For which adverse effect does the nurse monitor in a patient taking hydroxyzine?

Hydroxyzine oral tablets can cause mild or serious side effects. The following lists contain some of the key side effects that may occur while taking hydroxyzine oral tablets. These lists do not include all possible side effects.

For more information about the possible side effects of hydroxyzine oral tablets, talk with your doctor or pharmacist. They can give you tips on how to deal with any side effects that may be concerning or bothersome.

Side effects in women who take hydroxyzine are the same as those that occur in men.*

Note: The Food and Drug Administration (FDA) tracks side effects of drugs it has approved. If you would like to notify the FDA about a side effect you’ve had with hydroxyzine oral tablets, you can do so through MedWatch.

* Sex and gender exist on spectrums. Use of the terms “women” and “men” in this article refers to sex assigned at birth.

Mild side effects

Mild side effects* of hydroxyzine oral tablets can include:

Most of these side effects may go away within a few days or a couple of weeks. But if they become more severe or don’t go away, talk with your doctor or pharmacist.

* This is a partial list of mild side effects from hydroxyzine oral tablets. To learn about other mild side effects, talk with your doctor or pharmacist or view the prescribing information for hydroxyzine oral tablets.
† For more information about this side effect, see “Side effect details” below.

Serious side effects

Serious side effects from hydroxyzine oral tablets aren’t common, but they can occur. Call your doctor right away if you have serious side effects. Call 911 or your local emergency number if your symptoms feel life threatening or if you think you’re having a medical emergency.

Serious side effects and their symptoms can include:

* For more information about this side effect, see “Side effect details” below.

Side effects in children

Children may be more likely to have convulsions as a side effect from taking hydroxyzine.

However, it’s important to note that this side effect wasn’t reported in clinical trials of hydroxyzine. These reports came after the drug was approved. Since these reports happened outside of clinical trials, it’s not clear if hydroxyzine caused the side effect. Other factors could also cause convulsions in people taking hydroxyzine oral tablets.

In addition, children may be more likely to have other side effects from hydroxyzine, such as:

• confusion or being unable to concentrate
• sleepiness
• fatigue (lack of energy)
• weakness

It’s very important that your child takes the exact dose of hydroxyzine prescribed for them. This helps minimize their risk for side effects.

If you have additional questions about hydroxyzine side effects in children, talk with your doctor or pharmacist.

Side effect details

Here’s some detail on certain side effects this drug may cause.

Sleepiness

Sleepiness is a possible side effect from taking hydroxyzine oral tablets. The side effect was commonly reported by people taking the drug in clinical trials. This isn’t unexpected, based on how the drug works. (For more information, see the “How hydroxyzine oral tablet works” section below.)

When you first start taking hydroxyzine, you should avoid driving a car or operating machinery until you know how the drug will affect you. You should also avoid consuming alcohol and using other medications that can cause sleepiness.

If you’re taking hydroxyzine and have sleepiness that is bothersome to you, talk with your doctor or pharmacist. They may be able to suggest ways to improve your energy levels. They may also suggest that you stop taking hydroxyzine and try other treatments for your condition.

Low blood pressure

Based on how hydroxyzine works, you may have low blood pressure as a side effect of taking this drug. (For more information, see the “How hydroxyzine oral tablet works” section below.)

Low blood pressure wasn’t reported by people taking hydroxyzine in clinical trials. But it has been reported since hydroxyzine was approved by the FDA.

Some people may not have symptoms when they have low blood pressure, but others might. Symptoms can include:

• dizziness
• nausea
• being unable to concentrate

Some of these symptoms are also potential side effects of hydroxyzine. So it may be hard to tell if you have a mild case of low blood pressure.

If your blood pressure becomes dangerously low, you may have symptoms such as:

• blurry vision
• cold, clammy skin
• fainting
• rapid, shallow breathing

If you’re having symptoms of low blood pressure while taking hydroxyzine, contact your doctor as soon as you can. They’ll let you know whether you need medical attention. They can also help determine whether hydroxyzine or other factors could be causing this side effect.

Depending on the cause of your low blood pressure, your doctor may recommend ways to treat this side effect. They may also suggest that you stop taking hydroxyzine and try a different medication to treat your condition.

Fatigue

You may experience fatigue (lack of energy) while taking hydroxyzine. This side effect was commonly reported by people who took the medication in clinical trials.

With fatigue, you feel a noticeable lack of energy. This happens despite getting enough sleep and eating the right number of calories for you.

Based on how hydroxyzine oral tablets work, this side effect isn’t unexpected. (For more information, see the “How hydroxyzine oral tablet works” section below.)

Healthcare professionals are used to seeing this side effect from hydroxyzine. So you should talk with your doctor or pharmacist if you’re having fatigue while taking this drug. Even if your fatigue is mild, they may be able to suggest ways to improve your energy levels.

If the fatigue doesn’t go away or is bothering you, your doctor may suggest that you stop taking hydroxyzine and try other treatments for your condition.

Allergic reaction

As with most drugs, some people can have an allergic reaction after taking hydroxyzine oral tablets.

Symptoms of a mild allergic reaction can include:

• skin rash
• itchiness
• flushing (temporary warmth, redness, or deepening of skin color)

A more severe allergic reaction is rare but possible. Symptoms of a severe allergic reaction can include:

• swelling under your skin, typically in your eyelids, lips, hands, or feet
• swelling of your tongue, mouth, or throat
• trouble breathing

Call your doctor right away if you have an allergic reaction to hydroxyzine oral tablets, as the reaction could become severe. Call 911 or your local emergency number if your symptoms feel life threatening or if you think you’re having a medical emergency.

No Interactions Found

Interactions Found

Contraindicated

Serious - Use Alternative

Significant - Monitor Closely

Minor

All Interactions Sort By: SeverityName

Contraindicated (2)

• dronedarone

  hydroxyzine and dronedarone both increase QTc interval. Contraindicated.

• thioridazine

  hydroxyzine and thioridazine both increase QTc interval. Contraindicated.

Serious - Use Alternative (72)

• amiodarone

  hydroxyzine increases toxicity of amiodarone by QTc interval. Avoid or Use Alternate Drug. Increases risk of torsades de pointes.

• amisulpride

  amisulpride and hydroxyzine both increase QTc interval. Avoid or Use Alternate Drug. ECG monitoring is recommended if coadministered.

• anagrelide

  hydroxyzine and anagrelide both increase QTc interval. Avoid or Use Alternate Drug.

• arsenic trioxide

  hydroxyzine and arsenic trioxide both increase QTc interval. Avoid or Use Alternate Drug.

• artemether

  artemether and hydroxyzine both increase QTc interval. Avoid or Use Alternate Drug.

• artemether/lumefantrine

  artemether/lumefantrine and hydroxyzine both increase QTc interval. Avoid or Use Alternate Drug.

• asenapine

  hydroxyzine and asenapine both increase QTc interval. Avoid or Use Alternate Drug.

• bedaquiline

  bedaquiline and hydroxyzine both increase QTc interval. Avoid or Use Alternate Drug.

• calcium/magnesium/potassium/sodium oxybates

  hydroxyzine, calcium/magnesium/potassium/sodium oxybates. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.

• ceritinib

  ceritinib and hydroxyzine both increase QTc interval. Avoid or Use Alternate Drug.

• chloroquine

  chloroquine and hydroxyzine both increase QTc interval. Avoid or Use Alternate Drug.

• citalopram

  hydroxyzine increases toxicity of citalopram by QTc interval. Avoid or Use Alternate Drug. Increases risk of torsades de pointes.

• clozapine

  hydroxyzine increases toxicity of clozapine by QTc interval. Avoid or Use Alternate Drug. Increases risk of torsades de pointes.

• crizotinib

  crizotinib and hydroxyzine both increase QTc interval. Avoid or Use Alternate Drug.

• desflurane

  desflurane and hydroxyzine both increase QTc interval. Avoid or Use Alternate Drug.

• disopyramide

  hydroxyzine and disopyramide both increase QTc interval. Avoid or Use Alternate Drug.

• dofetilide

  hydroxyzine and dofetilide both increase QTc interval. Avoid or Use Alternate Drug.

• droperidol

  hydroxyzine increases toxicity of droperidol by QTc interval. Avoid or Use Alternate Drug. Increases risk of torsades de pointes.

• eluxadoline

  hydroxyzine, eluxadoline. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid coadministration with other drugs that cause constipation. Increases risk for constipation related serious adverse reactions.

• encorafenib

  encorafenib and hydroxyzine both increase QTc interval. Avoid or Use Alternate Drug.

• entrectinib

  entrectinib and hydroxyzine both increase QTc interval. Avoid or Use Alternate Drug.

• eribulin

  eribulin and hydroxyzine both increase QTc interval. Avoid or Use Alternate Drug.

• fexinidazole

  fexinidazole and hydroxyzine both increase QTc interval. Avoid or Use Alternate Drug. Avoid coadministration of fexinidazole with drugs known to block potassium channels or prolong QT interval.

• flecainide

  hydroxyzine and flecainide both increase QTc interval. Avoid or Use Alternate Drug.

• fluoxetine

  hydroxyzine increases toxicity of fluoxetine by QTc interval. Avoid or Use Alternate Drug. Increases risk of torsades de pointes.

• foscarnet

  hydroxyzine and foscarnet both increase QTc interval. Avoid or Use Alternate Drug.

• glasdegib

  hydroxyzine and glasdegib both increase QTc interval. Avoid or Use Alternate Drug.

• hydroxychloroquine sulfate

  hydroxyzine and hydroxychloroquine sulfate both increase QTc interval. Avoid or Use Alternate Drug.

• ibutilide

  hydroxyzine and ibutilide both increase QTc interval. Avoid or Use Alternate Drug.

• iloperidone

  hydroxyzine increases toxicity of iloperidone by QTc interval. Avoid or Use Alternate Drug. Increases risk of torsades de pointes.

• isocarboxazid

  isocarboxazid increases effects of hydroxyzine by Other (see comment). Avoid or Use Alternate Drug. Comment: Isocarboxazid should not be administered in combination with antihistamines because of potential additive CNS depressant effects. MAO inhibitors also prolong and intensify anticholinergic effects of antihistamines. .

• isoflurane

  hydroxyzine and isoflurane both increase QTc interval. Avoid or Use Alternate Drug.

• lefamulin

  lefamulin and hydroxyzine both increase QTc interval. Avoid or Use Alternate Drug.

• lenvatinib

  hydroxyzine and lenvatinib both increase QTc interval. Avoid or Use Alternate Drug.

• lofexidine

  hydroxyzine and lofexidine both increase QTc interval. Avoid or Use Alternate Drug.

• lopinavir

  hydroxyzine and lopinavir both increase QTc interval. Avoid or Use Alternate Drug.

• macimorelin

  hydroxyzine and macimorelin both increase QTc interval. Avoid or Use Alternate Drug.

• metoclopramide intranasal

  hydroxyzine, metoclopramide intranasal. Either increases effects of the other by Other (see comment). Avoid or Use Alternate Drug. Comment: Avoid use of metoclopramide intranasal or interacting drug, depending on importance of drug to patient.

• midostaurin

  hydroxyzine and midostaurin both increase QTc interval. Avoid or Use Alternate Drug.

• mifepristone

  hydroxyzine and mifepristone both increase QTc interval. Avoid or Use Alternate Drug.

• mobocertinib

  hydroxyzine and mobocertinib both increase QTc interval. Avoid or Use Alternate Drug.

• nilotinib

  hydroxyzine and nilotinib both increase QTc interval. Avoid or Use Alternate Drug.

• osimertinib

  hydroxyzine and osimertinib both increase QTc interval. Avoid or Use Alternate Drug.

• oxaliplatin

  hydroxyzine and oxaliplatin both increase QTc interval. Avoid or Use Alternate Drug.

• ozanimod

  hydroxyzine and ozanimod both increase QTc interval. Avoid or Use Alternate Drug.

• paliperidone

  hydroxyzine and paliperidone both increase QTc interval. Avoid or Use Alternate Drug.

• panobinostat

  hydroxyzine and panobinostat both increase QTc interval. Avoid or Use Alternate Drug.

• pazopanib

  hydroxyzine and pazopanib both increase QTc interval. Avoid or Use Alternate Drug.

• pimavanserin

  hydroxyzine and pimavanserin both increase QTc interval. Avoid or Use Alternate Drug.

• pimozide

  hydroxyzine and pimozide both increase QTc interval. Contraindicated.

• pitolisant

  hydroxyzine decreases effects of pitolisant by Other (see comment). Avoid or Use Alternate Drug. Comment: Pitolisant increases histamine levels in the brain; therefore, H1 receptor antagonists that cross the blood-brain barrier may reduce the efficacy of pitolisant.hydroxyzine and pitolisant both increase QTc interval. Avoid or Use Alternate Drug.

• ponesimod

  hydroxyzine and ponesimod both increase QTc interval. Avoid or Use Alternate Drug.

• procainamide

  hydroxyzine increases toxicity of procainamide by QTc interval. Avoid or Use Alternate Drug. Increases risk of torsades de pointes.

• propafenone

  hydroxyzine and propafenone both increase QTc interval. Avoid or Use Alternate Drug.

• quetiapine

  hydroxyzine increases toxicity of quetiapine by QTc interval. Avoid or Use Alternate Drug. Increases risk of torsades de pointes.

• quinidine

  hydroxyzine increases toxicity of quinidine by QTc interval. Avoid or Use Alternate Drug. Increases risk of torsades de pointes.

• quinine

  hydroxyzine and quinine both increase QTc interval. Avoid or Use Alternate Drug.

• ribociclib

  hydroxyzine and ribociclib both increase QTc interval. Avoid or Use Alternate Drug.

• saquinavir

  hydroxyzine and saquinavir both increase QTc interval. Avoid or Use Alternate Drug.

• selpercatinib

  hydroxyzine and selpercatinib both increase QTc interval. Avoid or Use Alternate Drug.

• sevoflurane

  hydroxyzine and sevoflurane both increase QTc interval. Avoid or Use Alternate Drug.

• siponimod

  hydroxyzine and siponimod both increase QTc interval. Avoid or Use Alternate Drug.

• sodium oxybate

  hydroxyzine, sodium oxybate. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.

• sorafenib

  hydroxyzine and sorafenib both increase QTc interval. Avoid or Use Alternate Drug.

• sotalol

  hydroxyzine increases toxicity of sotalol by QTc interval. Avoid or Use Alternate Drug. Increases risk of torsades de pointes.

• tetrabenazine

  hydroxyzine and tetrabenazine both increase QTc interval. Avoid or Use Alternate Drug.

• toremifene

  hydroxyzine and toremifene both increase QTc interval. Avoid or Use Alternate Drug.

• tranylcypromine

  tranylcypromine increases effects of hydroxyzine by Other (see comment). Avoid or Use Alternate Drug. Comment: Tranylcypromine should not be administered in combination with antihistamines because of potential additive CNS depressant effects. MAO inhibitors also prolong and intensify anticholinergic effects of antihistamines.

• trazodone

  hydroxyzine and trazodone both increase QTc interval. Avoid or Use Alternate Drug.

• vandetanib

  hydroxyzine and vandetanib both increase QTc interval. Avoid or Use Alternate Drug.

• vemurafenib

  hydroxyzine and vemurafenib both increase QTc interval. Avoid or Use Alternate Drug.

• ziprasidone

  hydroxyzine increases toxicity of ziprasidone by QTc interval. Avoid or Use Alternate Drug. Increases risk of torsades de pointes.

Monitor Closely (260)

• albuterol

  hydroxyzine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.albuterol and hydroxyzine both increase QTc interval. Use Caution/Monitor.

• alfentanil

  hydroxyzine and alfentanil both increase sedation. Use Caution/Monitor.

• alfuzosin

  alfuzosin and hydroxyzine both increase QTc interval. Use Caution/Monitor.

• alprazolam

  hydroxyzine and alprazolam both increase sedation. Use Caution/Monitor.

• amifampridine

  hydroxyzine increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.

• amitriptyline

  hydroxyzine and amitriptyline both increase sedation. Use Caution/Monitor.hydroxyzine and amitriptyline both increase QTc interval. Use Caution/Monitor.

• amobarbital

  hydroxyzine and amobarbital both increase sedation. Use Caution/Monitor.

• amoxapine

  hydroxyzine and amoxapine both increase sedation. Use Caution/Monitor.

• apomorphine

  hydroxyzine and apomorphine both increase sedation. Use Caution/Monitor.apomorphine and hydroxyzine both increase QTc interval. Use Caution/Monitor.

• arformoterol

  hydroxyzine increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.arformoterol and hydroxyzine both increase QTc interval. Use Caution/Monitor.

• aripiprazole

  hydroxyzine and aripiprazole both increase sedation. Use Caution/Monitor.aripiprazole and hydroxyzine both increase QTc interval. Use Caution/Monitor.

• armodafinil

  hydroxyzine increases and armodafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• atomoxetine

  atomoxetine and hydroxyzine both increase QTc interval. Use Caution/Monitor.

• azelastine

  azelastine and hydroxyzine both increase sedation. Use Caution/Monitor.

• azithromycin

  hydroxyzine increases toxicity of azithromycin by QTc interval. Use Caution/Monitor. Increases risk of torsades de pointes.

• baclofen

  hydroxyzine and baclofen both increase sedation. Use Caution/Monitor.

• belladonna and opium

  hydroxyzine and belladonna and opium both increase sedation. Use Caution/Monitor.

• benperidol

  hydroxyzine and benperidol both increase sedation. Use Caution/Monitor.

• benzphetamine

  hydroxyzine increases and benzphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• brexanolone

  brexanolone, hydroxyzine. Either increases toxicity of the other by sedation. Use Caution/Monitor.

• brompheniramine

  brompheniramine and hydroxyzine both increase sedation. Use Caution/Monitor.

• buprenorphine

  hydroxyzine and buprenorphine both increase sedation. Use Caution/Monitor.hydroxyzine and buprenorphine both increase QTc interval. Modify Therapy/Monitor Closely. If coadministration necessary, consider consider dose reduction of one or both drugs due to potential for additive pharmacological effects

• buprenorphine buccal

  hydroxyzine and buprenorphine buccal both increase sedation. Use Caution/Monitor.

• butabarbital

  hydroxyzine and butabarbital both increase sedation. Use Caution/Monitor.

• butalbital

  hydroxyzine and butalbital both increase sedation. Use Caution/Monitor.

• butorphanol

  hydroxyzine and butorphanol both increase sedation. Use Caution/Monitor.

• caffeine

  hydroxyzine increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• carbinoxamine

  carbinoxamine and hydroxyzine both increase sedation. Use Caution/Monitor.

• carisoprodol

  hydroxyzine and carisoprodol both increase sedation. Use Caution/Monitor.

• chloral hydrate

  hydroxyzine and chloral hydrate both increase sedation. Use Caution/Monitor.

• chlordiazepoxide

  hydroxyzine and chlordiazepoxide both increase sedation. Use Caution/Monitor.

• chlorpheniramine

  chlorpheniramine and hydroxyzine both increase sedation. Use Caution/Monitor.

• chlorpromazine

  hydroxyzine and chlorpromazine both increase sedation. Use Caution/Monitor.hydroxyzine increases toxicity of chlorpromazine by QTc interval. Use Caution/Monitor. Increases risk of torsades de pointes.

• chlorzoxazone

  hydroxyzine and chlorzoxazone both increase sedation. Use Caution/Monitor.

• cinnarizine

  cinnarizine and hydroxyzine both increase sedation. Use Caution/Monitor.

• ciprofloxacin

  hydroxyzine and ciprofloxacin both increase QTc interval. Use Caution/Monitor.

• clarithromycin

  hydroxyzine increases toxicity of clarithromycin by QTc interval. Use Caution/Monitor. Increases risk of torsades de pointes.

• clemastine

  clemastine and hydroxyzine both increase sedation. Use Caution/Monitor.

• clobazam

  hydroxyzine, clobazam. Other (see comment). Use Caution/Monitor. Comment: Concomitant administration can increase the potential for CNS effects (e.g., increased sedation or respiratory depression).

• clomipramine

  hydroxyzine and clomipramine both increase sedation. Use Caution/Monitor.hydroxyzine and clomipramine both increase QTc interval. Use Caution/Monitor.

• clonazepam

  hydroxyzine and clonazepam both increase sedation. Use Caution/Monitor.

• clonidine

  clonidine, hydroxyzine. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration enhances CNS depressant effects.

• clorazepate

  hydroxyzine and clorazepate both increase sedation. Use Caution/Monitor.

• clozapine

  hydroxyzine and clozapine both increase sedation. Use Caution/Monitor.

• codeine

  hydroxyzine and codeine both increase sedation. Use Caution/Monitor.

• cyclizine

  cyclizine and hydroxyzine both increase sedation. Use Caution/Monitor.

• cyclobenzaprine

  hydroxyzine and cyclobenzaprine both increase sedation. Use Caution/Monitor.

• cyproheptadine

  cyproheptadine and hydroxyzine both increase sedation. Use Caution/Monitor.

• dantrolene

  hydroxyzine and dantrolene both increase sedation. Use Caution/Monitor.

• daridorexant

  hydroxyzine and daridorexant both increase sedation. Modify Therapy/Monitor Closely. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment.

• dasatinib

  dasatinib and hydroxyzine both increase QTc interval. Use Caution/Monitor.

• degarelix

  degarelix and hydroxyzine both increase QTc interval. Use Caution/Monitor.

• desflurane

  desflurane and hydroxyzine both increase sedation. Use Caution/Monitor.

• desipramine

  hydroxyzine and desipramine both increase sedation. Use Caution/Monitor.hydroxyzine and desipramine both increase QTc interval. Use Caution/Monitor.

• deutetrabenazine

  hydroxyzine and deutetrabenazine both increase sedation. Use Caution/Monitor.deutetrabenazine and hydroxyzine both increase QTc interval. Use Caution/Monitor.

• dexchlorpheniramine

  dexchlorpheniramine and hydroxyzine both increase sedation. Use Caution/Monitor.

• dexfenfluramine

  hydroxyzine increases and dexfenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• dexmedetomidine

  hydroxyzine and dexmedetomidine both increase sedation. Use Caution/Monitor.

• dexmethylphenidate

  hydroxyzine increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• dextroamphetamine

  hydroxyzine increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• dextromoramide

  hydroxyzine and dextromoramide both increase sedation. Use Caution/Monitor.

• diamorphine

  hydroxyzine and diamorphine both increase sedation. Use Caution/Monitor.

• diazepam

  hydroxyzine and diazepam both increase sedation. Use Caution/Monitor.

• diazepam intranasal

  diazepam intranasal, hydroxyzine. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration may potentiate the CNS-depressant effects of each drug.

• diethylpropion

  hydroxyzine increases and diethylpropion decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• difelikefalin

  difelikefalin and hydroxyzine both increase sedation. Use Caution/Monitor.

• difenoxin hcl

  hydroxyzine and difenoxin hcl both increase sedation. Use Caution/Monitor.

• dimenhydrinate

  dimenhydrinate and hydroxyzine both increase sedation. Use Caution/Monitor.

• diphenhydramine

  diphenhydramine and hydroxyzine both increase sedation. Use Caution/Monitor.

• diphenoxylate hcl

  hydroxyzine and diphenoxylate hcl both increase sedation. Use Caution/Monitor.

• dipipanone

  hydroxyzine and dipipanone both increase sedation. Use Caution/Monitor.

• dobutamine

  hydroxyzine increases and dobutamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• dolasetron

  dolasetron and hydroxyzine both increase QTc interval. Use Caution/Monitor.

• donepezil

  donepezil and hydroxyzine both increase QTc interval. Use Caution/Monitor.

• donepezil transdermal

  donepezil transdermal, hydroxyzine. Either decreases effects of the other by pharmacodynamic antagonism. Use Caution/Monitor.

• dopamine

  hydroxyzine increases and dopamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• dopexamine

  hydroxyzine increases and dopexamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• dosulepin

  hydroxyzine and dosulepin both increase sedation. Use Caution/Monitor.

• doxepin

  hydroxyzine and doxepin both increase sedation. Use Caution/Monitor.doxepin and hydroxyzine both increase QTc interval. Use Caution/Monitor.

• doxylamine

  hydroxyzine and doxylamine both increase sedation. Use Caution/Monitor.

• droperidol

  hydroxyzine and droperidol both increase sedation. Use Caution/Monitor.

• efavirenz

  efavirenz and hydroxyzine both increase QTc interval. Use Caution/Monitor.

• eliglustat

  hydroxyzine and eliglustat both increase QTc interval. Use Caution/Monitor.

• ephedrine

  hydroxyzine increases and ephedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• epinephrine

  hydroxyzine increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• epinephrine racemic

  hydroxyzine increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• erythromycin base

  hydroxyzine increases toxicity of erythromycin base by QTc interval. Use Caution/Monitor. Increases risk of torsades de pointes.

• erythromycin ethylsuccinate

  hydroxyzine increases toxicity of erythromycin ethylsuccinate by QTc interval. Use Caution/Monitor. Increases risk of torsades de pointes.

• erythromycin lactobionate

  hydroxyzine increases toxicity of erythromycin lactobionate by QTc interval. Use Caution/Monitor. Increases risk of torsades de pointes.

• erythromycin stearate

  hydroxyzine increases toxicity of erythromycin stearate by QTc interval. Use Caution/Monitor. Increases risk of torsades de pointes.

• escitalopram

  hydroxyzine and escitalopram both increase QTc interval. Use Caution/Monitor.

• esketamine intranasal

  esketamine intranasal, hydroxyzine. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.

• estazolam

  hydroxyzine and estazolam both increase sedation. Use Caution/Monitor.

• ethanol

  hydroxyzine and ethanol both increase sedation. Use Caution/Monitor.

• etomidate

  etomidate and hydroxyzine both increase sedation. Use Caution/Monitor.

• ezogabine

  hydroxyzine and ezogabine both increase QTc interval. Use Caution/Monitor. Slight and transient QT-prolongation observed, particularly when dose titrated to 1200mg/day. QT interval should be monitored when ezogabine is prescribed with agents known to increase QT interval.

• fenfluramine

  hydroxyzine increases and fenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• fentanyl

  fentanyl, hydroxyzine. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of fentanyl with anticholinergics may increase risk for urinary retention and/or severe constipation, which may lead to paralytic ileus.

• fentanyl intranasal

  fentanyl intranasal, hydroxyzine. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of fentanyl with anticholinergics may increase risk for urinary retention and/or severe constipation, which may lead to paralytic ileus.

• fentanyl transdermal

  fentanyl transdermal, hydroxyzine. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of fentanyl with anticholinergics may increase risk for urinary retention and/or severe constipation, which may lead to paralytic ileus.

• fentanyl transmucosal

  fentanyl transmucosal, hydroxyzine. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of fentanyl with anticholinergics may increase risk for urinary retention and/or severe constipation, which may lead to paralytic ileus.

• fingolimod

  fingolimod and hydroxyzine both increase QTc interval. Use Caution/Monitor.

• flibanserin

  hydroxyzine and flibanserin both increase sedation. Modify Therapy/Monitor Closely. Risk for sedation increased if flibanserin is coadministration with other CNS depressants.

• fluconazole

  hydroxyzine and fluconazole both increase QTc interval. Use Caution/Monitor.

• fluphenazine

  hydroxyzine and fluphenazine both increase sedation. Use Caution/Monitor.hydroxyzine and fluphenazine both increase QTc interval. Use Caution/Monitor.

• flurazepam

  hydroxyzine and flurazepam both increase sedation. Use Caution/Monitor.

• fluvoxamine

  hydroxyzine and fluvoxamine both increase QTc interval. Use Caution/Monitor.

• formoterol

  hydroxyzine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• fostemsavir

  hydroxyzine and fostemsavir both increase QTc interval. Use Caution/Monitor. QTc prolongation reported with higher than recommended doses of fostemsavir.

• gabapentin

  gabapentin, hydroxyzine. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.

• gabapentin enacarbil

  gabapentin enacarbil, hydroxyzine. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.

• ganaxolone

  hydroxyzine and ganaxolone both increase sedation. Use Caution/Monitor.

• gemifloxacin

  gemifloxacin and hydroxyzine both increase QTc interval. Use Caution/Monitor.

• gemtuzumab

  hydroxyzine and gemtuzumab both increase QTc interval. Use Caution/Monitor.

• gilteritinib

  gilteritinib and hydroxyzine both increase QTc interval. Use Caution/Monitor.

• glycopyrronium tosylate topical

  glycopyrronium tosylate topical, hydroxyzine. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration of glycopyrronium tosylate topical with other anticholinergic medications may result in additive anticholinergic adverse effects.

• goserelin

  hydroxyzine and goserelin both increase QTc interval. Use Caution/Monitor.

• gotu kola

  gotu kola increases effects of hydroxyzine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

• granisetron

  granisetron and hydroxyzine both increase QTc interval. Use Caution/Monitor.

• haloperidol

  hydroxyzine and haloperidol both increase sedation. Use Caution/Monitor.hydroxyzine and haloperidol both increase QTc interval. Use Caution/Monitor.

• hawthorn

  hawthorn increases effects of hydroxyzine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

• histrelin

  hydroxyzine and histrelin both increase QTc interval. Use Caution/Monitor.

• hops

  hops increases effects of hydroxyzine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

• hyaluronidase

  hydroxyzine decreases effects of hyaluronidase by Other (see comment). Use Caution/Monitor. Comment: Antihistamines, when given in large systemic doses, may render tissues partially resistant to the action of hyaluronidase. Patients may require larger amounts of hyaluronidase for equivalent dispersing effect.

• hydromorphone

  hydroxyzine and hydromorphone both increase sedation. Use Caution/Monitor.

• iloperidone

  hydroxyzine and iloperidone both increase sedation. Use Caution/Monitor.

• imipramine

  hydroxyzine and imipramine both increase sedation. Use Caution/Monitor.hydroxyzine and imipramine both increase QTc interval. Use Caution/Monitor.

• inotuzumab

  hydroxyzine and inotuzumab both increase QTc interval. Modify Therapy/Monitor Closely. If coadministration necessary, obtain baseline ECG to assess initial QT interval and determine frequency of subsequent monitoring; avoid non-essential QT prolonging drug and correct electrolyte imbalances

• isoproterenol

  hydroxyzine increases and isoproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• itraconazole

  hydroxyzine and itraconazole both increase QTc interval. Use Caution/Monitor.itraconazole and hydroxyzine both increase QTc interval. Use Caution/Monitor.

• ivosidenib

  hydroxyzine and ivosidenib both decrease QTc interval. Modify Therapy/Monitor Closely. If coadministration necessary, obtain baseline ECG to assess initial QT interval and determine frequency of subsequent monitoring; avoid non-essential QT prolonging drug and correct electrolyte imbalances

• kava

  kava increases effects of hydroxyzine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

• ketamine

  ketamine and hydroxyzine both increase sedation. Use Caution/Monitor.

• ketotifen, ophthalmic

  hydroxyzine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

• lapatinib

  hydroxyzine and lapatinib both increase QTc interval. Use Caution/Monitor.

• lasmiditan

  lasmiditan, hydroxyzine. Either increases effects of the other by sedation. Use Caution/Monitor. Coadministration of lasmiditan and other CNS depressant drugs, including alcohol have not been evaluated in clinical studies. Lasmiditan may cause sedation, as well as other cognitive and/or neuropsychiatric adverse reactions.

• lemborexant

  lemborexant, hydroxyzine. Either increases effects of the other by sedation. Modify Therapy/Monitor Closely. Dosage adjustment may be necessary if lemborexant is coadministered with other CNS depressants because of potentially additive effects.

• leuprolide

  hydroxyzine and leuprolide both increase QTc interval. Use Caution/Monitor.

• levalbuterol

  hydroxyzine increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• levofloxacin

  hydroxyzine and levofloxacin both increase QTc interval. Use Caution/Monitor.

• levorphanol

  hydroxyzine and levorphanol both increase sedation. Use Caution/Monitor.

• lisdexamfetamine

  hydroxyzine increases and lisdexamfetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• lithium

  hydroxyzine and lithium both increase QTc interval. Use Caution/Monitor.

• lofepramine

  hydroxyzine and lofepramine both increase sedation. Use Caution/Monitor.

• lofexidine

  hydroxyzine and lofexidine both increase sedation. Use Caution/Monitor.

• loperamide

  hydroxyzine and loperamide both increase QTc interval. Use Caution/Monitor.

• loprazolam

  hydroxyzine and loprazolam both increase sedation. Use Caution/Monitor.

• lorazepam

  hydroxyzine and lorazepam both increase sedation. Use Caution/Monitor.

• lormetazepam

  hydroxyzine and lormetazepam both increase sedation. Use Caution/Monitor.

• loxapine

  hydroxyzine and loxapine both increase sedation. Use Caution/Monitor.

• loxapine inhaled

  hydroxyzine and loxapine inhaled both increase sedation. Use Caution/Monitor.

• lurasidone

  lurasidone, hydroxyzine. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: Potential for increased CNS depressant effects when used concurrently; monitor for increased adverse effects and toxicity.

• maprotiline

  hydroxyzine and maprotiline both increase sedation. Use Caution/Monitor.hydroxyzine and maprotiline both increase QTc interval. Use Caution/Monitor.

• marijuana

  hydroxyzine and marijuana both increase sedation. Use Caution/Monitor.

• mefloquine

  hydroxyzine and mefloquine both increase QTc interval. Use Caution/Monitor.

• melatonin

  hydroxyzine and melatonin both increase sedation. Use Caution/Monitor.

• meperidine

  hydroxyzine and meperidine both increase sedation. Use Caution/Monitor.

• meprobamate

  hydroxyzine and meprobamate both increase sedation. Use Caution/Monitor.

• metaproterenol

  hydroxyzine increases and metaproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• metaxalone

  hydroxyzine and metaxalone both increase sedation. Use Caution/Monitor.

• methadone

  hydroxyzine and methadone both increase sedation. Use Caution/Monitor.hydroxyzine increases toxicity of methadone by QTc interval. Use Caution/Monitor. Increases risk of torsades de pointes.

• methamphetamine

  hydroxyzine increases and methamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• methocarbamol

  hydroxyzine and methocarbamol both increase sedation. Use Caution/Monitor.

• methylenedioxymethamphetamine

  hydroxyzine increases and methylenedioxymethamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• midazolam

  hydroxyzine and midazolam both increase sedation. Use Caution/Monitor.

• midazolam intranasal

  midazolam intranasal, hydroxyzine. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Concomitant use of barbiturates, alcohol, or other CNS depressants may increase the risk of hypoventilation, airway obstruction, desaturation, or apnea and may contribute to profound and/or prolonged drug effect.

• midodrine

  hydroxyzine increases and midodrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• mirtazapine

  hydroxyzine and mirtazapine both increase sedation. Use Caution/Monitor.hydroxyzine and mirtazapine both increase QTc interval. Use Caution/Monitor.

• modafinil

  hydroxyzine increases and modafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• morphine

  hydroxyzine and morphine both increase sedation. Use Caution/Monitor.

• motherwort

  hydroxyzine and motherwort both increase sedation. Use Caution/Monitor.

• moxifloxacin

  hydroxyzine increases toxicity of moxifloxacin by QTc interval. Use Caution/Monitor. Increases risk of torsades de pointes.

• moxonidine

  hydroxyzine and moxonidine both increase sedation. Use Caution/Monitor.

• nabilone

  hydroxyzine and nabilone both increase sedation. Use Caution/Monitor.

• nalbuphine

  hydroxyzine and nalbuphine both increase sedation. Use Caution/Monitor.

• norepinephrine

  hydroxyzine increases and norepinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• nortriptyline

  hydroxyzine and nortriptyline both increase sedation. Use Caution/Monitor.hydroxyzine and nortriptyline both increase QTc interval. Use Caution/Monitor.

• octreotide

  hydroxyzine and octreotide both increase QTc interval. Use Caution/Monitor.

• ofloxacin

  hydroxyzine and ofloxacin both increase QTc interval. Use Caution/Monitor.

• olanzapine

  hydroxyzine and olanzapine both increase sedation. Use Caution/Monitor.hydroxyzine and olanzapine both increase QTc interval. Use Caution/Monitor. Limited data, including some case reports, suggest that olanzapine may be associated with a significant prolongation of the QTc interval in rare instances

• ondansetron

  hydroxyzine increases toxicity of ondansetron by QTc interval. Use Caution/Monitor. Increases risk of torsades de pointes.

• opium tincture

  hydroxyzine and opium tincture both increase sedation. Use Caution/Monitor.

• orphenadrine

  hydroxyzine and orphenadrine both increase sedation. Use Caution/Monitor.

• osilodrostat

  osilodrostat and hydroxyzine both increase QTc interval. Use Caution/Monitor.

• oxazepam

  hydroxyzine and oxazepam both increase sedation. Use Caution/Monitor.

• oxycodone

  hydroxyzine and oxycodone both increase sedation. Use Caution/Monitor.

• oxymorphone

  hydroxyzine and oxymorphone both increase sedation. Use Caution/Monitor.

• paliperidone

  hydroxyzine and paliperidone both increase sedation. Use Caution/Monitor.

• papaveretum

  hydroxyzine and papaveretum both increase sedation. Use Caution/Monitor.

• papaverine

  hydroxyzine and papaverine both increase sedation. Use Caution/Monitor.

• paroxetine

  hydroxyzine and paroxetine both increase QTc interval. Use Caution/Monitor.

• pasireotide

  hydroxyzine and pasireotide both increase QTc interval. Use Caution/Monitor.

• passion flower

  passion flower increases effects of hydroxyzine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

• pentamidine

  hydroxyzine increases toxicity of pentamidine by QTc interval. Use Caution/Monitor. Increases risk of torsades de pointes.

• pentazocine

  hydroxyzine and pentazocine both increase sedation. Use Caution/Monitor.

• pentobarbital

  hydroxyzine and pentobarbital both increase sedation. Use Caution/Monitor.

• perampanel

  perampanel and hydroxyzine both increase sedation. Use Caution/Monitor.

• perphenazine

  hydroxyzine and perphenazine both increase sedation. Use Caution/Monitor.hydroxyzine and perphenazine both increase QTc interval. Use Caution/Monitor.

• phendimetrazine

  hydroxyzine increases and phendimetrazine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• phenelzine

  phenelzine increases effects of hydroxyzine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Coadministration of phenelzine and antihistamines may result in additive CNS depressant effects. MAO inhibitors also prolong and intensify anticholinergic effects of antihistamines. .

• phenobarbital

  hydroxyzine and phenobarbital both increase sedation. Use Caution/Monitor.

• phentermine

  hydroxyzine increases and phentermine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• phenylephrine

  hydroxyzine increases and phenylephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• phenylephrine PO

  hydroxyzine increases and phenylephrine PO decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. .

• pholcodine

  hydroxyzine and pholcodine both increase sedation. Use Caution/Monitor.

• pimozide

  hydroxyzine and pimozide both increase sedation. Use Caution/Monitor.

• pirbuterol

  hydroxyzine increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• posaconazole

  hydroxyzine and posaconazole both increase QTc interval. Use Caution/Monitor.

• pregabalin

  pregabalin, hydroxyzine. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.

• primaquine

  hydroxyzine and primaquine both increase QTc interval. Use Caution/Monitor.

• primidone

  hydroxyzine and primidone both increase sedation. Use Caution/Monitor.

• prochlorperazine

  hydroxyzine and prochlorperazine both increase sedation. Use Caution/Monitor.hydroxyzine and prochlorperazine both decrease QTc interval. Use Caution/Monitor.

• promethazine

  hydroxyzine and promethazine both increase sedation. Use Caution/Monitor.hydroxyzine and promethazine both decrease QTc interval. Use Caution/Monitor.

• propofol

  propofol and hydroxyzine both increase sedation. Use Caution/Monitor.

• propylhexedrine

  hydroxyzine increases and propylhexedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• protriptyline

  hydroxyzine and protriptyline both increase sedation. Use Caution/Monitor.hydroxyzine and protriptyline both increase QTc interval. Use Caution/Monitor.

• quazepam

  hydroxyzine and quazepam both increase sedation. Use Caution/Monitor.

• quetiapine

  hydroxyzine and quetiapine both increase sedation. Use Caution/Monitor.

• ramelteon

  hydroxyzine and ramelteon both increase sedation. Use Caution/Monitor.

• ranolazine

  hydroxyzine and ranolazine both increase QTc interval. Use Caution/Monitor.

• rilpivirine

  hydroxyzine and rilpivirine both increase QTc interval. Use Caution/Monitor.

• risperidone

  hydroxyzine and risperidone both increase sedation. Use Caution/Monitor.hydroxyzine and risperidone both increase QTc interval. Use Caution/Monitor.

• romidepsin

  hydroxyzine and romidepsin both increase QTc interval. Use Caution/Monitor.

• salmeterol

  hydroxyzine increases and salmeterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• scullcap

  hydroxyzine and scullcap both increase sedation. Use Caution/Monitor.

• secobarbital

  hydroxyzine and secobarbital both increase sedation. Use Caution/Monitor.

• sertraline

  hydroxyzine and sertraline both increase QTc interval. Use Caution/Monitor.

• sevoflurane

  sevoflurane and hydroxyzine both increase sedation. Use Caution/Monitor.

• shepherd's purse

  hydroxyzine and shepherd's purse both increase sedation. Use Caution/Monitor.

• solifenacin

  hydroxyzine and solifenacin both increase QTc interval. Use Caution/Monitor.

• stiripentol

  stiripentol, hydroxyzine. Either increases effects of the other by sedation. Use Caution/Monitor. Concomitant use stiripentol with other CNS depressants, including alcohol, may increase the risk of sedation and somnolence.

• sufentanil

  hydroxyzine and sufentanil both increase sedation. Use Caution/Monitor.

• sunitinib

  hydroxyzine and sunitinib both increase QTc interval. Use Caution/Monitor.

• tacrolimus

  hydroxyzine and tacrolimus both increase QTc interval. Use Caution/Monitor.

• tapentadol

  hydroxyzine and tapentadol both increase sedation. Use Caution/Monitor.

• telavancin

  hydroxyzine and telavancin both increase QTc interval. Use Caution/Monitor.

• temazepam

  hydroxyzine and temazepam both increase sedation. Use Caution/Monitor.

• terbutaline

  hydroxyzine increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• thioridazine

  hydroxyzine and thioridazine both increase sedation. Use Caution/Monitor.

• thiothixene

  hydroxyzine and thiothixene both increase sedation. Use Caution/Monitor.

• topiramate

  hydroxyzine and topiramate both increase sedation. Modify Therapy/Monitor Closely.

• tramadol

  hydroxyzine and tramadol both increase sedation. Use Caution/Monitor.

• trazodone

  hydroxyzine and trazodone both increase sedation. Use Caution/Monitor.

• triazolam

  hydroxyzine and triazolam both increase sedation. Use Caution/Monitor.

• triclabendazole

  hydroxyzine and triclabendazole both increase QTc interval. Use Caution/Monitor.

• triclofos

  hydroxyzine and triclofos both increase sedation. Use Caution/Monitor.

• trifluoperazine

  hydroxyzine and trifluoperazine both increase sedation. Use Caution/Monitor.hydroxyzine and trifluoperazine both decrease QTc interval. Use Caution/Monitor.

• trimipramine

  hydroxyzine and trimipramine both increase sedation. Use Caution/Monitor.hydroxyzine and trimipramine both increase QTc interval. Use Caution/Monitor.

• triprolidine

  hydroxyzine and triprolidine both increase sedation. Use Caution/Monitor.

• triptorelin

  hydroxyzine and triptorelin both increase QTc interval. Use Caution/Monitor.

• valerian

  valerian increases effects of hydroxyzine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

• vardenafil

  hydroxyzine and vardenafil both increase QTc interval. Use Caution/Monitor.

• venlafaxine

  hydroxyzine and venlafaxine both decrease QTc interval. Use Caution/Monitor.

• voclosporin

  hydroxyzine and voclosporin both increase QTc interval. Use Caution/Monitor.

• vorinostat

  hydroxyzine and vorinostat both increase QTc interval. Use Caution/Monitor.

• xylometazoline

  hydroxyzine increases and xylometazoline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• yohimbine

  hydroxyzine increases and yohimbine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• ziconotide

  hydroxyzine and ziconotide both increase sedation. Use Caution/Monitor.

• ziprasidone

  hydroxyzine and ziprasidone both increase sedation. Use Caution/Monitor.

• zotepine

  hydroxyzine and zotepine both increase sedation. Use Caution/Monitor.

Minor (6)

• ashwagandha

  ashwagandha increases effects of hydroxyzine by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.

• brimonidine

  brimonidine increases effects of hydroxyzine by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

• eucalyptus

  hydroxyzine and eucalyptus both increase sedation. Minor/Significance Unknown.

• nettle

  nettle increases effects of hydroxyzine by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.

• sage

  hydroxyzine and sage both increase sedation. Minor/Significance Unknown.

• Siberian ginseng

  Siberian ginseng increases effects of hydroxyzine by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.

• albuterol

  Monitor Closely (2)hydroxyzine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  albuterol and hydroxyzine both increase QTc interval. Use Caution/Monitor.