid or Use Alternate Drug.
- ziprasidone
hydroxyzine increases toxicity of ziprasidone by QTc interval. Avoid or Use Alternate Drug. Increases risk of torsades de pointes.
Monitor Closely (260)
- albuterol
hydroxyzine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.albuterol and hydroxyzine both increase QTc interval. Use Caution/Monitor.
- alfentanil
hydroxyzine and alfentanil both increase sedation. Use Caution/Monitor.
- alfuzosin
alfuzosin and hydroxyzine both increase QTc interval. Use Caution/Monitor.
- alprazolam
hydroxyzine and alprazolam both increase sedation. Use Caution/Monitor.
- amifampridine
hydroxyzine increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.
- amitriptyline
hydroxyzine and amitriptyline both increase sedation. Use Caution/Monitor.hydroxyzine and amitriptyline both increase QTc interval. Use Caution/Monitor.
- amobarbital
hydroxyzine and amobarbital both increase sedation. Use Caution/Monitor.
- amoxapine
hydroxyzine and amoxapine both increase sedation. Use Caution/Monitor.
- apomorphine
hydroxyzine and apomorphine both increase sedation. Use Caution/Monitor.apomorphine and hydroxyzine both increase QTc interval. Use Caution/Monitor.
- arformoterol
hydroxyzine increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.arformoterol and hydroxyzine both increase QTc interval. Use Caution/Monitor.
- aripiprazole
hydroxyzine and aripiprazole both increase sedation. Use Caution/Monitor.aripiprazole and hydroxyzine both increase QTc interval. Use Caution/Monitor.
- armodafinil
hydroxyzine increases and armodafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- atomoxetine
atomoxetine and hydroxyzine both increase QTc interval. Use Caution/Monitor.
- azelastine
azelastine and hydroxyzine both increase sedation. Use Caution/Monitor.
- azithromycin
hydroxyzine increases toxicity of azithromycin by QTc interval. Use Caution/Monitor. Increases risk of torsades de pointes.
- baclofen
hydroxyzine and baclofen both increase sedation. Use Caution/Monitor.
- belladonna and opium
hydroxyzine and belladonna and opium both increase sedation. Use Caution/Monitor.
- benperidol
hydroxyzine and benperidol both increase sedation. Use Caution/Monitor.
- benzphetamine
hydroxyzine increases and benzphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- brexanolone
brexanolone, hydroxyzine. Either increases toxicity of the other by sedation. Use Caution/Monitor.
- brompheniramine
brompheniramine and hydroxyzine both increase sedation. Use Caution/Monitor.
- buprenorphine
hydroxyzine and buprenorphine both increase sedation. Use Caution/Monitor.hydroxyzine and buprenorphine both increase QTc interval. Modify Therapy/Monitor Closely. If coadministration necessary, consider consider dose reduction of one or both drugs due to potential for additive pharmacological effects
- buprenorphine buccal
hydroxyzine and buprenorphine buccal both increase sedation. Use Caution/Monitor.
- butabarbital
hydroxyzine and butabarbital both increase sedation. Use Caution/Monitor.
- butalbital
hydroxyzine and butalbital both increase sedation. Use Caution/Monitor.
- butorphanol
hydroxyzine and butorphanol both increase sedation. Use Caution/Monitor.
- caffeine
hydroxyzine increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- carbinoxamine
carbinoxamine and hydroxyzine both increase sedation. Use Caution/Monitor.
- carisoprodol
hydroxyzine and carisoprodol both increase sedation. Use Caution/Monitor.
- chloral hydrate
hydroxyzine and chloral hydrate both increase sedation. Use Caution/Monitor.
- chlordiazepoxide
hydroxyzine and chlordiazepoxide both increase sedation. Use Caution/Monitor.
- chlorpheniramine
chlorpheniramine and hydroxyzine both increase sedation. Use Caution/Monitor.
- chlorpromazine
hydroxyzine and chlorpromazine both increase sedation. Use Caution/Monitor.hydroxyzine increases toxicity of chlorpromazine by QTc interval. Use Caution/Monitor. Increases risk of torsades de pointes.
- chlorzoxazone
hydroxyzine and chlorzoxazone both increase sedation. Use Caution/Monitor.
- cinnarizine
cinnarizine and hydroxyzine both increase sedation. Use Caution/Monitor.
- ciprofloxacin
hydroxyzine and ciprofloxacin both increase QTc interval. Use Caution/Monitor.
- clarithromycin
hydroxyzine increases toxicity of clarithromycin by QTc interval. Use Caution/Monitor. Increases risk of torsades de pointes.
- clemastine
clemastine and hydroxyzine both increase sedation. Use Caution/Monitor.
- clobazam
hydroxyzine, clobazam. Other (see comment). Use Caution/Monitor. Comment: Concomitant administration can increase the potential for CNS effects (e.g., increased sedation or respiratory depression).
- clomipramine
hydroxyzine and clomipramine both increase sedation. Use Caution/Monitor.hydroxyzine and clomipramine both increase QTc interval. Use Caution/Monitor.
- clonazepam
hydroxyzine and clonazepam both increase sedation. Use Caution/Monitor.
- clonidine
clonidine, hydroxyzine. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration enhances CNS depressant effects.
- clorazepate
hydroxyzine and clorazepate both increase sedation. Use Caution/Monitor.
- clozapine
hydroxyzine and clozapine both increase sedation. Use Caution/Monitor.
- codeine
hydroxyzine and codeine both increase sedation. Use Caution/Monitor.
- cyclizine
cyclizine and hydroxyzine both increase sedation. Use Caution/Monitor.
- cyclobenzaprine
hydroxyzine and cyclobenzaprine both increase sedation. Use Caution/Monitor.
- cyproheptadine
cyproheptadine and hydroxyzine both increase sedation. Use Caution/Monitor.
- dantrolene
hydroxyzine and dantrolene both increase sedation. Use Caution/Monitor.
- daridorexant
hydroxyzine and daridorexant both increase sedation. Modify Therapy/Monitor Closely. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment.
- dasatinib
dasatinib and hydroxyzine both increase QTc interval. Use Caution/Monitor.
- degarelix
degarelix and hydroxyzine both increase QTc interval. Use Caution/Monitor.
- desflurane
desflurane and hydroxyzine both increase sedation. Use Caution/Monitor.
- desipramine
hydroxyzine and desipramine both increase sedation. Use Caution/Monitor.hydroxyzine and desipramine both increase QTc interval. Use Caution/Monitor.
- deutetrabenazine
hydroxyzine and deutetrabenazine both increase sedation. Use Caution/Monitor.deutetrabenazine and hydroxyzine both increase QTc interval. Use Caution/Monitor.
- dexchlorpheniramine
dexchlorpheniramine and hydroxyzine both increase sedation. Use Caution/Monitor.
- dexfenfluramine
hydroxyzine increases and dexfenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- dexmedetomidine
hydroxyzine and dexmedetomidine both increase sedation. Use Caution/Monitor.
- dexmethylphenidate
hydroxyzine increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- dextroamphetamine
hydroxyzine increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- dextromoramide
hydroxyzine and dextromoramide both increase sedation. Use Caution/Monitor.
- diamorphine
hydroxyzine and diamorphine both increase sedation. Use Caution/Monitor.
- diazepam
hydroxyzine and diazepam both increase sedation. Use Caution/Monitor.
- diazepam intranasal
diazepam intranasal, hydroxyzine. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration may potentiate the CNS-depressant effects of each drug.
- diethylpropion
hydroxyzine increases and diethylpropion decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- difelikefalin
difelikefalin and hydroxyzine both increase sedation. Use Caution/Monitor.
- difenoxin hcl
hydroxyzine and difenoxin hcl both increase sedation. Use Caution/Monitor.
- dimenhydrinate
dimenhydrinate and hydroxyzine both increase sedation. Use Caution/Monitor.
- diphenhydramine
diphenhydramine and hydroxyzine both increase sedation. Use Caution/Monitor.
- diphenoxylate hcl
hydroxyzine and diphenoxylate hcl both increase sedation. Use Caution/Monitor.
- dipipanone
hydroxyzine and dipipanone both increase sedation. Use Caution/Monitor.
- dobutamine
hydroxyzine increases and dobutamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- dolasetron
dolasetron and hydroxyzine both increase QTc interval. Use Caution/Monitor.
- donepezil
donepezil and hydroxyzine both increase QTc interval. Use Caution/Monitor.
- donepezil transdermal
donepezil transdermal, hydroxyzine. Either decreases effects of the other by pharmacodynamic antagonism. Use Caution/Monitor.
- dopamine
hydroxyzine increases and dopamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- dopexamine
hydroxyzine increases and dopexamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- dosulepin
hydroxyzine and dosulepin both increase sedation. Use Caution/Monitor.
- doxepin
hydroxyzine and doxepin both increase sedation. Use Caution/Monitor.doxepin and hydroxyzine both increase QTc interval. Use Caution/Monitor.
- doxylamine
hydroxyzine and doxylamine both increase sedation. Use Caution/Monitor.
- droperidol
hydroxyzine and droperidol both increase sedation. Use Caution/Monitor.
- efavirenz
efavirenz and hydroxyzine both increase QTc interval. Use Caution/Monitor.
- eliglustat
hydroxyzine and eliglustat both increase QTc interval. Use Caution/Monitor.
- ephedrine
hydroxyzine increases and ephedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- epinephrine
hydroxyzine increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- epinephrine racemic
hydroxyzine increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- erythromycin base
hydroxyzine increases toxicity of erythromycin base by QTc interval. Use Caution/Monitor. Increases risk of torsades de pointes.
- erythromycin ethylsuccinate
hydroxyzine increases toxicity of erythromycin ethylsuccinate by QTc interval. Use Caution/Monitor. Increases risk of torsades de pointes.
- erythromycin lactobionate
hydroxyzine increases toxicity of erythromycin lactobionate by QTc interval. Use Caution/Monitor. Increases risk of torsades de pointes.
- erythromycin stearate
hydroxyzine increases toxicity of erythromycin stearate by QTc interval. Use Caution/Monitor. Increases risk of torsades de pointes.
- escitalopram
hydroxyzine and escitalopram both increase QTc interval. Use Caution/Monitor.
- esketamine intranasal
esketamine intranasal, hydroxyzine. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.
- estazolam
hydroxyzine and estazolam both increase sedation. Use Caution/Monitor.
- ethanol
hydroxyzine and ethanol both increase sedation. Use Caution/Monitor.
- etomidate
etomidate and hydroxyzine both increase sedation. Use Caution/Monitor.
- ezogabine
hydroxyzine and ezogabine both increase QTc interval. Use Caution/Monitor. Slight and transient QT-prolongation observed, particularly when dose titrated to 1200mg/day. QT interval should be monitored when ezogabine is prescribed with agents known to increase QT interval.
- fenfluramine
hydroxyzine increases and fenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- fentanyl
fentanyl, hydroxyzine. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of fentanyl with anticholinergics may increase risk for urinary retention and/or severe constipation, which may lead to paralytic ileus.
- fentanyl intranasal
fentanyl intranasal, hydroxyzine. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of fentanyl with anticholinergics may increase risk for urinary retention and/or severe constipation, which may lead to paralytic ileus.
- fentanyl transdermal
fentanyl transdermal, hydroxyzine. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of fentanyl with anticholinergics may increase risk for urinary retention and/or severe constipation, which may lead to paralytic ileus.
- fentanyl transmucosal
fentanyl transmucosal, hydroxyzine. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of fentanyl with anticholinergics may increase risk for urinary retention and/or severe constipation, which may lead to paralytic ileus.
- fingolimod
fingolimod and hydroxyzine both increase QTc interval. Use Caution/Monitor.
- flibanserin
hydroxyzine and flibanserin both increase sedation. Modify Therapy/Monitor Closely. Risk for sedation increased if flibanserin is coadministration with other CNS depressants.
- fluconazole
hydroxyzine and fluconazole both increase QTc interval. Use Caution/Monitor.
- fluphenazine
hydroxyzine and fluphenazine both increase sedation. Use Caution/Monitor.hydroxyzine and fluphenazine both increase QTc interval. Use Caution/Monitor.
- flurazepam
hydroxyzine and flurazepam both increase sedation. Use Caution/Monitor.
- fluvoxamine
hydroxyzine and fluvoxamine both increase QTc interval. Use Caution/Monitor.
- formoterol
hydroxyzine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- fostemsavir
hydroxyzine and fostemsavir both increase QTc interval. Use Caution/Monitor. QTc prolongation reported with higher than recommended doses of fostemsavir.
- gabapentin
gabapentin, hydroxyzine. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.
- gabapentin enacarbil
gabapentin enacarbil, hydroxyzine. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.
- ganaxolone
hydroxyzine and ganaxolone both increase sedation. Use Caution/Monitor.
- gemifloxacin
gemifloxacin and hydroxyzine both increase QTc interval. Use Caution/Monitor.
- gemtuzumab
hydroxyzine and gemtuzumab both increase QTc interval. Use Caution/Monitor.
- gilteritinib
gilteritinib and hydroxyzine both increase QTc interval. Use Caution/Monitor.
- glycopyrronium tosylate topical
glycopyrronium tosylate topical, hydroxyzine. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration of glycopyrronium tosylate topical with other anticholinergic medications may result in additive anticholinergic adverse effects.
- goserelin
hydroxyzine and goserelin both increase QTc interval. Use Caution/Monitor.
- gotu kola
gotu kola increases effects of hydroxyzine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.
- granisetron
granisetron and hydroxyzine both increase QTc interval. Use Caution/Monitor.
- haloperidol
hydroxyzine and haloperidol both increase sedation. Use Caution/Monitor.hydroxyzine and haloperidol both increase QTc interval. Use Caution/Monitor.
- hawthorn
hawthorn increases effects of hydroxyzine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.
- histrelin
hydroxyzine and histrelin both increase QTc interval. Use Caution/Monitor.
- hops
hops increases effects of hydroxyzine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.
- hyaluronidase
hydroxyzine decreases effects of hyaluronidase by Other (see comment). Use Caution/Monitor. Comment: Antihistamines, when given in large systemic doses, may render tissues partially resistant to the action of hyaluronidase. Patients may require larger amounts of hyaluronidase for equivalent dispersing effect.
- hydromorphone
hydroxyzine and hydromorphone both increase sedation. Use Caution/Monitor.
- iloperidone
hydroxyzine and iloperidone both increase sedation. Use Caution/Monitor.
- imipramine
hydroxyzine and imipramine both increase sedation. Use Caution/Monitor.hydroxyzine and imipramine both increase QTc interval. Use Caution/Monitor.
- inotuzumab
hydroxyzine and inotuzumab both increase QTc interval. Modify Therapy/Monitor Closely. If coadministration necessary, obtain baseline ECG to assess initial QT interval and determine frequency of subsequent monitoring; avoid non-essential QT prolonging drug and correct electrolyte imbalances
- isoproterenol
hydroxyzine increases and isoproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- itraconazole
hydroxyzine and itraconazole both increase QTc interval. Use Caution/Monitor.itraconazole and hydroxyzine both increase QTc interval. Use Caution/Monitor.
- ivosidenib
hydroxyzine and ivosidenib both decrease QTc interval. Modify Therapy/Monitor Closely. If coadministration necessary, obtain baseline ECG to assess initial QT interval and determine frequency of subsequent monitoring; avoid non-essential QT prolonging drug and correct electrolyte imbalances
- kava
kava increases effects of hydroxyzine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.
- ketamine
ketamine and hydroxyzine both increase sedation. Use Caution/Monitor.
- ketotifen, ophthalmic
hydroxyzine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- lapatinib
hydroxyzine and lapatinib both increase QTc interval. Use Caution/Monitor.
- lasmiditan
lasmiditan, hydroxyzine. Either increases effects of the other by sedation. Use Caution/Monitor. Coadministration of lasmiditan and other CNS depressant drugs, including alcohol have not been evaluated in clinical studies. Lasmiditan may cause sedation, as well as other cognitive and/or neuropsychiatric adverse reactions.
- lemborexant
lemborexant, hydroxyzine. Either increases effects of the other by sedation. Modify Therapy/Monitor Closely. Dosage adjustment may be necessary if lemborexant is coadministered with other CNS depressants because of potentially additive effects.
- leuprolide
hydroxyzine and leuprolide both increase QTc interval. Use Caution/Monitor.
- levalbuterol
hydroxyzine increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- levofloxacin
hydroxyzine and levofloxacin both increase QTc interval. Use Caution/Monitor.
- levorphanol
hydroxyzine and levorphanol both increase sedation. Use Caution/Monitor.
- lisdexamfetamine
hydroxyzine increases and lisdexamfetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- lithium
hydroxyzine and lithium both increase QTc interval. Use Caution/Monitor.
- lofepramine
hydroxyzine and lofepramine both increase sedation. Use Caution/Monitor.
- lofexidine
hydroxyzine and lofexidine both increase sedation. Use Caution/Monitor.
- loperamide
hydroxyzine and loperamide both increase QTc interval. Use Caution/Monitor.
- loprazolam
hydroxyzine and loprazolam both increase sedation. Use Caution/Monitor.
- lorazepam
hydroxyzine and lorazepam both increase sedation. Use Caution/Monitor.
- lormetazepam
hydroxyzine and lormetazepam both increase sedation. Use Caution/Monitor.
- loxapine
hydroxyzine and loxapine both increase sedation. Use Caution/Monitor.
- loxapine inhaled
hydroxyzine and loxapine inhaled both increase sedation. Use Caution/Monitor.
- lurasidone
lurasidone, hydroxyzine. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: Potential for increased CNS depressant effects when used concurrently; monitor for increased adverse effects and toxicity.
- maprotiline
hydroxyzine and maprotiline both increase sedation. Use Caution/Monitor.hydroxyzine and maprotiline both increase QTc interval. Use Caution/Monitor.
- marijuana
hydroxyzine and marijuana both increase sedation. Use Caution/Monitor.
- mefloquine
hydroxyzine and mefloquine both increase QTc interval. Use Caution/Monitor.
- melatonin
hydroxyzine and melatonin both increase sedation. Use Caution/Monitor.
- meperidine
hydroxyzine and meperidine both increase sedation. Use Caution/Monitor.
- meprobamate
hydroxyzine and meprobamate both increase sedation. Use Caution/Monitor.
- metaproterenol
hydroxyzine increases and metaproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- metaxalone
hydroxyzine and metaxalone both increase sedation. Use Caution/Monitor.
- methadone
hydroxyzine and methadone both increase sedation. Use Caution/Monitor.hydroxyzine increases toxicity of methadone by QTc interval. Use Caution/Monitor. Increases risk of torsades de pointes.
- methamphetamine
hydroxyzine increases and methamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- methocarbamol
hydroxyzine and methocarbamol both increase sedation. Use Caution/Monitor.
- methylenedioxymethamphetamine
hydroxyzine increases and methylenedioxymethamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- midazolam
hydroxyzine and midazolam both increase sedation. Use Caution/Monitor.
- midazolam intranasal
midazolam intranasal, hydroxyzine. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Concomitant use of barbiturates, alcohol, or other CNS depressants may increase the risk of hypoventilation, airway obstruction, desaturation, or apnea and may contribute to profound and/or prolonged drug effect.
- midodrine
hydroxyzine increases and midodrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- mirtazapine
hydroxyzine and mirtazapine both increase sedation. Use Caution/Monitor.hydroxyzine and mirtazapine both increase QTc interval. Use Caution/Monitor.
- modafinil
hydroxyzine increases and modafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- morphine
hydroxyzine and morphine both increase sedation. Use Caution/Monitor.
- motherwort
hydroxyzine and motherwort both increase sedation. Use Caution/Monitor.
- moxifloxacin
hydroxyzine increases toxicity of moxifloxacin by QTc interval. Use Caution/Monitor. Increases risk of torsades de pointes.
- moxonidine
hydroxyzine and moxonidine both increase sedation. Use Caution/Monitor.
- nabilone
hydroxyzine and nabilone both increase sedation. Use Caution/Monitor.
- nalbuphine
hydroxyzine and nalbuphine both increase sedation. Use Caution/Monitor.
- norepinephrine
hydroxyzine increases and norepinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- nortriptyline
hydroxyzine and nortriptyline both increase sedation. Use Caution/Monitor.hydroxyzine and nortriptyline both increase QTc interval. Use Caution/Monitor.
- octreotide
hydroxyzine and octreotide both increase QTc interval. Use Caution/Monitor.
- ofloxacin
hydroxyzine and ofloxacin both increase QTc interval. Use Caution/Monitor.
- olanzapine
hydroxyzine and olanzapine both increase sedation. Use Caution/Monitor.hydroxyzine and olanzapine both increase QTc interval. Use Caution/Monitor. Limited data, including some case reports, suggest that olanzapine may be associated with a significant prolongation of the QTc interval in rare instances
- ondansetron
hydroxyzine increases toxicity of ondansetron by QTc interval. Use Caution/Monitor. Increases risk of torsades de pointes.
- opium tincture
hydroxyzine and opium tincture both increase sedation. Use Caution/Monitor.
- orphenadrine
hydroxyzine and orphenadrine both increase sedation. Use Caution/Monitor.
- osilodrostat
osilodrostat and hydroxyzine both increase QTc interval. Use Caution/Monitor.
- oxazepam
hydroxyzine and oxazepam both increase sedation. Use Caution/Monitor.
- oxycodone
hydroxyzine and oxycodone both increase sedation. Use Caution/Monitor.
- oxymorphone
hydroxyzine and oxymorphone both increase sedation. Use Caution/Monitor.
- paliperidone
hydroxyzine and paliperidone both increase sedation. Use Caution/Monitor.
- papaveretum
hydroxyzine and papaveretum both increase sedation. Use Caution/Monitor.
- papaverine
hydroxyzine and papaverine both increase sedation. Use Caution/Monitor.
- paroxetine
hydroxyzine and paroxetine both increase QTc interval. Use Caution/Monitor.
- pasireotide
hydroxyzine and pasireotide both increase QTc interval. Use Caution/Monitor.
- passion flower
passion flower increases effects of hydroxyzine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.
- pentamidine
hydroxyzine increases toxicity of pentamidine by QTc interval. Use Caution/Monitor. Increases risk of torsades de pointes.
- pentazocine
hydroxyzine and pentazocine both increase sedation. Use Caution/Monitor.
- pentobarbital
hydroxyzine and pentobarbital both increase sedation. Use Caution/Monitor.
- perampanel
perampanel and hydroxyzine both increase sedation. Use Caution/Monitor.
- perphenazine
hydroxyzine and perphenazine both increase sedation. Use Caution/Monitor.hydroxyzine and perphenazine both increase QTc interval. Use Caution/Monitor.
- phendimetrazine
hydroxyzine increases and phendimetrazine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- phenelzine
phenelzine increases effects of hydroxyzine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Coadministration of phenelzine and antihistamines may result in additive CNS depressant effects. MAO inhibitors also prolong and intensify anticholinergic effects of antihistamines. .
- phenobarbital
hydroxyzine and phenobarbital both increase sedation. Use Caution/Monitor.
- phentermine
hydroxyzine increases and phentermine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- phenylephrine
hydroxyzine increases and phenylephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- phenylephrine PO
hydroxyzine increases and phenylephrine PO decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. .
- pholcodine
hydroxyzine and pholcodine both increase sedation. Use Caution/Monitor.
- pimozide
hydroxyzine and pimozide both increase sedation. Use Caution/Monitor.
- pirbuterol
hydroxyzine increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- posaconazole
hydroxyzine and posaconazole both increase QTc interval. Use Caution/Monitor.
- pregabalin
pregabalin, hydroxyzine. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.
- primaquine
hydroxyzine and primaquine both increase QTc interval. Use Caution/Monitor.
- primidone
hydroxyzine and primidone both increase sedation. Use Caution/Monitor.
- prochlorperazine
hydroxyzine and prochlorperazine both increase sedation. Use Caution/Monitor.hydroxyzine and prochlorperazine both decrease QTc interval. Use Caution/Monitor.
- promethazine
hydroxyzine and promethazine both increase sedation. Use Caution/Monitor.hydroxyzine and promethazine both decrease QTc interval. Use Caution/Monitor.
- propofol
propofol and hydroxyzine both increase sedation. Use Caution/Monitor.
- propylhexedrine
hydroxyzine increases and propylhexedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- protriptyline
hydroxyzine and protriptyline both increase sedation. Use Caution/Monitor.hydroxyzine and protriptyline both increase QTc interval. Use Caution/Monitor.
- quazepam
hydroxyzine and quazepam both increase sedation. Use Caution/Monitor.
- quetiapine
hydroxyzine and quetiapine both increase sedation. Use Caution/Monitor.
- ramelteon
hydroxyzine and ramelteon both increase sedation. Use Caution/Monitor.
- ranolazine
hydroxyzine and ranolazine both increase QTc interval. Use Caution/Monitor.
- rilpivirine
hydroxyzine and rilpivirine both increase QTc interval. Use Caution/Monitor.
- risperidone
hydroxyzine and risperidone both increase sedation. Use Caution/Monitor.hydroxyzine and risperidone both increase QTc interval. Use Caution/Monitor.
- romidepsin
hydroxyzine and romidepsin both increase QTc interval. Use Caution/Monitor.
- salmeterol
hydroxyzine increases and salmeterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- scullcap
hydroxyzine and scullcap both increase sedation. Use Caution/Monitor.
- secobarbital
hydroxyzine and secobarbital both increase sedation. Use Caution/Monitor.
- sertraline
hydroxyzine and sertraline both increase QTc interval. Use Caution/Monitor.
- sevoflurane
sevoflurane and hydroxyzine both increase sedation. Use Caution/Monitor.
- shepherd's purse
hydroxyzine and shepherd's purse both increase sedation. Use Caution/Monitor.
- solifenacin
hydroxyzine and solifenacin both increase QTc interval. Use Caution/Monitor.
- stiripentol
stiripentol, hydroxyzine. Either increases effects of the other by sedation. Use Caution/Monitor. Concomitant use stiripentol with other CNS depressants, including alcohol, may increase the risk of sedation and somnolence.
- sufentanil
hydroxyzine and sufentanil both increase sedation. Use Caution/Monitor.
- sunitinib
hydroxyzine and sunitinib both increase QTc interval. Use Caution/Monitor.
- tacrolimus
hydroxyzine and tacrolimus both increase QTc interval. Use Caution/Monitor.
- tapentadol
hydroxyzine and tapentadol both increase sedation. Use Caution/Monitor.
- telavancin
hydroxyzine and telavancin both increase QTc interval. Use Caution/Monitor.
- temazepam
hydroxyzine and temazepam both increase sedation. Use Caution/Monitor.
- terbutaline
hydroxyzine increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- thioridazine
hydroxyzine and thioridazine both increase sedation. Use Caution/Monitor.
- thiothixene
hydroxyzine and thiothixene both increase sedation. Use Caution/Monitor.
- topiramate
hydroxyzine and topiramate both increase sedation. Modify Therapy/Monitor Closely.
- tramadol
hydroxyzine and tramadol both increase sedation. Use Caution/Monitor.
- trazodone
hydroxyzine and trazodone both increase sedation. Use Caution/Monitor.
- triazolam
hydroxyzine and triazolam both increase sedation. Use Caution/Monitor.
- triclabendazole
hydroxyzine and triclabendazole both increase QTc interval. Use Caution/Monitor.
- triclofos
hydroxyzine and triclofos both increase sedation. Use Caution/Monitor.
- trifluoperazine
hydroxyzine and trifluoperazine both increase sedation. Use Caution/Monitor.hydroxyzine and trifluoperazine both decrease QTc interval. Use Caution/Monitor.
- trimipramine
hydroxyzine and trimipramine both increase sedation. Use Caution/Monitor.hydroxyzine and trimipramine both increase QTc interval. Use Caution/Monitor.
- triprolidine
hydroxyzine and triprolidine both increase sedation. Use Caution/Monitor.
- triptorelin
hydroxyzine and triptorelin both increase QTc interval. Use Caution/Monitor.
- valerian
valerian increases effects of hydroxyzine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.
- vardenafil
hydroxyzine and vardenafil both increase QTc interval. Use Caution/Monitor.
- venlafaxine
hydroxyzine and venlafaxine both decrease QTc interval. Use Caution/Monitor.
- voclosporin
hydroxyzine and voclosporin both increase QTc interval. Use Caution/Monitor.
- vorinostat
hydroxyzine and vorinostat both increase QTc interval. Use Caution/Monitor.
- xylometazoline
hydroxyzine increases and xylometazoline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- yohimbine
hydroxyzine increases and yohimbine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- ziconotide
hydroxyzine and ziconotide both increase sedation. Use Caution/Monitor.
- ziprasidone
hydroxyzine and ziprasidone both increase sedation. Use Caution/Monitor.
- zotepine
hydroxyzine and zotepine both increase sedation. Use Caution/Monitor.
Minor (6)
- ashwagandha
ashwagandha increases effects of hydroxyzine by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.
- brimonidine
brimonidine increases effects of hydroxyzine by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.
- eucalyptus
hydroxyzine and eucalyptus both increase sedation. Minor/Significance Unknown.
- nettle
nettle increases effects of hydroxyzine by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.
- sage
hydroxyzine and sage both increase sedation. Minor/Significance Unknown.
- Siberian ginseng
Siberian ginseng increases effects of hydroxyzine by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.
- albuterol
Monitor Closely (2)hydroxyzine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
albuterol and hydroxyzine both increase QTc interval. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and alfentanil both increase sedation. Use Caution/Monitor.
Monitor Closely (1)alfuzosin and hydroxyzine both increase QTc interval. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and alprazolam both increase sedation. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.
Serious - Use Alternative (1)hydroxyzine increases toxicity of amiodarone by QTc interval. Avoid or Use Alternate Drug. Increases risk of torsades de pointes.
Serious - Use Alternative (1)amisulpride and hydroxyzine both increase QTc interval. Avoid or Use Alternate Drug. ECG monitoring is recommended if coadministered.
Monitor Closely (2)hydroxyzine and amitriptyline both increase QTc interval. Use Caution/Monitor.
hydroxyzine and amitriptyline both increase sedation. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and amobarbital both increase sedation. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and amoxapine both increase sedation. Use Caution/Monitor.
Serious - Use Alternative (1)hydroxyzine and anagrelide both increase QTc interval. Avoid or Use Alternate Drug.
Monitor Closely (2)apomorphine and hydroxyzine both increase QTc interval. Use Caution/Monitor.
hydroxyzine and apomorphine both increase sedation. Use Caution/Monitor.
Monitor Closely (2)arformoterol and hydroxyzine both increase QTc interval. Use Caution/Monitor.
hydroxyzine increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
Monitor Closely (2)aripiprazole and hydroxyzine both increase QTc interval. Use Caution/Monitor.
hydroxyzine and aripiprazole both increase sedation. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine increases and armodafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
Serious - Use Alternative (1)hydroxyzine and arsenic trioxide both increase QTc interval. Avoid or Use Alternate Drug.
Serious - Use Alternative (1)artemether and hydroxyzine both increase QTc interval. Avoid or Use Alternate Drug.
Serious - Use Alternative (1)artemether/lumefantrine and hydroxyzine both increase QTc interval. Avoid or Use Alternate Drug.
Serious - Use Alternative (1)hydroxyzine and asenapine both increase QTc interval. Avoid or Use Alternate Drug.
Minor (1)ashwagandha increases effects of hydroxyzine by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.
Monitor Closely (1)atomoxetine and hydroxyzine both increase QTc interval. Use Caution/Monitor.
Monitor Closely (1)azelastine and hydroxyzine both increase sedation. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine increases toxicity of azithromycin by QTc interval. Use Caution/Monitor. Increases risk of torsades de pointes.
Monitor Closely (1)hydroxyzine and baclofen both increase sedation. Use Caution/Monitor.
Serious - Use Alternative (1)bedaquiline and hydroxyzine both increase QTc interval. Avoid or Use Alternate Drug.
Monitor Closely (1)hydroxyzine and belladonna and opium both increase sedation. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and benperidol both increase sedation. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine increases and benzphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
Monitor Closely (1)brexanolone, hydroxyzine. Either increases toxicity of the other by sedation. Use Caution/Monitor.
Minor (1)brimonidine increases effects of hydroxyzine by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.
Monitor Closely (1)brompheniramine and hydroxyzine both increase sedation. Use Caution/Monitor.
Monitor Closely (2)hydroxyzine and buprenorphine both increase QTc interval. Modify Therapy/Monitor Closely. If coadministration necessary, consider consider dose reduction of one or both drugs due to potential for additive pharmacological effects
hydroxyzine and buprenorphine both increase sedation. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and buprenorphine buccal both increase sedation. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and butabarbital both increase sedation. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and butalbital both increase sedation. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and butorphanol both increase sedation. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
Serious - Use Alternative (1)hydroxyzine, calcium/magnesium/potassium/sodium oxybates. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.
Monitor Closely (1)carbinoxamine and hydroxyzine both increase sedation. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and carisoprodol both increase sedation. Use Caution/Monitor.
Serious - Use Alternative (1)ceritinib and hydroxyzine both increase QTc interval. Avoid or Use Alternate Drug.
Monitor Closely (1)hydroxyzine and chloral hydrate both increase sedation. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and chlordiazepoxide both increase sedation. Use Caution/Monitor.
Serious - Use Alternative (1)chloroquine and hydroxyzine both increase QTc interval. Avoid or Use Alternate Drug.
Monitor Closely (1)chlorpheniramine and hydroxyzine both increase sedation. Use Caution/Monitor.
Monitor Closely (2)hydroxyzine increases toxicity of chlorpromazine by QTc interval. Use Caution/Monitor. Increases risk of torsades de pointes.
hydroxyzine and chlorpromazine both increase sedation. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and chlorzoxazone both increase sedation. Use Caution/Monitor.
Monitor Closely (1)cinnarizine and hydroxyzine both increase sedation. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and ciprofloxacin both increase QTc interval. Use Caution/Monitor.
Serious - Use Alternative (1)hydroxyzine increases toxicity of citalopram by QTc interval. Avoid or Use Alternate Drug. Increases risk of torsades de pointes.
Monitor Closely (1)hydroxyzine increases toxicity of clarithromycin by QTc interval. Use Caution/Monitor. Increases risk of torsades de pointes.
Monitor Closely (1)clemastine and hydroxyzine both increase sedation. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine, clobazam. Other (see comment). Use Caution/Monitor. Comment: Concomitant administration can increase the potential for CNS effects (e.g., increased sedation or respiratory depression).
Monitor Closely (2)hydroxyzine and clomipramine both increase sedation. Use Caution/Monitor.
hydroxyzine and clomipramine both increase QTc interval. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and clonazepam both increase sedation. Use Caution/Monitor.
Monitor Closely (1)clonidine, hydroxyzine. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration enhances CNS depressant effects.
Monitor Closely (1)hydroxyzine and clorazepate both increase sedation. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and clozapine both increase sedation. Use Caution/Monitor.Serious - Use Alternative (1)hydroxyzine increases toxicity of clozapine by QTc interval. Avoid or Use Alternate Drug. Increases risk of torsades de pointes.
Monitor Closely (1)hydroxyzine and codeine both increase sedation. Use Caution/Monitor.
Serious - Use Alternative (1)crizotinib and hydroxyzine both increase QTc interval. Avoid or Use Alternate Drug.
Monitor Closely (1)cyclizine and hydroxyzine both increase sedation. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and cyclobenzaprine both increase sedation. Use Caution/Monitor.
Monitor Closely (1)cyproheptadine and hydroxyzine both increase sedation. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and dantrolene both increase sedation. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and daridorexant both increase sedation. Modify Therapy/Monitor Closely. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment.
Monitor Closely (1)dasatinib and hydroxyzine both increase QTc interval. Use Caution/Monitor.
Monitor Closely (1)degarelix and hydroxyzine both increase QTc interval. Use Caution/Monitor.
Monitor Closely (1)desflurane and hydroxyzine both increase sedation. Use Caution/Monitor.Serious - Use Alternative (1)desflurane and hydroxyzine both increase QTc interval. Avoid or Use Alternate Drug.
Monitor Closely (2)hydroxyzine and desipramine both increase sedation. Use Caution/Monitor.
hydroxyzine and desipramine both increase QTc interval. Use Caution/Monitor.
Monitor Closely (2)hydroxyzine and deutetrabenazine both increase sedation. Use Caution/Monitor.
deutetrabenazine and hydroxyzine both increase QTc interval. Use Caution/Monitor.
Monitor Closely (1)dexchlorpheniramine and hydroxyzine both increase sedation. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine increases and dexfenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and dexmedetomidine both increase sedation. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and dextromoramide both increase sedation. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and diamorphine both increase sedation. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and diazepam both increase sedation. Use Caution/Monitor.
Monitor Closely (1)diazepam intranasal, hydroxyzine. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration may potentiate the CNS-depressant effects of each drug.
Monitor Closely (1)hydroxyzine increases and diethylpropion decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
Monitor Closely (1)difelikefalin and hydroxyzine both increase sedation. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and difenoxin hcl both increase sedation. Use Caution/Monitor.
Monitor Closely (1)dimenhydrinate and hydroxyzine both increase sedation. Use Caution/Monitor.
Monitor Closely (1)diphenhydramine and hydroxyzine both increase sedation. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and diphenoxylate hcl both increase sedation. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and dipipanone both increase sedation. Use Caution/Monitor.
Serious - Use Alternative (1)hydroxyzine and disopyramide both increase QTc interval. Avoid or Use Alternate Drug.
Monitor Closely (1)hydroxyzine increases and dobutamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
Serious - Use Alternative (1)hydroxyzine and dofetilide both increase QTc interval. Avoid or Use Alternate Drug.
Monitor Closely (1)dolasetron and hydroxyzine both increase QTc interval. Use Caution/Monitor.
Monitor Closely (1)donepezil and hydroxyzine both increase QTc interval. Use Caution/Monitor.
Monitor Closely (1)donepezil transdermal, hydroxyzine. Either decreases effects of the other by pharmacodynamic antagonism. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine increases and dopamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine increases and dopexamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and dosulepin both increase sedation. Use Caution/Monitor.
Monitor Closely (2)doxepin and hydroxyzine both increase QTc interval. Use Caution/Monitor.
hydroxyzine and doxepin both increase sedation. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and doxylamine both increase sedation. Use Caution/Monitor.
Contraindicated (1)hydroxyzine and dronedarone both increase QTc interval. Contraindicated.
Monitor Closely (1)hydroxyzine and droperidol both increase sedation. Use Caution/Monitor.Serious - Use Alternative (1)hydroxyzine increases toxicity of droperidol by QTc interval. Avoid or Use Alternate Drug. Increases risk of torsades de pointes.
Monitor Closely (1)efavirenz and hydroxyzine both increase QTc interval. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and eliglustat both increase QTc interval. Use Caution/Monitor.
Serious - Use Alternative (1)hydroxyzine, eluxadoline. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid coadministration with other drugs that cause constipation. Increases risk for constipation related serious adverse reactions.
Serious - Use Alternative (1)encorafenib and hydroxyzine both increase QTc interval. Avoid or Use Alternate Drug.
Serious - Use Alternative (1)entrectinib and hydroxyzine both increase QTc interval. Avoid or Use Alternate Drug.
Monitor Closely (1)hydroxyzine increases and ephedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
Serious - Use Alternative (1)eribulin and hydroxyzine both increase QTc interval. Avoid or Use Alternate Drug.
Monitor Closely (1)hydroxyzine increases toxicity of erythromycin base by QTc interval. Use Caution/Monitor. Increases risk of torsades de pointes.
Monitor Closely (1)hydroxyzine increases toxicity of erythromycin ethylsuccinate by QTc interval. Use Caution/Monitor. Increases risk of torsades de pointes.
Monitor Closely (1)hydroxyzine increases toxicity of erythromycin lactobionate by QTc interval. Use Caution/Monitor. Increases risk of torsades de pointes.
Monitor Closely (1)hydroxyzine increases toxicity of erythromycin stearate by QTc interval. Use Caution/Monitor. Increases risk of torsades de pointes.
Monitor Closely (1)hydroxyzine and escitalopram both increase QTc interval. Use Caution/Monitor.
Monitor Closely (1)esketamine intranasal, hydroxyzine. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.
Monitor Closely (1)hydroxyzine and estazolam both increase sedation. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and ethanol both increase sedation. Use Caution/Monitor.
Monitor Closely (1)etomidate and hydroxyzine both increase sedation. Use Caution/Monitor.
Minor (1)hydroxyzine and eucalyptus both increase sedation. Minor/Significance Unknown.
Monitor Closely (1)hydroxyzine and ezogabine both increase QTc interval. Use Caution/Monitor. Slight and transient QT-prolongation observed, particularly when dose titrated to 1200mg/day. QT interval should be monitored when ezogabine is prescribed with agents known to increase QT interval.
Monitor Closely (1)hydroxyzine increases and fenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
Monitor Closely (1)fentanyl, hydroxyzine. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of fentanyl with anticholinergics may increase risk for urinary retention and/or severe constipation, which may lead to paralytic ileus.
Monitor Closely (1)fentanyl intranasal, hydroxyzine. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of fentanyl with anticholinergics may increase risk for urinary retention and/or severe constipation, which may lead to paralytic ileus.
Monitor Closely (1)fentanyl transdermal, hydroxyzine. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of fentanyl with anticholinergics may increase risk for urinary retention and/or severe constipation, which may lead to paralytic ileus.
Monitor Closely (1)fentanyl transmucosal, hydroxyzine. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of fentanyl with anticholinergics may increase risk for urinary retention and/or severe constipation, which may lead to paralytic ileus.
Serious - Use Alternative (1)fexinidazole and hydroxyzine both increase QTc interval. Avoid or Use Alternate Drug. Avoid coadministration of fexinidazole with drugs known to block potassium channels or prolong QT interval.
Monitor Closely (1)fingolimod and hydroxyzine both increase QTc interval. Use Caution/Monitor.
Serious - Use Alternative (1)hydroxyzine and flecainide both increase QTc interval. Avoid or Use Alternate Drug.
Monitor Closely (1)hydroxyzine and flibanserin both increase sedation. Modify Therapy/Monitor Closely. Risk for sedation increased if flibanserin is coadministration with other CNS depressants.
Monitor Closely (1)hydroxyzine and fluconazole both increase QTc interval. Use Caution/Monitor.
Serious - Use Alternative (1)hydroxyzine increases toxicity of fluoxetine by QTc interval. Avoid or Use Alternate Drug. Increases risk of torsades de pointes.
Monitor Closely (2)hydroxyzine and fluphenazine both increase sedation. Use Caution/Monitor.
hydroxyzine and fluphenazine both increase QTc interval. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and flurazepam both increase sedation. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and fluvoxamine both increase QTc interval. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
Serious - Use Alternative (1)hydroxyzine and foscarnet both increase QTc interval. Avoid or Use Alternate Drug.
Monitor Closely (1)hydroxyzine and fostemsavir both increase QTc interval. Use Caution/Monitor. QTc prolongation reported with higher than recommended doses of fostemsavir.
Monitor Closely (1)gabapentin, hydroxyzine. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.
Monitor Closely (1)gabapentin enacarbil, hydroxyzine. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.
Monitor Closely (1)hydroxyzine and ganaxolone both increase sedation. Use Caution/Monitor.
Monitor Closely (1)gemifloxacin and hydroxyzine both increase QTc interval. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and gemtuzumab both increase QTc interval. Use Caution/Monitor.
Monitor Closely (1)gilteritinib and hydroxyzine both increase QTc interval. Use Caution/Monitor.
Serious - Use Alternative (1)hydroxyzine and glasdegib both increase QTc interval. Avoid or Use Alternate Drug.
Monitor Closely (1)glycopyrronium tosylate topical, hydroxyzine. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration of glycopyrronium tosylate topical with other anticholinergic medications may result in additive anticholinergic adverse effects.
Monitor Closely (1)hydroxyzine and goserelin both increase QTc interval. Use Caution/Monitor.
Monitor Closely (1)gotu kola increases effects of hydroxyzine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.
Monitor Closely (1)granisetron and hydroxyzine both increase QTc interval. Use Caution/Monitor.
Monitor Closely (2)hydroxyzine and haloperidol both increase QTc interval. Use Caution/Monitor.
hydroxyzine and haloperidol both increase sedation. Use Caution/Monitor.
Monitor Closely (1)hawthorn increases effects of hydroxyzine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.
Monitor Closely (1)hydroxyzine and histrelin both increase QTc interval. Use Caution/Monitor.
Monitor Closely (1)hops increases effects of hydroxyzine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.
Monitor Closely (1)hydroxyzine decreases effects of hyaluronidase by Other (see comment). Use Caution/Monitor. Comment: Antihistamines, when given in large systemic doses, may render tissues partially resistant to the action of hyaluronidase. Patients may require larger amounts of hyaluronidase for equivalent dispersing effect.
Monitor Closely (1)hydroxyzine and hydromorphone both increase sedation. Use Caution/Monitor.
Serious - Use Alternative (1)hydroxyzine and hydroxychloroquine sulfate both increase QTc interval. Avoid or Use Alternate Drug.
Serious - Use Alternative (1)hydroxyzine and ibutilide both increase QTc interval. Avoid or Use Alternate Drug.
Monitor Closely (1)hydroxyzine and iloperidone both increase sedation. Use Caution/Monitor.Serious - Use Alternative (1)hydroxyzine increases toxicity of iloperidone by QTc interval. Avoid or Use Alternate Drug. Increases risk of torsades de pointes.
Monitor Closely (2)hydroxyzine and imipramine both increase sedation. Use Caution/Monitor.
hydroxyzine and imipramine both increase QTc interval. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and inotuzumab both increase QTc interval. Modify Therapy/Monitor Closely. If coadministration necessary, obtain baseline ECG to assess initial QT interval and determine frequency of subsequent monitoring; avoid non-essential QT prolonging drug and correct electrolyte imbalances
Serious - Use Alternative (1)isocarboxazid increases effects of hydroxyzine by Other (see comment). Avoid or Use Alternate Drug. Comment: Isocarboxazid should not be administered in combination with antihistamines because of potential additive CNS depressant effects. MAO inhibitors also prolong and intensify anticholinergic effects of antihistamines. .
Serious - Use Alternative (1)hydroxyzine and isoflurane both increase QTc interval. Avoid or Use Alternate Drug.
Monitor Closely (1)hydroxyzine increases and isoproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
Monitor Closely (2)hydroxyzine and itraconazole both increase QTc interval. Use Caution/Monitor.
itraconazole and hydroxyzine both increase QTc interval. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and ivosidenib both decrease QTc interval. Modify Therapy/Monitor Closely. If coadministration necessary, obtain baseline ECG to assess initial QT interval and determine frequency of subsequent monitoring; avoid non-essential QT prolonging drug and correct electrolyte imbalances
Monitor Closely (1)kava increases effects of hydroxyzine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.
Monitor Closely (1)ketamine and hydroxyzine both increase sedation. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and lapatinib both increase QTc interval. Use Caution/Monitor.
Monitor Closely (1)lasmiditan, hydroxyzine. Either increases effects of the other by sedation. Use Caution/Monitor. Coadministration of lasmiditan and other CNS depressant drugs, including alcohol have not been evaluated in clinical studies. Lasmiditan may cause sedation, as well as other cognitive and/or neuropsychiatric adverse reactions.
Serious - Use Alternative (1)lefamulin and hydroxyzine both increase QTc interval. Avoid or Use Alternate Drug.
Monitor Closely (1)lemborexant, hydroxyzine. Either increases effects of the other by sedation. Modify Therapy/Monitor Closely. Dosage adjustment may be necessary if lemborexant is coadministered with other CNS depressants because of potentially additive effects.
Serious - Use Alternative (1)hydroxyzine and lenvatinib both increase QTc interval. Avoid or Use Alternate Drug.
Monitor Closely (1)hydroxyzine and leuprolide both increase QTc interval. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and levofloxacin both increase QTc interval. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and levorphanol both increase sedation. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine increases and lisdexamfetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and lithium both increase QTc interval. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and lofepramine both increase sedation. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and lofexidine both increase sedation. Use Caution/Monitor.Serious - Use Alternative (1)hydroxyzine and lofexidine both increase QTc interval. Avoid or Use Alternate Drug.
Monitor Closely (1)hydroxyzine and loperamide both increase QTc interval. Use Caution/Monitor.
Serious - Use Alternative (1)hydroxyzine and lopinavir both increase QTc interval. Avoid or Use Alternate Drug.
Monitor Closely (1)hydroxyzine and loprazolam both increase sedation. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and lorazepam both increase sedation. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and lormetazepam both increase sedation. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and loxapine both increase sedation. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and loxapine inhaled both increase sedation. Use Caution/Monitor.
Monitor Closely (1)lurasidone, hydroxyzine. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: Potential for increased CNS depressant effects when used concurrently; monitor for increased adverse effects and toxicity.
Serious - Use Alternative (1)hydroxyzine and macimorelin both increase QTc interval. Avoid or Use Alternate Drug.
Monitor Closely (2)hydroxyzine and maprotiline both increase QTc interval. Use Caution/Monitor.
hydroxyzine and maprotiline both increase sedation. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and marijuana both increase sedation. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and mefloquine both increase QTc interval. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and melatonin both increase sedation. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and meperidine both increase sedation. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and meprobamate both increase sedation. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine increases and metaproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and metaxalone both increase sedation. Use Caution/Monitor.
Monitor Closely (2)hydroxyzine increases toxicity of methadone by QTc interval. Use Caution/Monitor. Increases risk of torsades de pointes.
hydroxyzine and methadone both increase sedation. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine increases and methamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and methocarbamol both increase sedation. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine increases and methylenedioxymethamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
Serious - Use Alternative (1)hydroxyzine, metoclopramide intranasal. Either increases effects of the other by Other (see comment). Avoid or Use Alternate Drug. Comment: Avoid use of metoclopramide intranasal or interacting drug, depending on importance of drug to patient.
Monitor Closely (1)hydroxyzine and midazolam both increase sedation. Use Caution/Monitor.
Monitor Closely (1)midazolam intranasal, hydroxyzine. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Concomitant use of barbiturates, alcohol, or other CNS depressants may increase the risk of hypoventilation, airway obstruction, desaturation, or apnea and may contribute to profound and/or prolonged drug effect.
Monitor Closely (1)hydroxyzine increases and midodrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
Serious - Use Alternative (1)hydroxyzine and midostaurin both increase QTc interval. Avoid or Use Alternate Drug.
Serious - Use Alternative (1)hydroxyzine and mifepristone both increase QTc interval. Avoid or Use Alternate Drug.
Monitor Closely (2)hydroxyzine and mirtazapine both increase QTc interval. Use Caution/Monitor.
hydroxyzine and mirtazapine both increase sedation. Use Caution/Monitor.
Serious - Use Alternative (1)hydroxyzine and mobocertinib both increase QTc interval. Avoid or Use Alternate Drug.
Monitor Closely (1)hydroxyzine increases and modafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and morphine both increase sedation. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and motherwort both increase sedation. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine increases toxicity of moxifloxacin by QTc interval. Use Caution/Monitor. Increases risk of torsades de pointes.
Monitor Closely (1)hydroxyzine and moxonidine both increase sedation. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and nabilone both increase sedation. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and nalbuphine both increase sedation. Use Caution/Monitor.
Minor (1)nettle increases effects of hydroxyzine by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.
Serious - Use Alternative (1)hydroxyzine and nilotinib both increase QTc interval. Avoid or Use Alternate Drug.
Monitor Closely (1)hydroxyzine increases and norepinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
Monitor Closely (2)hydroxyzine and nortriptyline both increase QTc interval. Use Caution/Monitor.
hydroxyzine and nortriptyline both increase sedation. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and octreotide both increase QTc interval. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and ofloxacin both increase QTc interval. Use Caution/Monitor.
Monitor Closely (2)hydroxyzine and olanzapine both increase QTc interval. Use Caution/Monitor. Limited data, including some case reports, suggest that olanzapine may be associated with a significant prolongation of the QTc interval in rare instances
hydroxyzine and olanzapine both increase sedation. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine increases toxicity of ondansetron by QTc interval. Use Caution/Monitor. Increases risk of torsades de pointes.
Monitor Closely (1)hydroxyzine and opium tincture both increase sedation. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and orphenadrine both increase sedation. Use Caution/Monitor.
Monitor Closely (1)osilodrostat and hydroxyzine both increase QTc interval. Use Caution/Monitor.
Serious - Use Alternative (1)hydroxyzine and osimertinib both increase QTc interval. Avoid or Use Alternate Drug.
Serious - Use Alternative (1)hydroxyzine and oxaliplatin both increase QTc interval. Avoid or Use Alternate Drug.
Monitor Closely (1)hydroxyzine and oxazepam both increase sedation. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and oxycodone both increase sedation. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and oxymorphone both increase sedation. Use Caution/Monitor.
Serious - Use Alternative (1)hydroxyzine and ozanimod both increase QTc interval. Avoid or Use Alternate Drug.
Monitor Closely (1)hydroxyzine and paliperidone both increase sedation. Use Caution/Monitor.Serious - Use Alternative (1)hydroxyzine and paliperidone both increase QTc interval. Avoid or Use Alternate Drug.
Serious - Use Alternative (1)hydroxyzine and panobinostat both increase QTc interval. Avoid or Use Alternate Drug.
Monitor Closely (1)hydroxyzine and papaveretum both increase sedation. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and papaverine both increase sedation. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and paroxetine both increase QTc interval. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and pasireotide both increase QTc interval. Use Caution/Monitor.
Monitor Closely (1)passion flower increases effects of hydroxyzine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.
Serious - Use Alternative (1)hydroxyzine and pazopanib both increase QTc interval. Avoid or Use Alternate Drug.
Monitor Closely (1)hydroxyzine increases toxicity of pentamidine by QTc interval. Use Caution/Monitor. Increases risk of torsades de pointes.
Monitor Closely (1)hydroxyzine and pentazocine both increase sedation. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and pentobarbital both increase sedation. Use Caution/Monitor.
Monitor Closely (1)perampanel and hydroxyzine both increase sedation. Use Caution/Monitor.
Monitor Closely (2)hydroxyzine and perphenazine both increase sedation. Use Caution/Monitor.
hydroxyzine and perphenazine both increase QTc interval. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine increases and phendimetrazine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
Monitor Closely (1)phenelzine increases effects of hydroxyzine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Coadministration of phenelzine and antihistamines may result in additive CNS depressant effects. MAO inhibitors also prolong and intensify anticholinergic effects of antihistamines. .
Monitor Closely (1)hydroxyzine and phenobarbital both increase sedation. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine increases and phentermine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine increases and phenylephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine increases and phenylephrine PO decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. .
Monitor Closely (1)hydroxyzine and pholcodine both increase sedation. Use Caution/Monitor.
Serious - Use Alternative (1)hydroxyzine and pimavanserin both increase QTc interval. Avoid or Use Alternate Drug.
Monitor Closely (1)hydroxyzine and pimozide both increase sedation. Use Caution/Monitor.Serious - Use Alternative (1)hydroxyzine and pimozide both increase QTc interval. Contraindicated.
Monitor Closely (1)hydroxyzine increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
Serious - Use Alternative (2)hydroxyzine decreases effects of pitolisant by Other (see comment). Avoid or Use Alternate Drug. Comment: Pitolisant increases histamine levels in the brain; therefore, H1 receptor antagonists that cross the blood-brain barrier may reduce the efficacy of pitolisant.
hydroxyzine and pitolisant both increase QTc interval. Avoid or Use Alternate Drug.
Serious - Use Alternative (1)hydroxyzine and ponesimod both increase QTc interval. Avoid or Use Alternate Drug.
Monitor Closely (1)hydroxyzine and posaconazole both increase QTc interval. Use Caution/Monitor.
Monitor Closely (1)pregabalin, hydroxyzine. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.
Monitor Closely (1)hydroxyzine and primaquine both increase QTc interval. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and primidone both increase sedation. Use Caution/Monitor.
Serious - Use Alternative (1)hydroxyzine increases toxicity of procainamide by QTc interval. Avoid or Use Alternate Drug. Increases risk of torsades de pointes.
Monitor Closely (2)hydroxyzine and prochlorperazine both decrease QTc interval. Use Caution/Monitor.
hydroxyzine and prochlorperazine both increase sedation. Use Caution/Monitor.
Monitor Closely (2)hydroxyzine and promethazine both increase sedation. Use Caution/Monitor.
hydroxyzine and promethazine both decrease QTc interval. Use Caution/Monitor.
Serious - Use Alternative (1)hydroxyzine and propafenone both increase QTc interval. Avoid or Use Alternate Drug.
Monitor Closely (1)propofol and hydroxyzine both increase sedation. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine increases and propylhexedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
Monitor Closely (2)hydroxyzine and protriptyline both increase sedation. Use Caution/Monitor.
hydroxyzine and protriptyline both increase QTc interval. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and quazepam both increase sedation. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and quetiapine both increase sedation. Use Caution/Monitor.Serious - Use Alternative (1)hydroxyzine increases toxicity of quetiapine by QTc interval. Avoid or Use Alternate Drug. Increases risk of torsades de pointes.
Serious - Use Alternative (1)hydroxyzine increases toxicity of quinidine by QTc interval. Avoid or Use Alternate Drug. Increases risk of torsades de pointes.
Serious - Use Alternative (1)hydroxyzine and quinine both increase QTc interval. Avoid or Use Alternate Drug.
Monitor Closely (1)hydroxyzine and ramelteon both increase sedation. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and ranolazine both increase QTc interval. Use Caution/Monitor.
Serious - Use Alternative (1)hydroxyzine and ribociclib both increase QTc interval. Avoid or Use Alternate Drug.
Monitor Closely (1)hydroxyzine and rilpivirine both increase QTc interval. Use Caution/Monitor.
Monitor Closely (2)hydroxyzine and risperidone both increase sedation. Use Caution/Monitor.
hydroxyzine and risperidone both increase QTc interval. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and romidepsin both increase QTc interval. Use Caution/Monitor.
Minor (1)hydroxyzine and sage both increase sedation. Minor/Significance Unknown.
Monitor Closely (1)hydroxyzine increases and salmeterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
Serious - Use Alternative (1)hydroxyzine and saquinavir both increase QTc interval. Avoid or Use Alternate Drug.
Monitor Closely (1)hydroxyzine and scullcap both increase sedation. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and secobarbital both increase sedation. Use Caution/Monitor.
Serious - Use Alternative (1)hydroxyzine and selpercatinib both increase QTc interval. Avoid or Use Alternate Drug.
Monitor Closely (1)hydroxyzine and sertraline both increase QTc interval. Use Caution/Monitor.
Monitor Closely (1)sevoflurane and hydroxyzine both increase sedation. Use Caution/Monitor.Serious - Use Alternative (1)hydroxyzine and sevoflurane both increase QTc interval. Avoid or Use Alternate Drug.
Monitor Closely (1)hydroxyzine and shepherd's purse both increase sedation. Use Caution/Monitor.
Minor (1)Siberian ginseng increases effects of hydroxyzine by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.
Serious - Use Alternative (1)hydroxyzine and siponimod both increase QTc interval. Avoid or Use Alternate Drug.
Serious - Use Alternative (1)hydroxyzine, sodium oxybate. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.
Monitor Closely (1)hydroxyzine and solifenacin both increase QTc interval. Use Caution/Monitor.
Serious - Use Alternative (1)hydroxyzine and sorafenib both increase QTc interval. Avoid or Use Alternate Drug.
Serious - Use Alternative (1)hydroxyzine increases toxicity of sotalol by QTc interval. Avoid or Use Alternate Drug. Increases risk of torsades de pointes.
Monitor Closely (1)stiripentol, hydroxyzine. Either increases effects of the other by sedation. Use Caution/Monitor. Concomitant use stiripentol with other CNS depressants, including alcohol, may increase the risk of sedation and somnolence.
Monitor Closely (1)hydroxyzine and sufentanil both increase sedation. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and sunitinib both increase QTc interval. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and tacrolimus both increase QTc interval. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and tapentadol both increase sedation. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and telavancin both increase QTc interval. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and temazepam both increase sedation. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
Serious - Use Alternative (1)hydroxyzine and tetrabenazine both increase QTc interval. Avoid or Use Alternate Drug.
Contraindicated (1)hydroxyzine and thioridazine both increase QTc interval. Contraindicated.Monitor Closely (1)hydroxyzine and thioridazine both increase sedation. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and thiothixene both increase sedation. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and topiramate both increase sedation. Modify Therapy/Monitor Closely.
Serious - Use Alternative (1)hydroxyzine and toremifene both increase QTc interval. Avoid or Use Alternate Drug.
Monitor Closely (1)hydroxyzine and tramadol both increase sedation. Use Caution/Monitor.
Serious - Use Alternative (1)tranylcypromine increases effects of hydroxyzine by Other (see comment). Avoid or Use Alternate Drug. Comment: Tranylcypromine should not be administered in combination with antihistamines because of potential additive CNS depressant effects. MAO inhibitors also prolong and intensify anticholinergic effects of antihistamines.
Monitor Closely (1)hydroxyzine and trazodone both increase sedation. Use Caution/Monitor.Serious - Use Alternative (1)hydroxyzine and trazodone both increase QTc interval. Avoid or Use Alternate Drug.
Monitor Closely (1)hydroxyzine and triazolam both increase sedation. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and triclabendazole both increase QTc interval. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and triclofos both increase sedation. Use Caution/Monitor.
Monitor Closely (2)hydroxyzine and trifluoperazine both increase sedation. Use Caution/Monitor.
hydroxyzine and trifluoperazine both decrease QTc interval. Use Caution/Monitor.
Monitor Closely (2)hydroxyzine and trimipramine both increase sedation. Use Caution/Monitor.
hydroxyzine and trimipramine both increase QTc interval. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and triprolidine both increase sedation. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and triptorelin both increase QTc interval. Use Caution/Monitor.
Monitor Closely (1)valerian increases effects of hydroxyzine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.
Serious - Use Alternative (1)hydroxyzine and vandetanib both increase QTc interval. Avoid or Use Alternate Drug.
Monitor Closely (1)hydroxyzine and vardenafil both increase QTc interval. Use Caution/Monitor.
Serious - Use Alternative (1)hydroxyzine and vemurafenib both increase QTc interval. Avoid or Use Alternate Drug.
Monitor Closely (1)hydroxyzine and venlafaxine both decrease QTc interval. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and voclosporin both increase QTc interval. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and vorinostat both increase QTc interval. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine increases and xylometazoline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine increases and yohimbine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and ziconotide both increase sedation. Use Caution/Monitor.
Monitor Closely (1)hydroxyzine and ziprasidone both increase sedation. Use Caution/Monitor.Serious - Use Alternative (1)hydroxyzine increases toxicity of ziprasidone by QTc interval. Avoid or Use Alternate Drug. Increases risk of torsades de pointes.
Monitor Closely (1)hydroxyzine and zotepine both increase sedation. Use Caution/Monitor.